Exosome levels in human body fluids: A tumor marker by themselves?

Claudia Campanella, Celeste Caruso Bavisotto, Francesco Cappello, Claudia Campanella, Celeste Caruso Bavisotto, Francesca Properzi, Mariantonia Logozzi, Stefano Fais, Antonio Marcilla, Francesco Cappello

Risultato della ricerca: Article

73 Citazioni (Scopus)

Abstract

Despite considerable research efforts, the finding of reliable tumor biomarkers remains challenging and unresolved. In recent years a novel diagnostic biomedical tool with high potential has been identified in extracellular nanovesicles or exosomes. They are released by the majority of the cells and contain detailed molecular information on the cell of origin including tumor hallmarks. Exosomes can be isolated from easy accessible body fluids, and most importantly, they can provide several biomarkers, with different levels of specificity. Recent clinical evidence shows that the levels of exosomes released into body fluids may themselves represent a predictive/diagnostic of tumors, discriminating cancer patients from healthy subjects. The aim of this review is to highlight these latest challenging findings to provide novel and groundbreaking ideas for successful tumor early diagnosis and follow-up.
Lingua originaleEnglish
pagine (da-a)93-98
Numero di pagine6
RivistaEuropean Journal of Pharmaceutical Sciences
Volume96
Stato di pubblicazionePublished - 2017

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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    Campanella, C., Caruso Bavisotto, C., Cappello, F., Campanella, C., Bavisotto, C. C., Properzi, F., Logozzi, M., Fais, S., Marcilla, A., & Cappello, F. (2017). Exosome levels in human body fluids: A tumor marker by themselves? European Journal of Pharmaceutical Sciences, 96, 93-98.