Evaluation of [1,2]oxazolo[5,4-e]isoindoles in lymphoma cells

Virginia Spano', Alessandra Montalbano, Maria Valeria Raimondi, Paola Barraja, Marilia Barreca, Ernest Hamel, Francesco Bertoni, Gaudio, Bai, Alcaro

Risultato della ricerca: Posterpeer review

Abstract

Anti-tubulin agents are important chemotherapeutics.Combretastatin A-4 (CA-4) emerged as lead compound for the design ofnew tubulin-binding agents. Its analogues 4,5-diarylisoxazoles, containingthe [1,2]oxazole ring as linker of two aryl moieties, displayed higher antitubulinactivity than CA-4. [1,2]oxazolo[5,4-e]isoindoles also gave excellentresults reducing cell growth of NCI-60 tumor cell lines and diffuse malignantperitoneal mesothelioma (DMPM) cells. Selected derivatives showed in vivoantitumor activity at well-tolerated doses in a DMPM xenograft model.[1,2]oxazolo[5,4-e]isoindoles were screened in four lymphoma histotypes:germinal center B-cell and activated diffuse large B cell lymphoma, marginalzone lymphoma and mantle cell lymphoma.
Lingua originaleEnglish
PagineS35-S36
Numero di pagine2
Stato di pubblicazionePublished - 2020

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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