Evidences of cervical cancer stem cells derived from established cell lines.

Giorgio Stassi, Matilde Todaro, Ylenia Lombardo, Giorgio Stassi

Risultato della ricerca: Article

6 Citazioni (Scopus)

Abstract

According to the longstanding “clonal evolution”model of carcinogenesis, cervicalcarcinoma has long been described as a consequenceof unlimited and uncontrolled cellularproliferation conferred by multiple geneticand/or epigenetic mutations that can hit anysomatic cells within the tissue. However, inthe last few years, accumulating evidence hassuggested that the capacity of initiating atumor, including cervical carcinoma, is rathera unique feature of a small subset of stemlikecells called “cancer stem cells” (CSCs) or“tumor-initiating cells.” CSCs have the exclusiveability to self-renew expanding the CSCs pool,and to maintain the tumor differentiating intothe heterogeneous non tumorigenic cancercell types which constitute the majority withinthe tumor.1Although solid evidence is lacking to date,subcolumnar reserve cells emerged to be thebest candidate for cervical stem cells, whichprovide a depository for the regeneration ofthe mucous-forming epithelium. S
Lingua originaleEnglish
pagine (da-a)1238-1239
Numero di pagine2
RivistaCell Cycle
Volume2010-04-01
Stato di pubblicazionePublished - 2010

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Neoplastic Stem Cells
Uterine Cervical Neoplasms
Cell Line
Epigenomics
Regeneration
Carcinogenesis
Stem Cells
Epithelium
Carcinoma
Mutation
Neoplasms

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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Evidences of cervical cancer stem cells derived from established cell lines. / Stassi, Giorgio; Todaro, Matilde; Lombardo, Ylenia; Stassi, Giorgio.

In: Cell Cycle, Vol. 2010-04-01, 2010, pag. 1238-1239.

Risultato della ricerca: Article

Stassi, G, Todaro, M, Lombardo, Y & Stassi, G 2010, 'Evidences of cervical cancer stem cells derived from established cell lines.', Cell Cycle, vol. 2010-04-01, pagg. 1238-1239.
Stassi, Giorgio ; Todaro, Matilde ; Lombardo, Ylenia ; Stassi, Giorgio. / Evidences of cervical cancer stem cells derived from established cell lines. In: Cell Cycle. 2010 ; Vol. 2010-04-01. pagg. 1238-1239.
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AB - According to the longstanding “clonal evolution”model of carcinogenesis, cervicalcarcinoma has long been described as a consequenceof unlimited and uncontrolled cellularproliferation conferred by multiple geneticand/or epigenetic mutations that can hit anysomatic cells within the tissue. However, inthe last few years, accumulating evidence hassuggested that the capacity of initiating atumor, including cervical carcinoma, is rathera unique feature of a small subset of stemlikecells called “cancer stem cells” (CSCs) or“tumor-initiating cells.” CSCs have the exclusiveability to self-renew expanding the CSCs pool,and to maintain the tumor differentiating intothe heterogeneous non tumorigenic cancercell types which constitute the majority withinthe tumor.1Although solid evidence is lacking to date,subcolumnar reserve cells emerged to be thebest candidate for cervical stem cells, whichprovide a depository for the regeneration ofthe mucous-forming epithelium. S

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