Evolving clinical landscape of chronic hepatitis B: A multicenter Italian study.

Pier Luigi Almasio, Fabio Iacomi, Maria Stanzione, Gianfranca Stornaiuolo, Luigi Roffi, Sergio Babudieri, Filomena Morisco, Antonio Pintus, Tiziana Giuberti, Giovanbattista Pinzello, Alessia Ciancio, Luigina Ferrigno, Stefano Fagiuoli, Carmelo Mangano, Vincenzo Messina, Evangelista Sagnelli, Felice Piccinino, Giovanna Fattovich, Maria Chiaramonte, Antonina Smedile & 24 others Marco Massari, Giorgio Antonucci, Nicola Caporaso, Giuseppe Pastore, Alfonso Mele, Gaia Caccamo, Carmelo Caserta, Stefania Palattella, Giacomo Magnani, Pietro Andreone, Alessandra Scuteri, Nicola Olivari, Valentina Bellia, Mario Rizzetto, Maurizia Brunetto, Rodolfo Sasso, Giovanni Battista Gaeta, Emiliano Lattanzi, Maria Vinci, Tommaso Stroffolini, Carlo Ferrari, Sara Boninsegna, Giovanni Raimondo, Giuseppina Brancaccio

Risultato della ricerca: Article

51 Citazioni (Scopus)

Abstract

The aim of the study was to evaluate the characteristics of chronic hepatitis B with special reference to the geographical origin of the patients and to the prevalence of HBeAg and viral and non-viral co-factors of liver disease. A cross-sectional multicenter survey was undertaken, which enrolled 1,386 HBsAg chronic carriers observed consecutively in 21 referral centers over a 6-month period. The prevalence of HBeAg in patients was 11%; the presence of HBeAg was associated independently with a younger age and co-infection with HIV. Anti-HDV, anti-HCV, or anti-HIV antibodies were detected in 8.1%, 6.5%, and 2%, respectively. However, among the patients first diagnosed during the study period (incident cases), 14.3% were anti-HDV positive. Seven percent of the patients were immigrants; they were younger than Italian patients and 18% were HBeAg positive; no difference was observed in the prevalence of anti-HDV, anti-HCV, or anti-HIV antibodies. The presence of cirrhosis was associated independently with an age >52 years, the presence of anti-HDV or anti-HCV, alcohol use >4 drinks/day, and a high BMI. The clinical epidemiology of chronic hepatitis B virus (HBV) infection shows a dynamic profile, with the potential for re-emergence of cases with HBeAg or anti-HDV and an emerging impact of metabolic factors on the evolution of liver disease.
Lingua originaleEnglish
pagine (da-a)1999-2006
Numero di pagine8
RivistaJournal of Medical Virology
Volume81
Stato di pubblicazionePublished - 2009

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Hepatitis B e Antigens
Chronic Hepatitis B
Multicenter Studies
HIV Antibodies
Liver Diseases
Anti-Idiotypic Antibodies
Virus Diseases
Hepatitis B Surface Antigens
Coinfection
Hepatitis B virus
Epidemiology
Fibrosis
Referral and Consultation
Cross-Sectional Studies
Alcohols
HIV

All Science Journal Classification (ASJC) codes

  • Virology
  • Infectious Diseases

Cita questo

Almasio, P. L., Iacomi, F., Stanzione, M., Stornaiuolo, G., Roffi, L., Babudieri, S., ... Brancaccio, G. (2009). Evolving clinical landscape of chronic hepatitis B: A multicenter Italian study. Journal of Medical Virology, 81, 1999-2006.

Evolving clinical landscape of chronic hepatitis B: A multicenter Italian study. / Almasio, Pier Luigi; Iacomi, Fabio; Stanzione, Maria; Stornaiuolo, Gianfranca; Roffi, Luigi; Babudieri, Sergio; Morisco, Filomena; Pintus, Antonio; Giuberti, Tiziana; Pinzello, Giovanbattista; Ciancio, Alessia; Ferrigno, Luigina; Fagiuoli, Stefano; Mangano, Carmelo; Messina, Vincenzo; Sagnelli, Evangelista; Piccinino, Felice; Fattovich, Giovanna; Chiaramonte, Maria; Smedile, Antonina; Massari, Marco; Antonucci, Giorgio; Caporaso, Nicola; Pastore, Giuseppe; Mele, Alfonso; Caccamo, Gaia; Caserta, Carmelo; Palattella, Stefania; Magnani, Giacomo; Andreone, Pietro; Scuteri, Alessandra; Olivari, Nicola; Bellia, Valentina; Rizzetto, Mario; Brunetto, Maurizia; Sasso, Rodolfo; Gaeta, Giovanni Battista; Lattanzi, Emiliano; Vinci, Maria; Stroffolini, Tommaso; Ferrari, Carlo; Boninsegna, Sara; Raimondo, Giovanni; Brancaccio, Giuseppina.

In: Journal of Medical Virology, Vol. 81, 2009, pag. 1999-2006.

Risultato della ricerca: Article

Almasio, PL, Iacomi, F, Stanzione, M, Stornaiuolo, G, Roffi, L, Babudieri, S, Morisco, F, Pintus, A, Giuberti, T, Pinzello, G, Ciancio, A, Ferrigno, L, Fagiuoli, S, Mangano, C, Messina, V, Sagnelli, E, Piccinino, F, Fattovich, G, Chiaramonte, M, Smedile, A, Massari, M, Antonucci, G, Caporaso, N, Pastore, G, Mele, A, Caccamo, G, Caserta, C, Palattella, S, Magnani, G, Andreone, P, Scuteri, A, Olivari, N, Bellia, V, Rizzetto, M, Brunetto, M, Sasso, R, Gaeta, GB, Lattanzi, E, Vinci, M, Stroffolini, T, Ferrari, C, Boninsegna, S, Raimondo, G & Brancaccio, G 2009, 'Evolving clinical landscape of chronic hepatitis B: A multicenter Italian study.', Journal of Medical Virology, vol. 81, pagg. 1999-2006.
Almasio PL, Iacomi F, Stanzione M, Stornaiuolo G, Roffi L, Babudieri S e altri. Evolving clinical landscape of chronic hepatitis B: A multicenter Italian study. Journal of Medical Virology. 2009;81:1999-2006.
Almasio, Pier Luigi ; Iacomi, Fabio ; Stanzione, Maria ; Stornaiuolo, Gianfranca ; Roffi, Luigi ; Babudieri, Sergio ; Morisco, Filomena ; Pintus, Antonio ; Giuberti, Tiziana ; Pinzello, Giovanbattista ; Ciancio, Alessia ; Ferrigno, Luigina ; Fagiuoli, Stefano ; Mangano, Carmelo ; Messina, Vincenzo ; Sagnelli, Evangelista ; Piccinino, Felice ; Fattovich, Giovanna ; Chiaramonte, Maria ; Smedile, Antonina ; Massari, Marco ; Antonucci, Giorgio ; Caporaso, Nicola ; Pastore, Giuseppe ; Mele, Alfonso ; Caccamo, Gaia ; Caserta, Carmelo ; Palattella, Stefania ; Magnani, Giacomo ; Andreone, Pietro ; Scuteri, Alessandra ; Olivari, Nicola ; Bellia, Valentina ; Rizzetto, Mario ; Brunetto, Maurizia ; Sasso, Rodolfo ; Gaeta, Giovanni Battista ; Lattanzi, Emiliano ; Vinci, Maria ; Stroffolini, Tommaso ; Ferrari, Carlo ; Boninsegna, Sara ; Raimondo, Giovanni ; Brancaccio, Giuseppina. / Evolving clinical landscape of chronic hepatitis B: A multicenter Italian study. In: Journal of Medical Virology. 2009 ; Vol. 81. pagg. 1999-2006.
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abstract = "The aim of the study was to evaluate the characteristics of chronic hepatitis B with special reference to the geographical origin of the patients and to the prevalence of HBeAg and viral and non-viral co-factors of liver disease. A cross-sectional multicenter survey was undertaken, which enrolled 1,386 HBsAg chronic carriers observed consecutively in 21 referral centers over a 6-month period. The prevalence of HBeAg in patients was 11{\%}; the presence of HBeAg was associated independently with a younger age and co-infection with HIV. Anti-HDV, anti-HCV, or anti-HIV antibodies were detected in 8.1{\%}, 6.5{\%}, and 2{\%}, respectively. However, among the patients first diagnosed during the study period (incident cases), 14.3{\%} were anti-HDV positive. Seven percent of the patients were immigrants; they were younger than Italian patients and 18{\%} were HBeAg positive; no difference was observed in the prevalence of anti-HDV, anti-HCV, or anti-HIV antibodies. The presence of cirrhosis was associated independently with an age >52 years, the presence of anti-HDV or anti-HCV, alcohol use >4 drinks/day, and a high BMI. The clinical epidemiology of chronic hepatitis B virus (HBV) infection shows a dynamic profile, with the potential for re-emergence of cases with HBeAg or anti-HDV and an emerging impact of metabolic factors on the evolution of liver disease.",
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T1 - Evolving clinical landscape of chronic hepatitis B: A multicenter Italian study.

AU - Almasio, Pier Luigi

AU - Iacomi, Fabio

AU - Stanzione, Maria

AU - Stornaiuolo, Gianfranca

AU - Roffi, Luigi

AU - Babudieri, Sergio

AU - Morisco, Filomena

AU - Pintus, Antonio

AU - Giuberti, Tiziana

AU - Pinzello, Giovanbattista

AU - Ciancio, Alessia

AU - Ferrigno, Luigina

AU - Fagiuoli, Stefano

AU - Mangano, Carmelo

AU - Messina, Vincenzo

AU - Sagnelli, Evangelista

AU - Piccinino, Felice

AU - Fattovich, Giovanna

AU - Chiaramonte, Maria

AU - Smedile, Antonina

AU - Massari, Marco

AU - Antonucci, Giorgio

AU - Caporaso, Nicola

AU - Pastore, Giuseppe

AU - Mele, Alfonso

AU - Caccamo, Gaia

AU - Caserta, Carmelo

AU - Palattella, Stefania

AU - Magnani, Giacomo

AU - Andreone, Pietro

AU - Scuteri, Alessandra

AU - Olivari, Nicola

AU - Bellia, Valentina

AU - Rizzetto, Mario

AU - Brunetto, Maurizia

AU - Sasso, Rodolfo

AU - Gaeta, Giovanni Battista

AU - Lattanzi, Emiliano

AU - Vinci, Maria

AU - Stroffolini, Tommaso

AU - Ferrari, Carlo

AU - Boninsegna, Sara

AU - Raimondo, Giovanni

AU - Brancaccio, Giuseppina

PY - 2009

Y1 - 2009

N2 - The aim of the study was to evaluate the characteristics of chronic hepatitis B with special reference to the geographical origin of the patients and to the prevalence of HBeAg and viral and non-viral co-factors of liver disease. A cross-sectional multicenter survey was undertaken, which enrolled 1,386 HBsAg chronic carriers observed consecutively in 21 referral centers over a 6-month period. The prevalence of HBeAg in patients was 11%; the presence of HBeAg was associated independently with a younger age and co-infection with HIV. Anti-HDV, anti-HCV, or anti-HIV antibodies were detected in 8.1%, 6.5%, and 2%, respectively. However, among the patients first diagnosed during the study period (incident cases), 14.3% were anti-HDV positive. Seven percent of the patients were immigrants; they were younger than Italian patients and 18% were HBeAg positive; no difference was observed in the prevalence of anti-HDV, anti-HCV, or anti-HIV antibodies. The presence of cirrhosis was associated independently with an age >52 years, the presence of anti-HDV or anti-HCV, alcohol use >4 drinks/day, and a high BMI. The clinical epidemiology of chronic hepatitis B virus (HBV) infection shows a dynamic profile, with the potential for re-emergence of cases with HBeAg or anti-HDV and an emerging impact of metabolic factors on the evolution of liver disease.

AB - The aim of the study was to evaluate the characteristics of chronic hepatitis B with special reference to the geographical origin of the patients and to the prevalence of HBeAg and viral and non-viral co-factors of liver disease. A cross-sectional multicenter survey was undertaken, which enrolled 1,386 HBsAg chronic carriers observed consecutively in 21 referral centers over a 6-month period. The prevalence of HBeAg in patients was 11%; the presence of HBeAg was associated independently with a younger age and co-infection with HIV. Anti-HDV, anti-HCV, or anti-HIV antibodies were detected in 8.1%, 6.5%, and 2%, respectively. However, among the patients first diagnosed during the study period (incident cases), 14.3% were anti-HDV positive. Seven percent of the patients were immigrants; they were younger than Italian patients and 18% were HBeAg positive; no difference was observed in the prevalence of anti-HDV, anti-HCV, or anti-HIV antibodies. The presence of cirrhosis was associated independently with an age >52 years, the presence of anti-HDV or anti-HCV, alcohol use >4 drinks/day, and a high BMI. The clinical epidemiology of chronic hepatitis B virus (HBV) infection shows a dynamic profile, with the potential for re-emergence of cases with HBeAg or anti-HDV and an emerging impact of metabolic factors on the evolution of liver disease.

KW - HBV, hepatitis, epidemiology

UR - http://hdl.handle.net/10447/44244

M3 - Article

VL - 81

SP - 1999

EP - 2006

JO - Journal of Medical Virology

JF - Journal of Medical Virology

SN - 0146-6615

ER -