Evolving clinical landscape of chronic hepatitis B: A multicenter Italian study.

Pier Luigi Almasio, Carmelo Caserta, Stefania Palattella, Giacomo Magnani, Pietro Andreone, Alessandra Scuteri, Nicola Olivari, Valentina Bellia, Mario Rizzetto, Maurizia Brunetto, Rodolfo Sasso, Giovanni Battista Gaeta, Emiliano Lattanzi, Maria Vinci, Tommaso Stroffolini, Carlo Ferrari, Sara Boninsegna, Giovanni Raimondo, Giuseppina Brancaccio, Alessandra ScuteriFabio Iacomi, Maria Stanzione, Gianfranca Stornaiuolo, Luigi Roffi, Sergio Babudieri, Filomena Morisco, Antonio Pintus, Tiziana Giuberti, Giovanbattista Pinzello, Alessia Ciancio, Luigina Ferrigno, Stefano Fagiuoli, Carmelo Mangano, Vincenzo Messina, Evangelista Sagnelli, Felice Piccinino, Giovanna Fattovich, Maria Chiaramonte, Antonina Smedile, Marco Massari, Giorgio Antonucci, Nicola Caporaso, Giuseppe Pastore, Alfonso Mele, Gaia Caccamo

Risultato della ricerca: Article

53 Citazioni (Scopus)

Abstract

The aim of the study was to evaluate the characteristics of chronic hepatitis B with special reference to the geographical origin of the patients and to the prevalence of HBeAg and viral and non-viral co-factors of liver disease. A cross-sectional multicenter survey was undertaken, which enrolled 1,386 HBsAg chronic carriers observed consecutively in 21 referral centers over a 6-month period. The prevalence of HBeAg in patients was 11%; the presence of HBeAg was associated independently with a younger age and co-infection with HIV. Anti-HDV, anti-HCV, or anti-HIV antibodies were detected in 8.1%, 6.5%, and 2%, respectively. However, among the patients first diagnosed during the study period (incident cases), 14.3% were anti-HDV positive. Seven percent of the patients were immigrants; they were younger than Italian patients and 18% were HBeAg positive; no difference was observed in the prevalence of anti-HDV, anti-HCV, or anti-HIV antibodies. The presence of cirrhosis was associated independently with an age >52 years, the presence of anti-HDV or anti-HCV, alcohol use >4 drinks/day, and a high BMI. The clinical epidemiology of chronic hepatitis B virus (HBV) infection shows a dynamic profile, with the potential for re-emergence of cases with HBeAg or anti-HDV and an emerging impact of metabolic factors on the evolution of liver disease.
Lingua originaleEnglish
pagine (da-a)1999-2006
Numero di pagine8
RivistaJournal of Medical Virology
Volume81
Stato di pubblicazionePublished - 2009

All Science Journal Classification (ASJC) codes

  • Virology
  • Infectious Diseases

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    Almasio, P. L., Caserta, C., Palattella, S., Magnani, G., Andreone, P., Scuteri, A., Olivari, N., Bellia, V., Rizzetto, M., Brunetto, M., Sasso, R., Gaeta, G. B., Lattanzi, E., Vinci, M., Stroffolini, T., Ferrari, C., Boninsegna, S., Raimondo, G., Brancaccio, G., ... Caccamo, G. (2009). Evolving clinical landscape of chronic hepatitis B: A multicenter Italian study. Journal of Medical Virology, 81, 1999-2006.