Exosomal HSP60: a potentially useful biomarker for diagnosis, assessing prognosis, and monitoring response to treatment

Francesco Cappello, Claudia Campanella, Celeste Caruso Bavisotto, Celeste Caruso Bavisotto, Mariantonia Logozzi, Stefano Fais, Francesco Cappello, Everly Conway De Macario, Alberto J.L. Macario

Risultato della ricerca: Article

33 Citazioni (Scopus)

Abstract

Introduction: Cell-to-cell communication is imperative for life and it is mediated by sending and receiving information via the secretion and subsequent receptor-mediated detection of biological molecules. Exosomes (EXs) secreted from cells to the extracellular environment play an important role in intercellular communication in normal and pathological conditions. Areas covered: New evidence indicates that tumor cells-derived EXs contribute to cancer progression through the modulation of tumor microenvironment. The exosomal heat shock protein 60 (HSP60) is very likely a key player in intercellular cross-talk, particularly during the progress of diseases, such as cancer. Many studies have focused on the extracellular roles played by HSP60 that pertain to cancer development and immune system stimulation. Our experimental data in vitro and in vivo demonstrated that HSP60 occurs on the surface of EXs secreted by tumour cells. Expert commentary: Exosomal HSP60 has great potential for clinical applications, as a âliquid biopsyâ, including its use as biomarker for diagnostics, assessing prognosis, and monitoring disease progression and response to treatment, particularly in cancer.
Lingua originaleEnglish
pagine (da-a)815-822
Numero di pagine8
RivistaExpert Review of Molecular Diagnostics
Volume17
Stato di pubblicazionePublished - 2017

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Molecular Medicine
  • Molecular Biology
  • Genetics

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