Exosomal Chaperones and miRNAs in Gliomagenesis: State-of-Art and Theranostics Perspectives

Antonella Marino Gammazza, Francesca Graziano, Fabio Bucchieri, Francesco Cappello, Celeste Caruso Bavisotto, Claudia Campanella, Francesca Rappa, Claudia Campanella, Antonella Marino Gammazza, Francesca Rappa, Celeste Caruso Bavisotto, Mariantonia Logozzi, Everly Conway De Macario, Stefano Fais, Francesco Cappello, Alberto J. L. Macario

Risultato della ricerca: Article

11 Citazioni (Scopus)

Abstract

Gliomas have poor prognosis no matter the treatment applied, remaining an unmet clinical need. As background for a substantial change in this situation, this review will focus on the following points: (i) the steady progress in establishing the role of molecular chaperones in carcinogenesis; (ii) the recent advances in the knowledge of miRNAs in regulating gene expression, including genes involved in carcinogenesis and genes encoding chaperones; and (iii) the findings about exosomes and their cargo released by tumor cells. We would like to trigger a discussion about the involvement of exosomal chaperones and miRNAs in gliomagenesis. Chaperones may be either targets for therapy, due to their tumor-promoting activity, or therapeutic agents, due to their antitumor growth activity. Thus, chaperones may well represent a Janus-faced approach against tumors. This review focuses on extracellular chaperones as part of exosomes’ cargo, because of their potential as a new tool for the diagnosis and management of gliomas. Moreover, since exosomes transport chaperones and miRNAs (the latter possibly related to chaperone gene expression in the recipient cell), and probably deliver their cargo in the recipient cells, a new area of investigation is now open, which is bound to generate significant advances in the understanding and treatment of gliomas.
Lingua originaleEnglish
Numero di pagine20
RivistaInternational Journal of Molecular Sciences
Stato di pubblicazionePublished - 2018

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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