Evaluation of ventricular wall stress and cardiac function in patients with dilated cardiomyopathy

Antonino Rinaudo, Francesco Scardulla, Salvatore Pasta, Cesare Scardulla, Salvatore Pasta

Risultato della ricerca: Article

4 Citazioni (Scopus)

Abstract

Dilated cardiomyopathy is a heart disease characterized by both left ventricular dilatation and left ventricular systolic dysfunction, leading to cardiac remodeling and ultimately heart failure. We aimed to investigate the effect of dilated cardiomyopathy on the pump performance and myocardial wall mechanics using patient-specific finite element analysis. Results evinced pronounced end-systolic wall stress on left ventricular wall of patients with dilated cardiomyopathy as compared to that of normal hearts. In dilated cardiomyopathy, both end-diastolic and end-systolic pressure-volume relationships of left ventricle and right ventricle were shifted to the right compared to controls, suggesting reduced myocardial contractility. We hereby propose that finite element analysis represents a useful tool to assess the myocardial wall stress and cardiac work, which are responsible for progressive left ventricular deterioration and poor clinical course.
Lingua originaleEnglish
pagine (da-a)71-74
Numero di pagine4
RivistaPROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS. PART H, JOURNAL OF ENGINEERING IN MEDICINE
Volume230
Stato di pubblicazionePublished - 2016

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Dilated Cardiomyopathy
Finite Element Analysis
Heart Ventricles
Finite element method
Deterioration
Mechanics
Left Ventricular Dysfunction
Pumps
Dilatation
Heart Diseases
Heart Failure
Blood Pressure

All Science Journal Classification (ASJC) codes

  • Mechanical Engineering

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AU - Rinaudo, Antonino

AU - Scardulla, Francesco

AU - Pasta, Salvatore

AU - Scardulla, Cesare

AU - Pasta, Salvatore

PY - 2016

Y1 - 2016

N2 - Dilated cardiomyopathy is a heart disease characterized by both left ventricular dilatation and left ventricular systolic dysfunction, leading to cardiac remodeling and ultimately heart failure. We aimed to investigate the effect of dilated cardiomyopathy on the pump performance and myocardial wall mechanics using patient-specific finite element analysis. Results evinced pronounced end-systolic wall stress on left ventricular wall of patients with dilated cardiomyopathy as compared to that of normal hearts. In dilated cardiomyopathy, both end-diastolic and end-systolic pressure-volume relationships of left ventricle and right ventricle were shifted to the right compared to controls, suggesting reduced myocardial contractility. We hereby propose that finite element analysis represents a useful tool to assess the myocardial wall stress and cardiac work, which are responsible for progressive left ventricular deterioration and poor clinical course.

AB - Dilated cardiomyopathy is a heart disease characterized by both left ventricular dilatation and left ventricular systolic dysfunction, leading to cardiac remodeling and ultimately heart failure. We aimed to investigate the effect of dilated cardiomyopathy on the pump performance and myocardial wall mechanics using patient-specific finite element analysis. Results evinced pronounced end-systolic wall stress on left ventricular wall of patients with dilated cardiomyopathy as compared to that of normal hearts. In dilated cardiomyopathy, both end-diastolic and end-systolic pressure-volume relationships of left ventricle and right ventricle were shifted to the right compared to controls, suggesting reduced myocardial contractility. We hereby propose that finite element analysis represents a useful tool to assess the myocardial wall stress and cardiac work, which are responsible for progressive left ventricular deterioration and poor clinical course.

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JO - Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine

JF - Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine

SN - 0954-4119

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