Exosomes as Intercellular Signaling Organelles Involved inHealth and Disease: Basic Science and Clinical Applications

Risultato della ricerca: Article

170 Citazioni (Scopus)

Abstract

Cell to cell communication is essential for the coordination and properorganization of different cell types in multicellular systems. Cells exchange informationthrough a multitude of mechanisms such as secreted growth factors and chemokines, smallmolecules (peptides, ions, bioactive lipids and nucleotides), cell-cell contact and thesecretion of extracellular matrix components. Over the last few years, however, aconsiderable amount of experimental evidence has demonstrated the occurrence of asophisticated method of cell communication based on the release of specializedmembranous nano-sized vesicles termed exosomes. Exosome biogenesis involves theendosomal compartment, the multivesicular bodies (MVB), which contain internal vesiclespacked with an extraordinary set of molecules including enzymes, cytokines, nucleic acidsand different bioactive compounds. In response to stimuli, MVB fuse with the plasmamembrane and vesicles are released in the extracellular space where they can interact withneighboring cells and directly induce a signaling pathway or affect the cellular phenotypethrough the transfer of new receptors or even genetic material. This review will focus on exosomes as intercellular signaling organelles involved in a number of physiological aswell as pathological processes and their potential use in clinical diagnostics and therapeutics.
Lingua originaleEnglish
Numero di pagine0
RivistaInternational Journal of Molecular Sciences
Volume14
Stato di pubblicazionePublished - 2013

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cita questo