Evaluation of chronic alcohol self-administration by a 3-bottle choice paradigm in adult male rats. Effects on behavioural reactivity, spatial learning and reference memory

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Abstract

Chronic ethanol consumption is able to modify emotional behaviour and cognition in humans.In particular, the effects exerted by alcohol may depend on doses,time and modalities of administration.In this study we investigated,in adult male rats,ethanol self-administration and preference patterns using a 3-bottle choice paradigm with water,10%ethanol solution,and white wine(10%,v/v),along a four- week period.The influence of alcohol free-access on novelty-induced explorative behaviour in the open field, and on spatial learning and reference memory in the Morris water maze was also evaluated.Our results indicate that:(i)rats show a higher preference for alcohol,in the first two weeks of the paradigm, displaying a higher consumption of 10%ethanol solution than white wine;in the last two weeks,they reduce their alcoholic preference,drinking the same moderate amounts of the two alcoholic beverages; (ii) at the fourth week of the free-access paradigm rats show a high explorative behaviour in the central squares of the open field and an improvement in spatial information processing in the new-place learning task of the Morris water maze.Inconclusion our data suggest that,interestingly,rats exposed to the free-access paradigm were able to self-regulate their alcoholic intake,and indicated that a moderate alcohol consumption was able to induce an increase in behavioural reactivity and anenhancement in spatial learning flexibility.
Lingua originaleEnglish
pagine (da-a)213-220
Numero di pagine8
RivistaBehavioural Brain Research
Volume219
Stato di pubblicazionePublished - 2011

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Self Administration
Ethanol
Alcohols
Wine
Water
Alcoholic Beverages
Automatic Data Processing
Cognition
Drinking
Learning
Spatial Learning

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience

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title = "Evaluation of chronic alcohol self-administration by a 3-bottle choice paradigm in adult male rats. Effects on behavioural reactivity, spatial learning and reference memory",
abstract = "Chronic ethanol consumption is able to modify emotional behaviour and cognition in humans.In particular, the effects exerted by alcohol may depend on doses,time and modalities of administration.In this study we investigated,in adult male rats,ethanol self-administration and preference patterns using a 3-bottle choice paradigm with water,10{\%}ethanol solution,and white wine(10{\%},v/v),along a four- week period.The influence of alcohol free-access on novelty-induced explorative behaviour in the open field, and on spatial learning and reference memory in the Morris water maze was also evaluated.Our results indicate that:(i)rats show a higher preference for alcohol,in the first two weeks of the paradigm, displaying a higher consumption of 10{\%}ethanol solution than white wine;in the last two weeks,they reduce their alcoholic preference,drinking the same moderate amounts of the two alcoholic beverages; (ii) at the fourth week of the free-access paradigm rats show a high explorative behaviour in the central squares of the open field and an improvement in spatial information processing in the new-place learning task of the Morris water maze.Inconclusion our data suggest that,interestingly,rats exposed to the free-access paradigm were able to self-regulate their alcoholic intake,and indicated that a moderate alcohol consumption was able to induce an increase in behavioural reactivity and anenhancement in spatial learning flexibility.",
keywords = "Alcohol self-administration; Free-choice paradigm; Alcoholic preference; Explorative behaviour; Spatial learning; Reference memory",
author = "Carla Cannizzaro and Fulvio Plescia and Silvana Cacace and {La Barbera}, Marco",
year = "2011",
language = "English",
volume = "219",
pages = "213--220",
journal = "Behavioural Brain Research",
issn = "0166-4328",
publisher = "Elsevier",

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TY - JOUR

T1 - Evaluation of chronic alcohol self-administration by a 3-bottle choice paradigm in adult male rats. Effects on behavioural reactivity, spatial learning and reference memory

AU - Cannizzaro, Carla

AU - Plescia, Fulvio

AU - Cacace, Silvana

AU - La Barbera, Marco

PY - 2011

Y1 - 2011

N2 - Chronic ethanol consumption is able to modify emotional behaviour and cognition in humans.In particular, the effects exerted by alcohol may depend on doses,time and modalities of administration.In this study we investigated,in adult male rats,ethanol self-administration and preference patterns using a 3-bottle choice paradigm with water,10%ethanol solution,and white wine(10%,v/v),along a four- week period.The influence of alcohol free-access on novelty-induced explorative behaviour in the open field, and on spatial learning and reference memory in the Morris water maze was also evaluated.Our results indicate that:(i)rats show a higher preference for alcohol,in the first two weeks of the paradigm, displaying a higher consumption of 10%ethanol solution than white wine;in the last two weeks,they reduce their alcoholic preference,drinking the same moderate amounts of the two alcoholic beverages; (ii) at the fourth week of the free-access paradigm rats show a high explorative behaviour in the central squares of the open field and an improvement in spatial information processing in the new-place learning task of the Morris water maze.Inconclusion our data suggest that,interestingly,rats exposed to the free-access paradigm were able to self-regulate their alcoholic intake,and indicated that a moderate alcohol consumption was able to induce an increase in behavioural reactivity and anenhancement in spatial learning flexibility.

AB - Chronic ethanol consumption is able to modify emotional behaviour and cognition in humans.In particular, the effects exerted by alcohol may depend on doses,time and modalities of administration.In this study we investigated,in adult male rats,ethanol self-administration and preference patterns using a 3-bottle choice paradigm with water,10%ethanol solution,and white wine(10%,v/v),along a four- week period.The influence of alcohol free-access on novelty-induced explorative behaviour in the open field, and on spatial learning and reference memory in the Morris water maze was also evaluated.Our results indicate that:(i)rats show a higher preference for alcohol,in the first two weeks of the paradigm, displaying a higher consumption of 10%ethanol solution than white wine;in the last two weeks,they reduce their alcoholic preference,drinking the same moderate amounts of the two alcoholic beverages; (ii) at the fourth week of the free-access paradigm rats show a high explorative behaviour in the central squares of the open field and an improvement in spatial information processing in the new-place learning task of the Morris water maze.Inconclusion our data suggest that,interestingly,rats exposed to the free-access paradigm were able to self-regulate their alcoholic intake,and indicated that a moderate alcohol consumption was able to induce an increase in behavioural reactivity and anenhancement in spatial learning flexibility.

KW - Alcohol self-administration; Free-choice paradigm; Alcoholic preference; Explorative behaviour; Spatial learning; Reference memory

UR - http://hdl.handle.net/10447/55734

M3 - Article

VL - 219

SP - 213

EP - 220

JO - Behavioural Brain Research

JF - Behavioural Brain Research

SN - 0166-4328

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