TY - JOUR
T1 - Evaluation of the prognostic role of tumour-associated macrophages in newly diagnosed classical hodgkin lymphoma and correlation with early FDG-PET assessment
AU - Mancuso, Salvatrice
AU - Lazzi, Stefano
AU - Cencini, Emanuele
AU - Cox, Maria Christina
AU - Bono, Roberto
AU - Kovalchuk, Sofia
AU - Bosi, Alberto
AU - Di Lollo, Simonetta
AU - Di Napoli, Arianna
AU - Fratoni, Stefano
AU - Abruzzese, Elisabetta
AU - Rigacci, Luigi
AU - Bocchia, Monica
AU - Goteri, Gaia
AU - Gini, Guido
AU - Leoncini, Lorenzo
AU - Di Napoli, Arianna
AU - Fabbri, Alberto
AU - Mancuso, Salvatrice
AU - Bono, Roberto
PY - 2017
Y1 - 2017
N2 - In Hodgkin Lymphoma (HL), about 20% of patients still have relapsed/refractory disease and late toxic effects rate continue to rise with time. ‘Early FDG-PET’ and tissue macrophage infiltration (TAM) emerged as powerful prognostic predictors. The primary endpoint was to investigate the prognostic role of both early FDG-PET and TAM; the secondary endpoint was to test if early FDG-PET positivity could correlate with high TAM score.A cohort of 200 HL patients was analysed. Induction treatment plan consisted of two to six courses of ABVD and, if indicated, involved field radiation therapy. All patients repeated CT scan and FDG-PET after two cycles and after the completion of therapy. TAM in diagnostic specimens was determined by immunohistochemistry with a monoclonal antibody (anti-CD68 KP1). Overall, early FDG-PET was negative in 163 patients (81.5%) and positive in 37 patients (18.5%), showing a significant correlation with the achievement of CR (p<0.0001). After a median follow-up of 40months, progression free survival (PFS) was significantly better for PET negative patients (p<0.0001). CD68 expression was low, intermediate or high in 26 (13%), 100 (50%) and 74 (37%) cases, without difference in the distribution between responders and non-responders. PFS analysis showed no significant difference in any score group. TAM score did not show any correlation with early FDG-PET result.This study confirms that early FDG-PET has a high prognostic power, while TAM score does not seem to influence the outcome; in contrast to our original hypothesis, it does not correlate with FDG-PET assessment.
AB - In Hodgkin Lymphoma (HL), about 20% of patients still have relapsed/refractory disease and late toxic effects rate continue to rise with time. ‘Early FDG-PET’ and tissue macrophage infiltration (TAM) emerged as powerful prognostic predictors. The primary endpoint was to investigate the prognostic role of both early FDG-PET and TAM; the secondary endpoint was to test if early FDG-PET positivity could correlate with high TAM score.A cohort of 200 HL patients was analysed. Induction treatment plan consisted of two to six courses of ABVD and, if indicated, involved field radiation therapy. All patients repeated CT scan and FDG-PET after two cycles and after the completion of therapy. TAM in diagnostic specimens was determined by immunohistochemistry with a monoclonal antibody (anti-CD68 KP1). Overall, early FDG-PET was negative in 163 patients (81.5%) and positive in 37 patients (18.5%), showing a significant correlation with the achievement of CR (p<0.0001). After a median follow-up of 40months, progression free survival (PFS) was significantly better for PET negative patients (p<0.0001). CD68 expression was low, intermediate or high in 26 (13%), 100 (50%) and 74 (37%) cases, without difference in the distribution between responders and non-responders. PFS analysis showed no significant difference in any score group. TAM score did not show any correlation with early FDG-PET result.This study confirms that early FDG-PET has a high prognostic power, while TAM score does not seem to influence the outcome; in contrast to our original hypothesis, it does not correlate with FDG-PET assessment.
UR - http://hdl.handle.net/10447/215771
M3 - Article
SN - 0278-0232
VL - 35
SP - 69
EP - 78
JO - Hematological Oncology
JF - Hematological Oncology
ER -