Evolution of transmitted HIV-1 drug resistance in HIV-1-infected patients in Italy from 2000 to 2010

Salvatrice Mancuso; null Trecarichi; null Rosi; null Albini; null Parruti; null Bruzzone; null Colafigli; Simona Di Giambenedetto; Angela Gonnelli; Giovanni Penco; Paola Corsi; null Manca; Carlo Torti; Patrizia Bagnarelli; Valeria Micheli; null Cauda; Laura Monno; Grazia Punzi

Evolution of transmitted HIV-1 drug resistance in HIV-1-infected patients in Italy from 2000 to 2010

Salvatrice Mancuso, Trecarichi, Rosi, Albini, Parruti, Bruzzone, Colafigli, Simona Di Giambenedetto, Angela Gonnelli, Giovanni Penco, Paola Corsi, Manca, Carlo Torti, Patrizia Bagnarelli, Valeria Micheli, Cauda, Laura Monno, Grazia Punzi

Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza “G. D’Alessandro”

Risultato della ricerca: Article

23 Citazioni (Scopus)

Abstract

Prevalence and predictors of transmitted drug resistance (TDR), defined as the presence of at least one WHO surveillance drug resistance mutation (SDRM), were investigated in antiretroviral-naïve HIV-1-infected patients, with a genotypic resistance test (GRT) performed ≤6months before starting cART between 2000 and 2010. 3163 HIV-1 sequences were selected (69% subtype B). Overall, the prevalence of TDR was 12% (13.2% subtype B, 9% non-B). TDR significantly declined overall and for the single drug classes. Older age independently predicted increased odds of TDR, whereas a more recent GRT, a higher HIV-RNA and C vs. B subtype predicted lower odds of TDR. © 2012 The Authors. Clinical Microbiology and Infection © 2012 European Society of Clinical Microbiology and Infectious Diseases.

Lingua originale	English
pagine (da-a)	E299-E304
Numero di pagine	6
Rivista	Clinical Microbiology and Infection
Volume	18
Stato di pubblicazione	Published - 2012

All Science Journal Classification (ASJC) codes

Microbiology (medical)
Infectious Diseases

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Mancuso, S., Trecarichi, Rosi, Albini, Parruti, Bruzzone, Colafigli, Di Giambenedetto, S., Gonnelli, A., Penco, G., Corsi, P., Manca, Torti, C., Bagnarelli, P., Micheli, V., Cauda, Monno, L., & Punzi, G. (2012). Evolution of transmitted HIV-1 drug resistance in HIV-1-infected patients in Italy from 2000 to 2010. Clinical Microbiology and Infection, 18, E299-E304.

Evolution of transmitted HIV-1 drug resistance in HIV-1-infected patients in Italy from 2000 to 2010. / Mancuso, Salvatrice; Trecarichi; Rosi; Albini; Parruti; Bruzzone; Colafigli; Di Giambenedetto, Simona; Gonnelli, Angela; Penco, Giovanni; Corsi, Paola; Manca; Torti, Carlo; Bagnarelli, Patrizia; Micheli, Valeria; Cauda; Monno, Laura; Punzi, Grazia.

In: Clinical Microbiology and Infection, Vol. 18, 2012, pag. E299-E304.

Risultato della ricerca: Article

Mancuso, Salvatrice ; Trecarichi ; Rosi ; Albini ; Parruti ; Bruzzone ; Colafigli ; Di Giambenedetto, Simona ; Gonnelli, Angela ; Penco, Giovanni ; Corsi, Paola ; Manca ; Torti, Carlo ; Bagnarelli, Patrizia ; Micheli, Valeria ; Cauda ; Monno, Laura ; Punzi, Grazia. / Evolution of transmitted HIV-1 drug resistance in HIV-1-infected patients in Italy from 2000 to 2010. In: Clinical Microbiology and Infection. 2012 ; Vol. 18. pagg. E299-E304.

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title = "Evolution of transmitted HIV-1 drug resistance in HIV-1-infected patients in Italy from 2000 to 2010",

abstract = "Prevalence and predictors of transmitted drug resistance (TDR), defined as the presence of at least one WHO surveillance drug resistance mutation (SDRM), were investigated in antiretroviral-na{\"i}ve HIV-1-infected patients, with a genotypic resistance test (GRT) performed ≤6months before starting cART between 2000 and 2010. 3163 HIV-1 sequences were selected (69% subtype B). Overall, the prevalence of TDR was 12% (13.2% subtype B, 9% non-B). TDR significantly declined overall and for the single drug classes. Older age independently predicted increased odds of TDR, whereas a more recent GRT, a higher HIV-RNA and C vs. B subtype predicted lower odds of TDR. {\textcopyright} 2012 The Authors. Clinical Microbiology and Infection {\textcopyright} 2012 European Society of Clinical Microbiology and Infectious Diseases.",

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author = "Salvatrice Mancuso and Trecarichi and Rosi and Albini and Parruti and Bruzzone and Colafigli and {Di Giambenedetto}, Simona and Angela Gonnelli and Giovanni Penco and Paola Corsi and Manca and Carlo Torti and Patrizia Bagnarelli and Valeria Micheli and Cauda and Laura Monno and Grazia Punzi",

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AU - Mancuso, Salvatrice

AU - Trecarichi, null

AU - Rosi, null

AU - Albini, null

AU - Parruti, null

AU - Bruzzone, null

AU - Colafigli, null

AU - Di Giambenedetto, Simona

AU - Gonnelli, Angela

AU - Penco, Giovanni

AU - Corsi, Paola

AU - Manca, null

AU - Torti, Carlo

AU - Bagnarelli, Patrizia

AU - Micheli, Valeria

AU - Cauda, null

AU - Monno, Laura

AU - Punzi, Grazia

PY - 2012

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N2 - Prevalence and predictors of transmitted drug resistance (TDR), defined as the presence of at least one WHO surveillance drug resistance mutation (SDRM), were investigated in antiretroviral-naïve HIV-1-infected patients, with a genotypic resistance test (GRT) performed ≤6months before starting cART between 2000 and 2010. 3163 HIV-1 sequences were selected (69% subtype B). Overall, the prevalence of TDR was 12% (13.2% subtype B, 9% non-B). TDR significantly declined overall and for the single drug classes. Older age independently predicted increased odds of TDR, whereas a more recent GRT, a higher HIV-RNA and C vs. B subtype predicted lower odds of TDR. © 2012 The Authors. Clinical Microbiology and Infection © 2012 European Society of Clinical Microbiology and Infectious Diseases.

AB - Prevalence and predictors of transmitted drug resistance (TDR), defined as the presence of at least one WHO surveillance drug resistance mutation (SDRM), were investigated in antiretroviral-naïve HIV-1-infected patients, with a genotypic resistance test (GRT) performed ≤6months before starting cART between 2000 and 2010. 3163 HIV-1 sequences were selected (69% subtype B). Overall, the prevalence of TDR was 12% (13.2% subtype B, 9% non-B). TDR significantly declined overall and for the single drug classes. Older age independently predicted increased odds of TDR, whereas a more recent GRT, a higher HIV-RNA and C vs. B subtype predicted lower odds of TDR. © 2012 The Authors. Clinical Microbiology and Infection © 2012 European Society of Clinical Microbiology and Infectious Diseases.

KW - Antiretroviral therapy; Chronic HIV infection; Recent HIV infection; Resistance epidemiology; Transmitted resistance; Adult; Anti-HIV Agents; Female; Genotype; HIV Infections; HIV-1; Humans; Italy; Male; Middle Aged; Prevalence; Drug Resistance

KW - Molecular; Microbiology (medical); Infectious Diseases

KW - Viral; Evolution

KW - Antiretroviral therapy; Chronic HIV infection; Recent HIV infection; Resistance epidemiology; Transmitted resistance; Adult; Anti-HIV Agents; Female; Genotype; HIV Infections; HIV-1; Humans; Italy; Male; Middle Aged; Prevalence; Drug Resistance

KW - Molecular; Microbiology (medical); Infectious Diseases

KW - Viral; Evolution

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