Exhaled nitric oxide (eNO) levels are correlated with several markers of atopy and inflammatory activity in the airways, but the relationshipbetween eNO and total serum IgE has not been fully elucidated in the context of allergic sensitization. The aim of this study was toinvestigate the relationship between eNO, total serum IgE and allergic sensitization in childhood asthma and allergic rhinitis. eNO levels, lungfunction, skin prick tests and total serum IgE were determined in 109 children (mean age, 10.4 yr) with mild intermittent asthma and in41 children (mean age, 10.1 yr) with allergic rhinitis; 25 healthy nonatopic children were recruited as controls. eNO levels (median) weresignificantly higher in patients with asthma (22.7 p.p.b.) and in those with allergic rhinitis (15.3 p.p.b.) than in healthy controls (5.9 p.p.b.). Children with allergic asthma had higher eNO levels than children with allergic rhinitis. A significant positive correlation was found between eNO and total serum IgE (asthma, r = 0.42, p < 0.0001; allergic rhinitis, r = 0.31, p < 0.01), and between eNO and the number of positive skin prick tests (asthma, r = 0.31, p < 0.0001; allergic rhinitis, r = 0.39, p < 0.01). eNO levels were better correlated with total IgE than with the number of positive skin prick tests. This correlation was independentof allergic sensitization. High total serum IgE represents a specific and predictive marker of eNO increase in children with asthma or allergic rhinitis. This finding adds further support to the hypothesis that increased serum IgE could be a marker itself of airway inflammationin patients with allergic disease.
|Rivista||Pediatric Allergy and Immunology|
|Stato di pubblicazione||Published - 2005|
All Science Journal Classification (ASJC) codes
- Pediatrics, Perinatology, and Child Health
- Immunology and Allergy