Evolution of transmitted HIV-1 drug resistance in HIV-1-infected patients in Italy from 2000 to 2010

Salvatrice Mancuso, Trecarichi, Rosi, Albini, Parruti, Bruzzone, Colafigli, Simona Di Giambenedetto, Angela Gonnelli, Giovanni Penco, Paola Corsi, Manca, Carlo Torti, Patrizia Bagnarelli, Valeria Micheli, Cauda, Laura Monno, Grazia Punzi

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23 Citazioni (Scopus)

Abstract

Prevalence and predictors of transmitted drug resistance (TDR), defined as the presence of at least one WHO surveillance drug resistance mutation (SDRM), were investigated in antiretroviral-naïve HIV-1-infected patients, with a genotypic resistance test (GRT) performed ≤6months before starting cART between 2000 and 2010. 3163 HIV-1 sequences were selected (69% subtype B). Overall, the prevalence of TDR was 12% (13.2% subtype B, 9% non-B). TDR significantly declined overall and for the single drug classes. Older age independently predicted increased odds of TDR, whereas a more recent GRT, a higher HIV-RNA and C vs. B subtype predicted lower odds of TDR. © 2012 The Authors. Clinical Microbiology and Infection © 2012 European Society of Clinical Microbiology and Infectious Diseases.
Lingua originaleEnglish
pagine (da-a)E299-E304
Numero di pagine6
RivistaClinical Microbiology and Infection
Volume18
Stato di pubblicazionePublished - 2012

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

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    Mancuso, S., Trecarichi, Rosi, Albini, Parruti, Bruzzone, Colafigli, Di Giambenedetto, S., Gonnelli, A., Penco, G., Corsi, P., Manca, Torti, C., Bagnarelli, P., Micheli, V., Cauda, Monno, L., & Punzi, G. (2012). Evolution of transmitted HIV-1 drug resistance in HIV-1-infected patients in Italy from 2000 to 2010. Clinical Microbiology and Infection, 18, E299-E304.