Evolution and Immune Function of Fish Lectins

Risultato della ricerca: Chapter

2 Citazioni (Scopus)

Abstract

Lectins are sugar-binding proteins widely distributed among animals, plants, and microbial taxon, involved in diverse biological processes. In both invertebrates and vertebrates, they play key roles in nonself recognition and immune responses, such as nonself recognition, inflammatory processes, and immunomodulation. In fish, many lectin families have been identified, and their tissue-specific expression and localization of the various lectin repertoires and their ligands are consistent with their distinct biological roles in innate and adaptive immunity. Here, we discuss the involvement of F-type lectins, rhamnose-binding lectins, galectins, and C-type lectins in pathogen recognition and opsonization through the binding of endogenous and exogenous ligands and their additional effector roles, such as complement activation and regulation of immune functions. These lectin families, identified and characterized in fish, appear to be involved in nonself recognition, inflammatory reaction, and immunomodulation processes. Function and phylogenetic history of these lectin families are also described.
Lingua originaleEnglish
Titolo della pubblicazione ospiteLessons in immunity
Numero di pagine23
Stato di pubblicazionePublished - 2016

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Lectins
Immunomodulation
Fishes
Galectins
Ligands
C-Type Lectins
Biological Phenomena
Rhamnose
Complement Activation
Adaptive Immunity
Invertebrates
Innate Immunity
Vertebrates
Carrier Proteins

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Immunology and Microbiology(all)

Cita questo

Parisi, M. G., Cammarata, M., & Vasta, G. R. (2016). Evolution and Immune Function of Fish Lectins. In Lessons in immunity

Evolution and Immune Function of Fish Lectins. / Parisi, Maria Giovanna; Cammarata, Matteo; Vasta, Gerardo R.

Lessons in immunity. 2016.

Risultato della ricerca: Chapter

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AB - Lectins are sugar-binding proteins widely distributed among animals, plants, and microbial taxon, involved in diverse biological processes. In both invertebrates and vertebrates, they play key roles in nonself recognition and immune responses, such as nonself recognition, inflammatory processes, and immunomodulation. In fish, many lectin families have been identified, and their tissue-specific expression and localization of the various lectin repertoires and their ligands are consistent with their distinct biological roles in innate and adaptive immunity. Here, we discuss the involvement of F-type lectins, rhamnose-binding lectins, galectins, and C-type lectins in pathogen recognition and opsonization through the binding of endogenous and exogenous ligands and their additional effector roles, such as complement activation and regulation of immune functions. These lectin families, identified and characterized in fish, appear to be involved in nonself recognition, inflammatory reaction, and immunomodulation processes. Function and phylogenetic history of these lectin families are also described.

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