Evidence for a novel cytoplasmic processing event in ribosome maturation in the sea urchin Paracentrotus lividus.

Rainero Barbieri, Daniele Bellavia

    Risultato della ricerca: Article

    3 Citazioni (Scopus)

    Abstract

    In this paper we demonstrate the existence of a cytoplasmic processing step, never before described, involving both the pre-ribosomal subunits in the sea urchin Paracentrotus lividus. Northern-blot hybridization, primer extension, S1 mapping experiments and in situ hybridizations allowed us to demonstrate that cytoplasmic processed particles are successively re-imported into the nucleus where maturation of their RNAs is completed prior to being exported to the cytoplasm. Our findings lead to the proposal of a new model of ribosome maturation and shuttling.
    Lingua originaleEnglish
    pagine (da-a)1871-1879
    Numero di pagine9
    RivistaCellular and Molecular Life Sciences
    Stato di pubblicazionePublished - 2010

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    All Science Journal Classification (ASJC) codes

    • Molecular Medicine
    • Molecular Biology
    • Pharmacology
    • Cellular and Molecular Neuroscience
    • Cell Biology

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