TY - JOUR
T1 - Evolution of transmitted HIV-1 drug resistance in HIV-1-infected patients in Italy from 2000 to 2010
AU - Mancuso, Salvatrice
AU - Trecarichi, null
AU - Rosi, null
AU - Albini, null
AU - Parruti, null
AU - Bruzzone, null
AU - Trecarichi, Enrico Maria
AU - Trecarichi, null
AU - Colafigli, null
AU - Di Giambenedetto, Simona
AU - Gonnelli, Angela
AU - Penco, Giovanni
AU - Corsi, Paola
AU - Manca, null
AU - Torti, Carlo
AU - Bagnarelli, Patrizia
AU - Micheli, Valeria
AU - Cauda, null
AU - Monno, Laura
AU - Punzi, Grazia
PY - 2012
Y1 - 2012
N2 - Prevalence and predictors of transmitted drug resistance (TDR), defined as the presence of at least one WHO surveillance drug resistance mutation (SDRM), were investigated in antiretroviral-naïve HIV-1-infected patients, with a genotypic resistance test (GRT) performed ≤6months before starting cART between 2000 and 2010. 3163 HIV-1 sequences were selected (69% subtype B). Overall, the prevalence of TDR was 12% (13.2% subtype B, 9% non-B). TDR significantly declined overall and for the single drug classes. Older age independently predicted increased odds of TDR, whereas a more recent GRT, a higher HIV-RNA and C vs. B subtype predicted lower odds of TDR. © 2012 The Authors. Clinical Microbiology and Infection © 2012 European Society of Clinical Microbiology and Infectious Diseases.
AB - Prevalence and predictors of transmitted drug resistance (TDR), defined as the presence of at least one WHO surveillance drug resistance mutation (SDRM), were investigated in antiretroviral-naïve HIV-1-infected patients, with a genotypic resistance test (GRT) performed ≤6months before starting cART between 2000 and 2010. 3163 HIV-1 sequences were selected (69% subtype B). Overall, the prevalence of TDR was 12% (13.2% subtype B, 9% non-B). TDR significantly declined overall and for the single drug classes. Older age independently predicted increased odds of TDR, whereas a more recent GRT, a higher HIV-RNA and C vs. B subtype predicted lower odds of TDR. © 2012 The Authors. Clinical Microbiology and Infection © 2012 European Society of Clinical Microbiology and Infectious Diseases.
KW - Antiretroviral therapy; Chronic HIV infection; Recent HIV infection; Resistance epidemiology; Transmitted resistance; Adult; Anti-HIV Agents; Female; Genotype; HIV Infections; HIV-1; Humans; Italy; Male; Middle Aged; Prevalence; Drug Resistance
KW - Molecular; Microbiology (medical); Infectious Diseases
KW - Viral; Evolution
KW - Antiretroviral therapy; Chronic HIV infection; Recent HIV infection; Resistance epidemiology; Transmitted resistance; Adult; Anti-HIV Agents; Female; Genotype; HIV Infections; HIV-1; Humans; Italy; Male; Middle Aged; Prevalence; Drug Resistance
KW - Molecular; Microbiology (medical); Infectious Diseases
KW - Viral; Evolution
UR - http://hdl.handle.net/10447/215818
M3 - Article
VL - 18
SP - E299-E304
JO - Clinical Microbiology and Infection
JF - Clinical Microbiology and Infection
SN - 1198-743X
ER -