Objective. Ovarian cancer comprises several histological groups with widely differing levels of survival. Weaimed to explore international variation in survival for each group to help interpret international differences insurvival from all ovarian cancers combined. We also examined differences in stage-specific survival.Methods. The CONCORD programme is the largest population-based study of global trends in cancer survival,including data from 60 countries for 695,932 women (aged 15–99 years) diagnosed with ovarian cancer during1995–2009. We defined six histological groups: type I epithelial, type II epithelial, germ cell, sex cord-stromal,other specific non-epithelial and non-specific morphology, and estimated age-standardised 5-year net survivalfor each country by histological group. We also analysed data from67 cancer registries for 233,659 women diagnosedfrom 2001 to 2009, for whom information on stage at diagnosis was available. We estimated agestandardised5-year net survival by stage at diagnosis (localised or advanced).Results. Survival fromtype I epithelial ovarian tumours for women diagnosed during 2005–09 ranged from40to 70%. Survival from type II epithelial tumours was much lower (20–45%). Survival fromgermcell tumours washigher than that of type II epithelial tumours, but also varied widely between countries. Survival for sex-cordstromal tumours was higher than for the five other groups. Survival from localised tumours was much higherthan for advanced disease (80% vs. 30%).Conclusions. There is wide variation in survival between histological groups, and stage at diagnosis remains animportant factor in ovarian cancer survival. International comparisons of ovarian cancer survival should incorporatehistology.
|Numero di pagine||1|
|Stato di pubblicazione||Published - 2017|
All Science Journal Classification (ASJC) codes
- Obstetrics and Gynaecology