Evolution of transmitted HIV-1 drug resistance in HIV-1-infected patients in Italy from 2000 to 2010

Salvatrice Mancuso, Colafigli, Simona Di Giambenedetto, Angela Gonnelli, Giovanni Penco, Paola Corsi, Manca, Carlo Torti, Patrizia Bagnarelli, Valeria Micheli, Cauda, Laura Monno, Grazia Punzi, Trecarichi, Rosi, Albini, Parruti, Bruzzone

Risultato della ricerca: Article

22 Citazioni (Scopus)

Abstract

Prevalence and predictors of transmitted drug resistance (TDR), defined as the presence of at least one WHO surveillance drug resistance mutation (SDRM), were investigated in antiretroviral-naïve HIV-1-infected patients, with a genotypic resistance test (GRT) performed ≤6months before starting cART between 2000 and 2010. 3163 HIV-1 sequences were selected (69% subtype B). Overall, the prevalence of TDR was 12% (13.2% subtype B, 9% non-B). TDR significantly declined overall and for the single drug classes. Older age independently predicted increased odds of TDR, whereas a more recent GRT, a higher HIV-RNA and C vs. B subtype predicted lower odds of TDR. © 2012 The Authors. Clinical Microbiology and Infection © 2012 European Society of Clinical Microbiology and Infectious Diseases.
Lingua originaleEnglish
pagine (da-a)E299-E304
Numero di pagine6
RivistaClinical Microbiology and Infection
Volume18
Stato di pubblicazionePublished - 2012

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Drug Resistance
Italy
HIV-1
Microbiology
HIV
RNA
Mutation
Infection
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

Cita questo

Mancuso, S., Colafigli, Di Giambenedetto, S., Gonnelli, A., Penco, G., Corsi, P., ... Bruzzone (2012). Evolution of transmitted HIV-1 drug resistance in HIV-1-infected patients in Italy from 2000 to 2010. Clinical Microbiology and Infection, 18, E299-E304.

Evolution of transmitted HIV-1 drug resistance in HIV-1-infected patients in Italy from 2000 to 2010. / Mancuso, Salvatrice; Colafigli; Di Giambenedetto, Simona; Gonnelli, Angela; Penco, Giovanni; Corsi, Paola; Manca; Torti, Carlo; Bagnarelli, Patrizia; Micheli, Valeria; Cauda; Monno, Laura; Punzi, Grazia; Trecarichi; Rosi; Albini; Parruti; Bruzzone.

In: Clinical Microbiology and Infection, Vol. 18, 2012, pag. E299-E304.

Risultato della ricerca: Article

Mancuso, S, Colafigli, Di Giambenedetto, S, Gonnelli, A, Penco, G, Corsi, P, Manca, Torti, C, Bagnarelli, P, Micheli, V, Cauda, Monno, L, Punzi, G, Trecarichi, Rosi, Albini, Parruti & Bruzzone 2012, 'Evolution of transmitted HIV-1 drug resistance in HIV-1-infected patients in Italy from 2000 to 2010', Clinical Microbiology and Infection, vol. 18, pagg. E299-E304.
Mancuso, Salvatrice ; Colafigli ; Di Giambenedetto, Simona ; Gonnelli, Angela ; Penco, Giovanni ; Corsi, Paola ; Manca ; Torti, Carlo ; Bagnarelli, Patrizia ; Micheli, Valeria ; Cauda ; Monno, Laura ; Punzi, Grazia ; Trecarichi ; Rosi ; Albini ; Parruti ; Bruzzone. / Evolution of transmitted HIV-1 drug resistance in HIV-1-infected patients in Italy from 2000 to 2010. In: Clinical Microbiology and Infection. 2012 ; Vol. 18. pagg. E299-E304.
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abstract = "Prevalence and predictors of transmitted drug resistance (TDR), defined as the presence of at least one WHO surveillance drug resistance mutation (SDRM), were investigated in antiretroviral-na{\"i}ve HIV-1-infected patients, with a genotypic resistance test (GRT) performed ≤6months before starting cART between 2000 and 2010. 3163 HIV-1 sequences were selected (69{\%} subtype B). Overall, the prevalence of TDR was 12{\%} (13.2{\%} subtype B, 9{\%} non-B). TDR significantly declined overall and for the single drug classes. Older age independently predicted increased odds of TDR, whereas a more recent GRT, a higher HIV-RNA and C vs. B subtype predicted lower odds of TDR. {\circledC} 2012 The Authors. Clinical Microbiology and Infection {\circledC} 2012 European Society of Clinical Microbiology and Infectious Diseases.",
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T1 - Evolution of transmitted HIV-1 drug resistance in HIV-1-infected patients in Italy from 2000 to 2010

AU - Mancuso, Salvatrice

AU - Colafigli, null

AU - Di Giambenedetto, Simona

AU - Gonnelli, Angela

AU - Penco, Giovanni

AU - Corsi, Paola

AU - Manca, null

AU - Torti, Carlo

AU - Bagnarelli, Patrizia

AU - Micheli, Valeria

AU - Cauda, null

AU - Monno, Laura

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AU - Rosi, null

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AU - Parruti, null

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AB - Prevalence and predictors of transmitted drug resistance (TDR), defined as the presence of at least one WHO surveillance drug resistance mutation (SDRM), were investigated in antiretroviral-naïve HIV-1-infected patients, with a genotypic resistance test (GRT) performed ≤6months before starting cART between 2000 and 2010. 3163 HIV-1 sequences were selected (69% subtype B). Overall, the prevalence of TDR was 12% (13.2% subtype B, 9% non-B). TDR significantly declined overall and for the single drug classes. Older age independently predicted increased odds of TDR, whereas a more recent GRT, a higher HIV-RNA and C vs. B subtype predicted lower odds of TDR. © 2012 The Authors. Clinical Microbiology and Infection © 2012 European Society of Clinical Microbiology and Infectious Diseases.

KW - Antiretroviral therapy; Chronic HIV infection; Recent HIV infection; Resistance epidemiology; Transmitted resistance; Adult; Anti-HIV Agents; Female; Genotype; HIV Infections; HIV-1; Humans; Italy; Male; Middle Aged; Prevalence; Drug Resistance, Viral; Ev

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