Exosome A Clinical Compendium - Chapter 1: Exosome basic mechanisms

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Abstract

Cell-cell communication plays a key role in maintaining homeostasis in multicellular organism. Cells communicate each other not only via the canonical pathways (cytokines, neurotransmitters, direct contact, ECM-mediated interactions or hormones) but also releasing extracellular vesicles that can reach different regions of the organism acting as a new “endocrine signalling mechanism”. Among extracellular vesicles, exosomes are emerging as efficient players to modulate target cells phenotype through the delivery to compliant receiving cells of a multitude of molecules such as mRNAs, microRNAs, long non-coding RNAs, DNA, lipids, metabolites and proteins. A deeper understanding of their contents as well as of their mechanism of action is therefore needed to get the most from this incredible “cell treasure”.
Lingua originaleEnglish
Titolo della pubblicazione ospiteExosome - A clinical Compendium
Pagine1-21
Numero di pagine21
Stato di pubblicazionePublished - 2019

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Exosomes
Long Noncoding RNA
MicroRNAs
Cell Communication
Neurotransmitter Agents
Homeostasis
Hormones
Cytokines
Phenotype
Lipids
Messenger RNA
DNA
Proteins

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abstract = "Cell-cell communication plays a key role in maintaining homeostasis in multicellular organism. Cells communicate each other not only via the canonical pathways (cytokines, neurotransmitters, direct contact, ECM-mediated interactions or hormones) but also releasing extracellular vesicles that can reach different regions of the organism acting as a new “endocrine signalling mechanism”. Among extracellular vesicles, exosomes are emerging as efficient players to modulate target cells phenotype through the delivery to compliant receiving cells of a multitude of molecules such as mRNAs, microRNAs, long non-coding RNAs, DNA, lipids, metabolites and proteins. A deeper understanding of their contents as well as of their mechanism of action is therefore needed to get the most from this incredible “cell treasure”.",
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