Exosomes isolation and characterization in serum is feasible in non-small cell lung cancer patients: critical analysis of evidence and potential role in clinical practice

Marco Giallombardo, Riccardo Alessandro, Simona Taverna, Marta Castiglia, Antonio Araujo, Ignacio Gil-Bazo, Marc Peeters, Simona Taverna, Marta Castiglia, Marco Giallombardo, Patrick Pauwels, Jorge Chacártegui, Anna Paola Carreca, Christian Rolfo, Riccardo Alessandro, Christian Diego Rolfo

Risultato della ricerca: Articlepeer review

59 Citazioni (Scopus)

Abstract

Exosomes are nano-sized vesicles of endolysosomal origin, released by several cytotypes in physiological and pathological conditions. Tumor derived exosomes, interacting with other cells of the tumor microenvironment, modulate tumor progression, angiogenic switch, metastasis, and immune escape. Recently, extracellular vesicles were proposed as excellent biomarkers for disease monitoring and prognosis in cancer patients. Non-small cell lung cancer (NSCLC) has a poor 5-year survival rate due to the delay in the detection of the disease. The majority of patients are diagnosed in an advanced disease stage. Exosomes might be promising beneficial tools as biomarker candidates in the scenario of NSCLC, since they contain both, proteins and miRNAs. The clinical case reported in this manuscript is a proof of concept revealing that NSCLC exosomes and sorted miRNAs might constitute, in a near future, novel biomarkers. This review summarizes the role of exosomes in NSCLC, focusing on the importance of exosomal microRNAs in lung cancer diagnosis and prognosis
Lingua originaleEnglish
pagine (da-a)28748-28760
Numero di pagine13
RivistaOncotarget
Volume7
Stato di pubblicazionePublished - 2016

All Science Journal Classification (ASJC) codes

  • Oncology

Fingerprint Entra nei temi di ricerca di 'Exosomes isolation and characterization in serum is feasible in non-small cell lung cancer patients: critical analysis of evidence and potential role in clinical practice'. Insieme formano una fingerprint unica.

Cita questo