Evidence of unbalanced regulatory mechanism of heart rate and systolic pressure after acute myocardial infarction

Luca Faes, Luca Faes, Flavia Ravelli, Maurizio Del Greco, Giandomenico Nollo, Barbara Pellegrini, Alberto Porta, Marcello Disertori, Renzo Antolini

Risultato della ricerca: Article

52 Citazioni (Scopus)

Abstract

The interactions between systolic arterial pressure (SAP) and R-R interval (RR) fluctuations after acute myocardial infarction (AMI) were investigated by measures of synchronization separating the feedback from the feedforward control and capturing both linear and nonlinear contributions. The causal synchronization, evaluating the ability of RR to predict SAP (Xs/t) or vice versa (Xt/s), and the global synchronization (X) were estimated at rest and after head-up tilt in 35 post-AMI patients, 20 young and 12 old. Significance and nonlinearity of the coupling were assessed by surrogate data analysis. Tilting increased the number of young subjects in which RR-SAP link was significant (from 17 to 19) and linear (from 11 to 18). In AMI, both significance and linearity of the coupling were low at rest (26 significant and 24 nonlinear) and further reduced after tilt (17 significant and 16 nonlinear). Old subjects showed a partial recovery of linearity after tilt (rest: 1 linear of 7 significant; tilt: 5 linear of 8 significant). In young subjects, the causal synchronization indexes were balanced and increased from rest (Xt/s = 0.072 ± 0.037 and Xs/t = 0.054 ± 0.028) to tilt (Xt/s = 0.125 ± 0.071 and Xs/t = 0.108 ± 0.053). On the contrary, in old subjects and AMI patients, the feedforward was prevalent to the feedback coupling at rest (old: Xt/s = 0.041 ± 0.023 and Xs/t = 0.069 ± 0.042; AMI: Xt/s = 0.050 ± 0.030 and Xs/t = 0.089 ± 0.053). Tilting blunted the unbalance in old subjects (Xt/s = 0.065 ± 0.052 and Xs/t = 0.069 ± 0.044) but not in AMI patients (Xt/s = 0.040 ± 0.019 and Xs/t = 0.060 ± 0.040). Thus, after AMI, nonlinear mechanisms are elicited in RR-SAP interactions. Furthermore, the neural regulation of the cardiovascular system resulted in imbalance as a consequence of impaired feedback and enhanced feedforward control mechanisms.
Lingua originaleEnglish
pagine (da-a)H1200-H1207
Numero di pagine8
RivistaAMERICAN JOURNAL OF PHYSIOLOGY. HEART AND CIRCULATORY PHYSIOLOGY
Volume283
Stato di pubblicazionePublished - 2002

Fingerprint

Heart Rate
Myocardial Infarction
Blood Pressure
Arterial Pressure
Cardiovascular System
Head

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cita questo

Evidence of unbalanced regulatory mechanism of heart rate and systolic pressure after acute myocardial infarction. / Faes, Luca; Faes, Luca; Ravelli, Flavia; Del Greco, Maurizio; Nollo, Giandomenico; Pellegrini, Barbara; Porta, Alberto; Disertori, Marcello; Antolini, Renzo.

In: AMERICAN JOURNAL OF PHYSIOLOGY. HEART AND CIRCULATORY PHYSIOLOGY, Vol. 283, 2002, pag. H1200-H1207.

Risultato della ricerca: Article

Faes, L, Faes, L, Ravelli, F, Del Greco, M, Nollo, G, Pellegrini, B, Porta, A, Disertori, M & Antolini, R 2002, 'Evidence of unbalanced regulatory mechanism of heart rate and systolic pressure after acute myocardial infarction', AMERICAN JOURNAL OF PHYSIOLOGY. HEART AND CIRCULATORY PHYSIOLOGY, vol. 283, pagg. H1200-H1207.
Faes, Luca ; Faes, Luca ; Ravelli, Flavia ; Del Greco, Maurizio ; Nollo, Giandomenico ; Pellegrini, Barbara ; Porta, Alberto ; Disertori, Marcello ; Antolini, Renzo. / Evidence of unbalanced regulatory mechanism of heart rate and systolic pressure after acute myocardial infarction. In: AMERICAN JOURNAL OF PHYSIOLOGY. HEART AND CIRCULATORY PHYSIOLOGY. 2002 ; Vol. 283. pagg. H1200-H1207.
@article{77a0404dd14c4580b51fbead44ad489a,
title = "Evidence of unbalanced regulatory mechanism of heart rate and systolic pressure after acute myocardial infarction",
abstract = "The interactions between systolic arterial pressure (SAP) and R-R interval (RR) fluctuations after acute myocardial infarction (AMI) were investigated by measures of synchronization separating the feedback from the feedforward control and capturing both linear and nonlinear contributions. The causal synchronization, evaluating the ability of RR to predict SAP (Xs/t) or vice versa (Xt/s), and the global synchronization (X) were estimated at rest and after head-up tilt in 35 post-AMI patients, 20 young and 12 old. Significance and nonlinearity of the coupling were assessed by surrogate data analysis. Tilting increased the number of young subjects in which RR-SAP link was significant (from 17 to 19) and linear (from 11 to 18). In AMI, both significance and linearity of the coupling were low at rest (26 significant and 24 nonlinear) and further reduced after tilt (17 significant and 16 nonlinear). Old subjects showed a partial recovery of linearity after tilt (rest: 1 linear of 7 significant; tilt: 5 linear of 8 significant). In young subjects, the causal synchronization indexes were balanced and increased from rest (Xt/s = 0.072 {\^A}± 0.037 and Xs/t = 0.054 {\^A}± 0.028) to tilt (Xt/s = 0.125 {\^A}± 0.071 and Xs/t = 0.108 {\^A}± 0.053). On the contrary, in old subjects and AMI patients, the feedforward was prevalent to the feedback coupling at rest (old: Xt/s = 0.041 {\^A}± 0.023 and Xs/t = 0.069 {\^A}± 0.042; AMI: Xt/s = 0.050 {\^A}± 0.030 and Xs/t = 0.089 {\^A}± 0.053). Tilting blunted the unbalance in old subjects (Xt/s = 0.065 {\^A}± 0.052 and Xs/t = 0.069 {\^A}± 0.044) but not in AMI patients (Xt/s = 0.040 {\^A}± 0.019 and Xs/t = 0.060 {\^A}± 0.040). Thus, after AMI, nonlinear mechanisms are elicited in RR-SAP interactions. Furthermore, the neural regulation of the cardiovascular system resulted in imbalance as a consequence of impaired feedback and enhanced feedforward control mechanisms.",
keywords = "Baroreflex regulation, Causal analysis, Nonlinear coupling, Physiology, Synchronization",
author = "Luca Faes and Luca Faes and Flavia Ravelli and {Del Greco}, Maurizio and Giandomenico Nollo and Barbara Pellegrini and Alberto Porta and Marcello Disertori and Renzo Antolini",
year = "2002",
language = "English",
volume = "283",
pages = "H1200--H1207",
journal = "American Journal of Physiology - Heart and Circulatory Physiology",
issn = "0363-6135",
publisher = "American Physiological Society",

}

TY - JOUR

T1 - Evidence of unbalanced regulatory mechanism of heart rate and systolic pressure after acute myocardial infarction

AU - Faes, Luca

AU - Faes, Luca

AU - Ravelli, Flavia

AU - Del Greco, Maurizio

AU - Nollo, Giandomenico

AU - Pellegrini, Barbara

AU - Porta, Alberto

AU - Disertori, Marcello

AU - Antolini, Renzo

PY - 2002

Y1 - 2002

N2 - The interactions between systolic arterial pressure (SAP) and R-R interval (RR) fluctuations after acute myocardial infarction (AMI) were investigated by measures of synchronization separating the feedback from the feedforward control and capturing both linear and nonlinear contributions. The causal synchronization, evaluating the ability of RR to predict SAP (Xs/t) or vice versa (Xt/s), and the global synchronization (X) were estimated at rest and after head-up tilt in 35 post-AMI patients, 20 young and 12 old. Significance and nonlinearity of the coupling were assessed by surrogate data analysis. Tilting increased the number of young subjects in which RR-SAP link was significant (from 17 to 19) and linear (from 11 to 18). In AMI, both significance and linearity of the coupling were low at rest (26 significant and 24 nonlinear) and further reduced after tilt (17 significant and 16 nonlinear). Old subjects showed a partial recovery of linearity after tilt (rest: 1 linear of 7 significant; tilt: 5 linear of 8 significant). In young subjects, the causal synchronization indexes were balanced and increased from rest (Xt/s = 0.072 ± 0.037 and Xs/t = 0.054 ± 0.028) to tilt (Xt/s = 0.125 ± 0.071 and Xs/t = 0.108 ± 0.053). On the contrary, in old subjects and AMI patients, the feedforward was prevalent to the feedback coupling at rest (old: Xt/s = 0.041 ± 0.023 and Xs/t = 0.069 ± 0.042; AMI: Xt/s = 0.050 ± 0.030 and Xs/t = 0.089 ± 0.053). Tilting blunted the unbalance in old subjects (Xt/s = 0.065 ± 0.052 and Xs/t = 0.069 ± 0.044) but not in AMI patients (Xt/s = 0.040 ± 0.019 and Xs/t = 0.060 ± 0.040). Thus, after AMI, nonlinear mechanisms are elicited in RR-SAP interactions. Furthermore, the neural regulation of the cardiovascular system resulted in imbalance as a consequence of impaired feedback and enhanced feedforward control mechanisms.

AB - The interactions between systolic arterial pressure (SAP) and R-R interval (RR) fluctuations after acute myocardial infarction (AMI) were investigated by measures of synchronization separating the feedback from the feedforward control and capturing both linear and nonlinear contributions. The causal synchronization, evaluating the ability of RR to predict SAP (Xs/t) or vice versa (Xt/s), and the global synchronization (X) were estimated at rest and after head-up tilt in 35 post-AMI patients, 20 young and 12 old. Significance and nonlinearity of the coupling were assessed by surrogate data analysis. Tilting increased the number of young subjects in which RR-SAP link was significant (from 17 to 19) and linear (from 11 to 18). In AMI, both significance and linearity of the coupling were low at rest (26 significant and 24 nonlinear) and further reduced after tilt (17 significant and 16 nonlinear). Old subjects showed a partial recovery of linearity after tilt (rest: 1 linear of 7 significant; tilt: 5 linear of 8 significant). In young subjects, the causal synchronization indexes were balanced and increased from rest (Xt/s = 0.072 ± 0.037 and Xs/t = 0.054 ± 0.028) to tilt (Xt/s = 0.125 ± 0.071 and Xs/t = 0.108 ± 0.053). On the contrary, in old subjects and AMI patients, the feedforward was prevalent to the feedback coupling at rest (old: Xt/s = 0.041 ± 0.023 and Xs/t = 0.069 ± 0.042; AMI: Xt/s = 0.050 ± 0.030 and Xs/t = 0.089 ± 0.053). Tilting blunted the unbalance in old subjects (Xt/s = 0.065 ± 0.052 and Xs/t = 0.069 ± 0.044) but not in AMI patients (Xt/s = 0.040 ± 0.019 and Xs/t = 0.060 ± 0.040). Thus, after AMI, nonlinear mechanisms are elicited in RR-SAP interactions. Furthermore, the neural regulation of the cardiovascular system resulted in imbalance as a consequence of impaired feedback and enhanced feedforward control mechanisms.

KW - Baroreflex regulation

KW - Causal analysis

KW - Nonlinear coupling

KW - Physiology

KW - Synchronization

UR - http://hdl.handle.net/10447/276977

M3 - Article

VL - 283

SP - H1200-H1207

JO - American Journal of Physiology - Heart and Circulatory Physiology

JF - American Journal of Physiology - Heart and Circulatory Physiology

SN - 0363-6135

ER -