TY - JOUR
T1 - Exercise for depression in older adults: A meta-analysis of randomized controlled trials adjusting for publication bias
AU - Veronese, Nicola
AU - Schuch, Felipe B.
AU - Cadore, Eduardo L.
AU - Vancampfort, Davy
AU - Veronese, Nicola
AU - Rosenbaum, Simon
AU - Richards, Justin
AU - Stubbs, Brendon
AU - Solmi, Marco
AU - Ward, Philip B.
PY - 2016
Y1 - 2016
N2 - Objective: To evaluate the antidepressant effects of exercise in older adults, using randomized controlled trial (RCT) data. Methods: We conducted a meta-analysis of exercise in older adults, addressing limitations of previous works. RCTs of exercise interventions in older people with depression (≥ 60 years) comparing exercise vs. control were eligible. A random-effects meta-analysis calculating the standardized mean difference (SMD) (95% confidence interval [95%CI]), meta-regressions, and trim, fill, and fail-safe number analyses were conducted. Results: Eight RCTs were included, representing 138 participants in exercise arms and 129 controls. Exercise had a large and significant effect on depression (SMD =-0.90 [95%CI-0.29 to-1.51]), with a fail-safe number of 71 studies. Significant effects were found for 1) mixed aerobic and anaerobic interventions, 2) at moderate intensity, 3) that were group-based, 4) that utilized mixed supervised and unsupervised formats, and 5) in people without other clinical comorbidities. Conclusion: Adjusting for publication bias increased the beneficial effects of exercise in three subgroup analysis, suggesting that previous meta-analyses have underestimated the benefits of exercise due to publication bias. We advocate that exercise be considered as a routine component of the management of depression in older adults. © 2016, Associacao Brasileira de Psiquiatria. All rights reserved.
AB - Objective: To evaluate the antidepressant effects of exercise in older adults, using randomized controlled trial (RCT) data. Methods: We conducted a meta-analysis of exercise in older adults, addressing limitations of previous works. RCTs of exercise interventions in older people with depression (≥ 60 years) comparing exercise vs. control were eligible. A random-effects meta-analysis calculating the standardized mean difference (SMD) (95% confidence interval [95%CI]), meta-regressions, and trim, fill, and fail-safe number analyses were conducted. Results: Eight RCTs were included, representing 138 participants in exercise arms and 129 controls. Exercise had a large and significant effect on depression (SMD =-0.90 [95%CI-0.29 to-1.51]), with a fail-safe number of 71 studies. Significant effects were found for 1) mixed aerobic and anaerobic interventions, 2) at moderate intensity, 3) that were group-based, 4) that utilized mixed supervised and unsupervised formats, and 5) in people without other clinical comorbidities. Conclusion: Adjusting for publication bias increased the beneficial effects of exercise in three subgroup analysis, suggesting that previous meta-analyses have underestimated the benefits of exercise due to publication bias. We advocate that exercise be considered as a routine component of the management of depression in older adults. © 2016, Associacao Brasileira de Psiquiatria. All rights reserved.
UR - http://hdl.handle.net/10447/455231
UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-84984597005&doi=10.1590/1516-4446-2016-1915&partnerID=40&md5=de3ec4be1599ba0c9355e221babfca62
M3 - Article
VL - 38
SP - 247
EP - 254
JO - Revista Brasileira de Psiquiatria
JF - Revista Brasileira de Psiquiatria
SN - 1516-4446
ER -