Evidence of cytotoxic activity against mammalian red blood cell of Na+ channel neurotoxin (AE1) from sea anemone (actinia equina)

Risultato della ricerca: Articlepeer review

2 Citazioni (Scopus)

Abstract

The diversification of anthozoan toxins played an important role in the ability to colonize various ecological niches. In this study we evaluated the hemolytic activity of HPLC separated fraction of tentacle extracts of sea anemone Actinia equina. Toxic components from acid tissue tentacle extracts were investigated by size exclusion and reverse phase HPLC to characterize cytolytic molecules. A novel low molecular weight active fraction was sequenced by MALDI TOF analysis and a protein correspondent to 5.4 kDa Sodium channel neurotoxin (Ae1) from A. equina was identified. Synthetic Ae1 was assayed and it showed an hemolytic activity against mammalian erythrocytes in a dose dependent manner. Cytolytic activity in addition to neuro-inhibitory function could be a further property of Ae1 toxin repertoire.
Lingua originaleEnglish
pagine (da-a)309-314
Numero di pagine6
RivistaInvertebrate Survival Journal
Volume13
Stato di pubblicazionePublished - 2016

All Science Journal Classification (ASJC) codes

  • Animal Science and Zoology

Fingerprint Entra nei temi di ricerca di 'Evidence of cytotoxic activity against mammalian red blood cell of Na+ channel neurotoxin (AE1) from sea anemone (actinia equina)'. Insieme formano una fingerprint unica.

Cita questo