EVALUATION OF BIODEGRADABILITY ON POLYSPARTAMIDE-POLYLACTIC ACID BASED NANOPARTICLES BY CHEMICAL HYDROLYSIS STUDIES POLYMER DEGRADATION AND STABILITY

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Abstract

Here, the synthesis of two graft copolymers based on α,β-poly(N-2-hydroxyethyl)-D,L-aspartamide (PHEA) and poly(lactic acid) (PLA), the O-(2-aminoethyl)-O′-galactosyl polyethylene glycol (GAL-PEG-NH2) or the methoxypolyethylene glycol amine (H2N-PEG-OCH3) is described. Starting from the obtained PHEA-PLA-PEG-GAL and PHEA-PLA-PEG copolymers, polymeric nanoparticles were prepared by high pressure homogenization–solvent evaporation method. To demonstrate their biodegradability as a function of the matrix composition, a chemical stability study was carried out until 21 days by incubating systems in two media mimicking physiological compartments (pH 7.4 and pH 5.5). The degradability of both nanosystems was firstly confirmed by the reduction of the pH of the incubation medium. Moreover, the percentage yield of recovered nanoparticles show a gradual reduction while mean size increases as a function of incubation time. Degradation seems to be mainly attributed to the loss of water-soluble portions of PLA, and proceeds with greater speed at pH 5.5, than at pH 7.4 and as a function of matrix composition
Lingua originaleEnglish
pagine (da-a)56-67
Numero di pagine12
RivistaPolymer Degradation and Stability
Volume119
Stato di pubblicazionePublished - 2015

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biodegradability
Biodegradability
lactic acid
Polyethylene glycols
hydrolysis
Hydrolysis
Lactic acid
Polymers
degradation
Nanoparticles
Degradation
nanoparticles
acids
Acids
evaluation
polymers
glycols
copolymers
Nanosystems
Graft copolymers

All Science Journal Classification (ASJC) codes

  • Condensed Matter Physics
  • Materials Chemistry
  • Polymers and Plastics
  • Mechanics of Materials

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@article{79790c47fe934c23a028471d47faf1a9,
title = "EVALUATION OF BIODEGRADABILITY ON POLYSPARTAMIDE-POLYLACTIC ACID BASED NANOPARTICLES BY CHEMICAL HYDROLYSIS STUDIES POLYMER DEGRADATION AND STABILITY",
abstract = "Here, the synthesis of two graft copolymers based on α,β-poly(N-2-hydroxyethyl)-D,L-aspartamide (PHEA) and poly(lactic acid) (PLA), the O-(2-aminoethyl)-O′-galactosyl polyethylene glycol (GAL-PEG-NH2) or the methoxypolyethylene glycol amine (H2N-PEG-OCH3) is described. Starting from the obtained PHEA-PLA-PEG-GAL and PHEA-PLA-PEG copolymers, polymeric nanoparticles were prepared by high pressure homogenization–solvent evaporation method. To demonstrate their biodegradability as a function of the matrix composition, a chemical stability study was carried out until 21 days by incubating systems in two media mimicking physiological compartments (pH 7.4 and pH 5.5). The degradability of both nanosystems was firstly confirmed by the reduction of the pH of the incubation medium. Moreover, the percentage yield of recovered nanoparticles show a gradual reduction while mean size increases as a function of incubation time. Degradation seems to be mainly attributed to the loss of water-soluble portions of PLA, and proceeds with greater speed at pH 5.5, than at pH 7.4 and as a function of matrix composition",
author = "Gaetano Giammona and Gennara Cavallaro and Craparo, {Emanuela Fabiola} and Barbara Porsio and Bond{\`i}, {Maria Luisa}",
year = "2015",
language = "English",
volume = "119",
pages = "56--67",
journal = "Polymer Degradation and Stability",
issn = "0141-3910",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - EVALUATION OF BIODEGRADABILITY ON POLYSPARTAMIDE-POLYLACTIC ACID BASED NANOPARTICLES BY CHEMICAL HYDROLYSIS STUDIES POLYMER DEGRADATION AND STABILITY

AU - Giammona, Gaetano

AU - Cavallaro, Gennara

AU - Craparo, Emanuela Fabiola

AU - Porsio, Barbara

AU - Bondì, Maria Luisa

PY - 2015

Y1 - 2015

N2 - Here, the synthesis of two graft copolymers based on α,β-poly(N-2-hydroxyethyl)-D,L-aspartamide (PHEA) and poly(lactic acid) (PLA), the O-(2-aminoethyl)-O′-galactosyl polyethylene glycol (GAL-PEG-NH2) or the methoxypolyethylene glycol amine (H2N-PEG-OCH3) is described. Starting from the obtained PHEA-PLA-PEG-GAL and PHEA-PLA-PEG copolymers, polymeric nanoparticles were prepared by high pressure homogenization–solvent evaporation method. To demonstrate their biodegradability as a function of the matrix composition, a chemical stability study was carried out until 21 days by incubating systems in two media mimicking physiological compartments (pH 7.4 and pH 5.5). The degradability of both nanosystems was firstly confirmed by the reduction of the pH of the incubation medium. Moreover, the percentage yield of recovered nanoparticles show a gradual reduction while mean size increases as a function of incubation time. Degradation seems to be mainly attributed to the loss of water-soluble portions of PLA, and proceeds with greater speed at pH 5.5, than at pH 7.4 and as a function of matrix composition

AB - Here, the synthesis of two graft copolymers based on α,β-poly(N-2-hydroxyethyl)-D,L-aspartamide (PHEA) and poly(lactic acid) (PLA), the O-(2-aminoethyl)-O′-galactosyl polyethylene glycol (GAL-PEG-NH2) or the methoxypolyethylene glycol amine (H2N-PEG-OCH3) is described. Starting from the obtained PHEA-PLA-PEG-GAL and PHEA-PLA-PEG copolymers, polymeric nanoparticles were prepared by high pressure homogenization–solvent evaporation method. To demonstrate their biodegradability as a function of the matrix composition, a chemical stability study was carried out until 21 days by incubating systems in two media mimicking physiological compartments (pH 7.4 and pH 5.5). The degradability of both nanosystems was firstly confirmed by the reduction of the pH of the incubation medium. Moreover, the percentage yield of recovered nanoparticles show a gradual reduction while mean size increases as a function of incubation time. Degradation seems to be mainly attributed to the loss of water-soluble portions of PLA, and proceeds with greater speed at pH 5.5, than at pH 7.4 and as a function of matrix composition

UR - http://hdl.handle.net/10447/140812

UR - http://10.1016/j.polymdegradstab.2015.05.003

M3 - Article

VL - 119

SP - 56

EP - 67

JO - Polymer Degradation and Stability

JF - Polymer Degradation and Stability

SN - 0141-3910

ER -