Estrogen metabolism modulates bone density in men

Giovam Battista Rini, Nicola Napoli, G. Battista Rini, Salvatore Bucchieri, Reina Armamento-Villareal, Faccio, Nicola Napoli, Salvatore Bucchieri

    Risultato della ricerca: Article

    20 Citazioni (Scopus)

    Abstract

    Estrogen is a critical hormone for bone homeostasis in men, but no information is available on the role of estrogen metabolism among men. The aim of this study was to evaluate the effect of estrogen hydroxylation on male bone mineral density (BMD). Participants consisted of 61 healthy Caucasian males (mean age 66.6 +/- 1.0 years). Urinary estrogen metabolites were measured by enzyme-linked immunosorbent assay, serum estradiol by ultrasensitive radioimmunoassay, sex hormone binding globulin by radioimmunoassay, and BMD of the lumbar spine and the proximal femur by dual-energy X-ray absorptiometry. Active estrogen metabolites, 16alpha-hydroxyestrone (16alphaOHE(1)) and estriol (E(3)), positively correlated with adjusted BMD in all regions of the proximal femur (all P < 0.05) but not at the lumbar spine, and those in the highest tertile of urinary 16alphaOHE(1 )had the highest BMD. Free estradiol index (FEI) also positively correlated with BMD of the total hip, femoral neck, and intertrochanter (all P < 0.05), while there was no correlation between BMD with inactive metabolites (2-hydroxyestrone and 2-methoxyestrone) and serum testosterone. Multiple regression analysis showed 16alphaOHE(1), FEI, and body mass index are important independent predictors of BMD in all regions of the proximal femur. Estrogen metabolism may modulate BMD in men. Increased urinary 16alphaOHE(1) and E(3) levels are associated with high BMD at the proximal femur, and 16alphaOHE(1) appears to be a major determinant of BMD among the metabolites evaluated.
    Lingua originaleEnglish
    pagine (da-a)227-232
    RivistaDefault journal
    Volume80(4)
    Stato di pubblicazionePublished - 2007

    Fingerprint

    Bone Density
    Estrogens
    Femur
    Estradiol
    Radioimmunoassay
    Spine
    Hydroxyestrones
    Sex Hormone-Binding Globulin
    Estriol
    Femur Neck
    Photon Absorptiometry
    Hydroxylation
    Serum
    Testosterone
    Hip
    Body Mass Index
    Homeostasis
    Enzyme-Linked Immunosorbent Assay
    Regression Analysis
    Hormones

    All Science Journal Classification (ASJC) codes

    • Endocrinology, Diabetes and Metabolism
    • Orthopedics and Sports Medicine
    • Endocrinology

    Cita questo

    Rini, G. B., Napoli, N., Rini, G. B., Bucchieri, S., Armamento-Villareal, R., Faccio, ... Bucchieri, S. (2007). Estrogen metabolism modulates bone density in men. Default journal, 80(4), 227-232.

    Estrogen metabolism modulates bone density in men. / Rini, Giovam Battista; Napoli, Nicola; Rini, G. Battista; Bucchieri, Salvatore; Armamento-Villareal, Reina; Faccio; Napoli, Nicola; Bucchieri, Salvatore.

    In: Default journal, Vol. 80(4), 2007, pag. 227-232.

    Risultato della ricerca: Article

    Rini, GB, Napoli, N, Rini, GB, Bucchieri, S, Armamento-Villareal, R, Faccio, Napoli, N & Bucchieri, S 2007, 'Estrogen metabolism modulates bone density in men', Default journal, vol. 80(4), pagg. 227-232.
    Rini GB, Napoli N, Rini GB, Bucchieri S, Armamento-Villareal R, Faccio e altri. Estrogen metabolism modulates bone density in men. Default journal. 2007;80(4):227-232.
    Rini, Giovam Battista ; Napoli, Nicola ; Rini, G. Battista ; Bucchieri, Salvatore ; Armamento-Villareal, Reina ; Faccio ; Napoli, Nicola ; Bucchieri, Salvatore. / Estrogen metabolism modulates bone density in men. In: Default journal. 2007 ; Vol. 80(4). pagg. 227-232.
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    abstract = "Estrogen is a critical hormone for bone homeostasis in men, but no information is available on the role of estrogen metabolism among men. The aim of this study was to evaluate the effect of estrogen hydroxylation on male bone mineral density (BMD). Participants consisted of 61 healthy Caucasian males (mean age 66.6 +/- 1.0 years). Urinary estrogen metabolites were measured by enzyme-linked immunosorbent assay, serum estradiol by ultrasensitive radioimmunoassay, sex hormone binding globulin by radioimmunoassay, and BMD of the lumbar spine and the proximal femur by dual-energy X-ray absorptiometry. Active estrogen metabolites, 16alpha-hydroxyestrone (16alphaOHE(1)) and estriol (E(3)), positively correlated with adjusted BMD in all regions of the proximal femur (all P < 0.05) but not at the lumbar spine, and those in the highest tertile of urinary 16alphaOHE(1 )had the highest BMD. Free estradiol index (FEI) also positively correlated with BMD of the total hip, femoral neck, and intertrochanter (all P < 0.05), while there was no correlation between BMD with inactive metabolites (2-hydroxyestrone and 2-methoxyestrone) and serum testosterone. Multiple regression analysis showed 16alphaOHE(1), FEI, and body mass index are important independent predictors of BMD in all regions of the proximal femur. Estrogen metabolism may modulate BMD in men. Increased urinary 16alphaOHE(1) and E(3) levels are associated with high BMD at the proximal femur, and 16alphaOHE(1) appears to be a major determinant of BMD among the metabolites evaluated.",
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    AU - Rini, Giovam Battista

    AU - Napoli, Nicola

    AU - Rini, G. Battista

    AU - Bucchieri, Salvatore

    AU - Armamento-Villareal, Reina

    AU - Faccio, null

    AU - Napoli, Nicola

    AU - Bucchieri, Salvatore

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    N2 - Estrogen is a critical hormone for bone homeostasis in men, but no information is available on the role of estrogen metabolism among men. The aim of this study was to evaluate the effect of estrogen hydroxylation on male bone mineral density (BMD). Participants consisted of 61 healthy Caucasian males (mean age 66.6 +/- 1.0 years). Urinary estrogen metabolites were measured by enzyme-linked immunosorbent assay, serum estradiol by ultrasensitive radioimmunoassay, sex hormone binding globulin by radioimmunoassay, and BMD of the lumbar spine and the proximal femur by dual-energy X-ray absorptiometry. Active estrogen metabolites, 16alpha-hydroxyestrone (16alphaOHE(1)) and estriol (E(3)), positively correlated with adjusted BMD in all regions of the proximal femur (all P < 0.05) but not at the lumbar spine, and those in the highest tertile of urinary 16alphaOHE(1 )had the highest BMD. Free estradiol index (FEI) also positively correlated with BMD of the total hip, femoral neck, and intertrochanter (all P < 0.05), while there was no correlation between BMD with inactive metabolites (2-hydroxyestrone and 2-methoxyestrone) and serum testosterone. Multiple regression analysis showed 16alphaOHE(1), FEI, and body mass index are important independent predictors of BMD in all regions of the proximal femur. Estrogen metabolism may modulate BMD in men. Increased urinary 16alphaOHE(1) and E(3) levels are associated with high BMD at the proximal femur, and 16alphaOHE(1) appears to be a major determinant of BMD among the metabolites evaluated.

    AB - Estrogen is a critical hormone for bone homeostasis in men, but no information is available on the role of estrogen metabolism among men. The aim of this study was to evaluate the effect of estrogen hydroxylation on male bone mineral density (BMD). Participants consisted of 61 healthy Caucasian males (mean age 66.6 +/- 1.0 years). Urinary estrogen metabolites were measured by enzyme-linked immunosorbent assay, serum estradiol by ultrasensitive radioimmunoassay, sex hormone binding globulin by radioimmunoassay, and BMD of the lumbar spine and the proximal femur by dual-energy X-ray absorptiometry. Active estrogen metabolites, 16alpha-hydroxyestrone (16alphaOHE(1)) and estriol (E(3)), positively correlated with adjusted BMD in all regions of the proximal femur (all P < 0.05) but not at the lumbar spine, and those in the highest tertile of urinary 16alphaOHE(1 )had the highest BMD. Free estradiol index (FEI) also positively correlated with BMD of the total hip, femoral neck, and intertrochanter (all P < 0.05), while there was no correlation between BMD with inactive metabolites (2-hydroxyestrone and 2-methoxyestrone) and serum testosterone. Multiple regression analysis showed 16alphaOHE(1), FEI, and body mass index are important independent predictors of BMD in all regions of the proximal femur. Estrogen metabolism may modulate BMD in men. Increased urinary 16alphaOHE(1) and E(3) levels are associated with high BMD at the proximal femur, and 16alphaOHE(1) appears to be a major determinant of BMD among the metabolites evaluated.

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