Abstract
| Lingua originale | English |
|---|---|
| pagine (da-a) | 1999-2006 |
| Numero di pagine | 8 |
| Rivista | Journal of Medical Virology |
| Volume | 81 |
| Stato di pubblicazione | Published - 2009 |
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All Science Journal Classification (ASJC) codes
- Virology
- Infectious Diseases
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Evolving clinical landscape of chronic hepatitis B: A multicenter Italian study. / Almasio, Pier Luigi; Iacomi, Fabio; Stanzione, Maria; Stornaiuolo, Gianfranca; Roffi, Luigi; Babudieri, Sergio; Morisco, Filomena; Pintus, Antonio; Giuberti, Tiziana; Pinzello, Giovanbattista; Ciancio, Alessia; Ferrigno, Luigina; Fagiuoli, Stefano; Mangano, Carmelo; Messina, Vincenzo; Sagnelli, Evangelista; Piccinino, Felice; Fattovich, Giovanna; Chiaramonte, Maria; Smedile, Antonina; Massari, Marco; Antonucci, Giorgio; Caporaso, Nicola; Pastore, Giuseppe; Mele, Alfonso; Caccamo, Gaia; Caserta, Carmelo; Palattella, Stefania; Magnani, Giacomo; Andreone, Pietro; Scuteri, Alessandra; Olivari, Nicola; Bellia, Valentina; Rizzetto, Mario; Brunetto, Maurizia; Sasso, Rodolfo; Gaeta, Giovanni Battista; Lattanzi, Emiliano; Vinci, Maria; Stroffolini, Tommaso; Ferrari, Carlo; Boninsegna, Sara; Raimondo, Giovanni; Brancaccio, Giuseppina.
In: Journal of Medical Virology, Vol. 81, 2009, pag. 1999-2006.Risultato della ricerca: Article
}
TY - JOUR
T1 - Evolving clinical landscape of chronic hepatitis B: A multicenter Italian study.
AU - Almasio, Pier Luigi
AU - Iacomi, Fabio
AU - Stanzione, Maria
AU - Stornaiuolo, Gianfranca
AU - Roffi, Luigi
AU - Babudieri, Sergio
AU - Morisco, Filomena
AU - Pintus, Antonio
AU - Giuberti, Tiziana
AU - Pinzello, Giovanbattista
AU - Ciancio, Alessia
AU - Ferrigno, Luigina
AU - Fagiuoli, Stefano
AU - Mangano, Carmelo
AU - Messina, Vincenzo
AU - Sagnelli, Evangelista
AU - Piccinino, Felice
AU - Fattovich, Giovanna
AU - Chiaramonte, Maria
AU - Smedile, Antonina
AU - Massari, Marco
AU - Antonucci, Giorgio
AU - Caporaso, Nicola
AU - Pastore, Giuseppe
AU - Mele, Alfonso
AU - Caccamo, Gaia
AU - Caserta, Carmelo
AU - Palattella, Stefania
AU - Magnani, Giacomo
AU - Andreone, Pietro
AU - Scuteri, Alessandra
AU - Olivari, Nicola
AU - Bellia, Valentina
AU - Rizzetto, Mario
AU - Brunetto, Maurizia
AU - Sasso, Rodolfo
AU - Gaeta, Giovanni Battista
AU - Lattanzi, Emiliano
AU - Vinci, Maria
AU - Stroffolini, Tommaso
AU - Ferrari, Carlo
AU - Boninsegna, Sara
AU - Raimondo, Giovanni
AU - Brancaccio, Giuseppina
PY - 2009
Y1 - 2009
N2 - The aim of the study was to evaluate the characteristics of chronic hepatitis B with special reference to the geographical origin of the patients and to the prevalence of HBeAg and viral and non-viral co-factors of liver disease. A cross-sectional multicenter survey was undertaken, which enrolled 1,386 HBsAg chronic carriers observed consecutively in 21 referral centers over a 6-month period. The prevalence of HBeAg in patients was 11%; the presence of HBeAg was associated independently with a younger age and co-infection with HIV. Anti-HDV, anti-HCV, or anti-HIV antibodies were detected in 8.1%, 6.5%, and 2%, respectively. However, among the patients first diagnosed during the study period (incident cases), 14.3% were anti-HDV positive. Seven percent of the patients were immigrants; they were younger than Italian patients and 18% were HBeAg positive; no difference was observed in the prevalence of anti-HDV, anti-HCV, or anti-HIV antibodies. The presence of cirrhosis was associated independently with an age >52 years, the presence of anti-HDV or anti-HCV, alcohol use >4 drinks/day, and a high BMI. The clinical epidemiology of chronic hepatitis B virus (HBV) infection shows a dynamic profile, with the potential for re-emergence of cases with HBeAg or anti-HDV and an emerging impact of metabolic factors on the evolution of liver disease.
AB - The aim of the study was to evaluate the characteristics of chronic hepatitis B with special reference to the geographical origin of the patients and to the prevalence of HBeAg and viral and non-viral co-factors of liver disease. A cross-sectional multicenter survey was undertaken, which enrolled 1,386 HBsAg chronic carriers observed consecutively in 21 referral centers over a 6-month period. The prevalence of HBeAg in patients was 11%; the presence of HBeAg was associated independently with a younger age and co-infection with HIV. Anti-HDV, anti-HCV, or anti-HIV antibodies were detected in 8.1%, 6.5%, and 2%, respectively. However, among the patients first diagnosed during the study period (incident cases), 14.3% were anti-HDV positive. Seven percent of the patients were immigrants; they were younger than Italian patients and 18% were HBeAg positive; no difference was observed in the prevalence of anti-HDV, anti-HCV, or anti-HIV antibodies. The presence of cirrhosis was associated independently with an age >52 years, the presence of anti-HDV or anti-HCV, alcohol use >4 drinks/day, and a high BMI. The clinical epidemiology of chronic hepatitis B virus (HBV) infection shows a dynamic profile, with the potential for re-emergence of cases with HBeAg or anti-HDV and an emerging impact of metabolic factors on the evolution of liver disease.
KW - HBV, hepatitis, epidemiology
UR - http://hdl.handle.net/10447/44244
M3 - Article
VL - 81
SP - 1999
EP - 2006
JO - Journal of Medical Virology
JF - Journal of Medical Virology
SN - 0146-6615
ER -