Evidences of cervical cancer stem cells derived from established cell lines.

Giorgio Stassi, Matilde Todaro, Giorgio Stassi, Ylenia Lombardo

Risultato della ricerca: Article

6 Citazioni (Scopus)

Abstract

According to the longstanding “clonal evolution” model of carcinogenesis, cervical carcinoma has long been described as a consequence of unlimited and uncontrolled cellular proliferation conferred by multiple genetic and/or epigenetic mutations that can hit any somatic cells within the tissue. However, in the last few years, accumulating evidence has suggested that the capacity of initiating a tumor, including cervical carcinoma, is rather a unique feature of a small subset of stemlike cells called “cancer stem cells” (CSCs) or “tumor-initiating cells.” CSCs have the exclusive ability to self-renew expanding the CSCs pool, and to maintain the tumor differentiating into the heterogeneous non tumorigenic cancer cell types which constitute the majority within the tumor.1 Although solid evidence is lacking to date, subcolumnar reserve cells emerged to be the best candidate for cervical stem cells, which provide a depository for the regeneration of the mucous-forming epithelium. S
Lingua originaleEnglish
pagine (da-a)1238-1239
Numero di pagine2
RivistaCell Cycle
Volume2010-04-01
Stato di pubblicazionePublished - 2010

Fingerprint

Neoplastic Stem Cells
Uterine Cervical Neoplasms
Cell Line
Clonal Evolution
Epigenomics
Regeneration
Carcinogenesis
Stem Cells
Epithelium
Carcinoma
Mutation
Neoplasms

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology
  • Developmental Biology

Cita questo

Evidences of cervical cancer stem cells derived from established cell lines. / Stassi, Giorgio; Todaro, Matilde; Stassi, Giorgio; Lombardo, Ylenia.

In: Cell Cycle, Vol. 2010-04-01, 2010, pag. 1238-1239.

Risultato della ricerca: Article

Stassi, G, Todaro, M, Stassi, G & Lombardo, Y 2010, 'Evidences of cervical cancer stem cells derived from established cell lines.', Cell Cycle, vol. 2010-04-01, pagg. 1238-1239.
Stassi, Giorgio ; Todaro, Matilde ; Stassi, Giorgio ; Lombardo, Ylenia. / Evidences of cervical cancer stem cells derived from established cell lines. In: Cell Cycle. 2010 ; Vol. 2010-04-01. pagg. 1238-1239.
@article{3e38bf6727694d488649c316d6fd84fb,
title = "Evidences of cervical cancer stem cells derived from established cell lines.",
abstract = "According to the longstanding “clonal evolution” model of carcinogenesis, cervical carcinoma has long been described as a consequence of unlimited and uncontrolled cellular proliferation conferred by multiple genetic and/or epigenetic mutations that can hit any somatic cells within the tissue. However, in the last few years, accumulating evidence has suggested that the capacity of initiating a tumor, including cervical carcinoma, is rather a unique feature of a small subset of stemlike cells called “cancer stem cells” (CSCs) or “tumor-initiating cells.” CSCs have the exclusive ability to self-renew expanding the CSCs pool, and to maintain the tumor differentiating into the heterogeneous non tumorigenic cancer cell types which constitute the majority within the tumor.1 Although solid evidence is lacking to date, subcolumnar reserve cells emerged to be the best candidate for cervical stem cells, which provide a depository for the regeneration of the mucous-forming epithelium. S",
keywords = "cervical cancer stem, CD44, EMT",
author = "Giorgio Stassi and Matilde Todaro and Giorgio Stassi and Ylenia Lombardo",
year = "2010",
language = "English",
volume = "2010-04-01",
pages = "1238--1239",
journal = "Cell Cycle",
issn = "1538-4101",
publisher = "Landes Bioscience",

}

TY - JOUR

T1 - Evidences of cervical cancer stem cells derived from established cell lines.

AU - Stassi, Giorgio

AU - Todaro, Matilde

AU - Stassi, Giorgio

AU - Lombardo, Ylenia

PY - 2010

Y1 - 2010

N2 - According to the longstanding “clonal evolution” model of carcinogenesis, cervical carcinoma has long been described as a consequence of unlimited and uncontrolled cellular proliferation conferred by multiple genetic and/or epigenetic mutations that can hit any somatic cells within the tissue. However, in the last few years, accumulating evidence has suggested that the capacity of initiating a tumor, including cervical carcinoma, is rather a unique feature of a small subset of stemlike cells called “cancer stem cells” (CSCs) or “tumor-initiating cells.” CSCs have the exclusive ability to self-renew expanding the CSCs pool, and to maintain the tumor differentiating into the heterogeneous non tumorigenic cancer cell types which constitute the majority within the tumor.1 Although solid evidence is lacking to date, subcolumnar reserve cells emerged to be the best candidate for cervical stem cells, which provide a depository for the regeneration of the mucous-forming epithelium. S

AB - According to the longstanding “clonal evolution” model of carcinogenesis, cervical carcinoma has long been described as a consequence of unlimited and uncontrolled cellular proliferation conferred by multiple genetic and/or epigenetic mutations that can hit any somatic cells within the tissue. However, in the last few years, accumulating evidence has suggested that the capacity of initiating a tumor, including cervical carcinoma, is rather a unique feature of a small subset of stemlike cells called “cancer stem cells” (CSCs) or “tumor-initiating cells.” CSCs have the exclusive ability to self-renew expanding the CSCs pool, and to maintain the tumor differentiating into the heterogeneous non tumorigenic cancer cell types which constitute the majority within the tumor.1 Although solid evidence is lacking to date, subcolumnar reserve cells emerged to be the best candidate for cervical stem cells, which provide a depository for the regeneration of the mucous-forming epithelium. S

KW - cervical cancer stem, CD44, EMT

UR - http://hdl.handle.net/10447/50074

M3 - Article

VL - 2010-04-01

SP - 1238

EP - 1239

JO - Cell Cycle

JF - Cell Cycle

SN - 1538-4101

ER -