Eutopic endometrium from women with endometriosis does not exhibit neurotrophic properties

Vito Chiantera, Maria Luisa Barcena De Arellano, Giuseppe F. Vercellino, Magdalena Staube, Matthias Blöchle, Frank Sacher, Julia Arnold, Achim Schneider, Sylvia Mechsner, Vito Chiantera, Julia Bartley

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Abstract

The role of neurotrophins in eutopic endometrium from endometriosis-patients was investigated in a prospective study using immunofluorescence-staining, Western blot and a neuronal growth assay. The nerve growth factor is expressed in primary endometrial cell culture from women with and without endometriosis. Western blot analysis of endometrial biopsies or uterine fluid from patients with and without endometriosis shows no difference in the neurotrophin expression. We could not find a difference between patients with and without endometriosis with regards to the neurite outgrowth of sensory ganglia when treated with conditioned cultured medium or uterine fluid. This result refutes the assumed neurotrophic properties of eutopic endometrium of patients with endometriosis. © 2012 Elsevier B.V.
Lingua originaleEnglish
pagine (da-a)49-55
Numero di pagine7
RivistaJournal of Neuroimmunology
Volume249
Stato di pubblicazionePublished - 2012

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All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

Cita questo

Chiantera, V., Barcena De Arellano, M. L., Vercellino, G. F., Staube, M., Blöchle, M., Sacher, F., Arnold, J., Schneider, A., Mechsner, S., Chiantera, V., & Bartley, J. (2012). Eutopic endometrium from women with endometriosis does not exhibit neurotrophic properties. Journal of Neuroimmunology, 249, 49-55.