Exercise and conjugated linoleic acid supplementation induce changes in the composition of liver fatty acids

Valentina Di Felice, Rosario Barone, Filippo Macaluso, Adriana Mika, Rosario Barone, Aleksandra Czumaj, Piotr Stepnowski, Tomasz Sledzinski, Valentina Di Felice

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Exercise and supplementation with conjugated linoleic acid (CLA) are used to reducebody weight and to improve health. Applied together, they may exert a synergisticeffect. However, the effects of exercise and CLA supplementation on liver metabolismare poorly understood. The aim of this study was to examine the influence of exerciseand CLA supplementation on fatty acids (FA) composition in mouse liver. We analyzed44 of known FAs of this organ by gas chromatography-mass spectrometry. Our resultsdemonstrated that exercise contributed to a decrease in odd-chain FA and an increasein n-6 polyunsaturated FA contents. In turn, CLA stimulated an increase in branchedchainFAs and n-3 polyunsaturated FAs. Exercise combined with CLA supplementationcaused a substantial increase in branched-chain FA content and a slight increase in n-6polyunsaturated FAs. The elevated liver content of branched-chain FAs after the exercisecombined with CLA supplementation, as well as the increase in n-3 polyunsaturatedFAs after CLA may be favorable since both these FA groups were previously shown toproduce health benefits. However, the expression pattern of enzymes involved in fattyacid synthesis did not match the changes in FA composition. Thus, the mechanism ofexercise- and CLA-induced changes in liver FA profile is yet to be established. Also, theconsequences of CLA- and/or exercise-induced changes in the composition of liver FAsneed to be elucidated.
Lingua originaleEnglish
Numero di pagine7
RivistaFrontiers in Physiology
Stato di pubblicazionePublished - 2019

All Science Journal Classification (ASJC) codes

  • ???subjectarea.asjc.1300.1314???
  • ???subjectarea.asjc.2700.2737???


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