Evaluation of posttreatment responseof hepatocellular carcinoma: comparisonof ultrasonography with second-generationultrasound contrast agent and multidetector CT

Giuseppe Caruso, Maria Franca Meloni, Antonella Campisi, Giuseppe Salvaggio

Risultato della ricerca: Articlepeer review

50 Citazioni (Scopus)

Abstract

We evaluated the ability of one-month follow-up contrast-enhanced ultrasound (CEUS) with second-generationcontrast agent in monitoring radio frequencyablation (RFA) and transcatheter arterial chemoembolization(TACE) treatments of hepatocellular carcinoma(HCC). One-hundred forty-eight HCCs were studiedusing CEUS: 110 nodules were treated with RFA [41/110RFA were performed using a pretreatment and animmediate postablation evaluation using CEUS (group1); 69/110 using only US guidance (group 2)] and 38nodules treated with TACE. For statistical analysis,McNemar test was used. Overall complete response wasobserved in 107/148 nodules (92/110 treated with RFAand 15/38 with TACE). A better rate of complete responsewas found in group 1 compared to group 2(92.7% vs. 78.3%). In RFA treatment, CEUS showed asensitivity of 83.3% and a specificity of 100% (diagnosticaccuracy of 97%) using MDCT as reference standardwith no statistical difference (p > 0.05). CEUS detectedall cases of incomplete response in HCC treated withTACE using angiography as reference standard (diagnosticaccuracy 100%).We recommend assessing residualintratumoral flow on CEUS during RFA procedure todetermine the necessity of immediate additional treatment.In case of positive CEUS results, HCC treatedwith TACE should be considered still viable.
Lingua originaleEnglish
pagine (da-a)447-453
Numero di pagine7
RivistaABDOMINAL IMAGING
Volume35
Stato di pubblicazionePublished - 2010

All Science Journal Classification (ASJC) codes

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Gastroenterology
  • Urology

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