Evaluation of ventricular wall stress and cardiac function in patients with dilated cardiomyopathy

Antonino Rinaudo, Francesco Scardulla, Cesare Scardulla, Salvatore Pasta

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    4 Citazioni (Scopus)

    Abstract

    Dilated cardiomyopathy is a heart disease characterized by both left ventricular dilatation and left ventricular systolic dysfunction, leading to cardiac remodeling and ultimately heart failure. We aimed to investigate the effect of dilated cardiomyopathy on the pump performance and myocardial wall mechanics using patient-specific finite element analysis. Results evinced pronounced end-systolic wall stress on left ventricular wall of patients with dilated cardiomyopathy as compared to that of normal hearts. In dilated cardiomyopathy, both end-diastolic and end-systolic pressure-volume relationships of left ventricle and right ventricle were shifted to the right compared to controls, suggesting reduced myocardial contractility. We hereby propose that finite element analysis represents a useful tool to assess the myocardial wall stress and cardiac work, which are responsible for progressive left ventricular deterioration and poor clinical course.
    Lingua originaleEnglish
    pagine (da-a)71-74
    Numero di pagine4
    RivistaPROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS. PART H, JOURNAL OF ENGINEERING IN MEDICINE
    Volume230
    Stato di pubblicazionePublished - 2016

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    Dilated Cardiomyopathy
    Finite Element Analysis
    Heart Ventricles
    Finite element method
    Deterioration
    Mechanics
    Left Ventricular Dysfunction
    Pumps
    Dilatation
    Heart Diseases
    Heart Failure
    Blood Pressure

    All Science Journal Classification (ASJC) codes

    • Medicine(all)
    • Mechanical Engineering

    Cita questo

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    AU - Rinaudo, Antonino

    AU - Scardulla, Francesco

    AU - Scardulla, Cesare

    AU - Pasta, Salvatore

    PY - 2016

    Y1 - 2016

    N2 - Dilated cardiomyopathy is a heart disease characterized by both left ventricular dilatation and left ventricular systolic dysfunction, leading to cardiac remodeling and ultimately heart failure. We aimed to investigate the effect of dilated cardiomyopathy on the pump performance and myocardial wall mechanics using patient-specific finite element analysis. Results evinced pronounced end-systolic wall stress on left ventricular wall of patients with dilated cardiomyopathy as compared to that of normal hearts. In dilated cardiomyopathy, both end-diastolic and end-systolic pressure-volume relationships of left ventricle and right ventricle were shifted to the right compared to controls, suggesting reduced myocardial contractility. We hereby propose that finite element analysis represents a useful tool to assess the myocardial wall stress and cardiac work, which are responsible for progressive left ventricular deterioration and poor clinical course.

    AB - Dilated cardiomyopathy is a heart disease characterized by both left ventricular dilatation and left ventricular systolic dysfunction, leading to cardiac remodeling and ultimately heart failure. We aimed to investigate the effect of dilated cardiomyopathy on the pump performance and myocardial wall mechanics using patient-specific finite element analysis. Results evinced pronounced end-systolic wall stress on left ventricular wall of patients with dilated cardiomyopathy as compared to that of normal hearts. In dilated cardiomyopathy, both end-diastolic and end-systolic pressure-volume relationships of left ventricle and right ventricle were shifted to the right compared to controls, suggesting reduced myocardial contractility. We hereby propose that finite element analysis represents a useful tool to assess the myocardial wall stress and cardiac work, which are responsible for progressive left ventricular deterioration and poor clinical course.

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    JO - Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine

    JF - Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine

    SN - 0954-4119

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