Objective. Ovarian cancers comprise several histologically distinct tumour groups with widely different prognosis.We aimed to describe the worldwide distribution of ovarian cancer histology and to understand what rolethis may play in international variation in survival.Methods. The CONCORD programme is the largest population-based study of global trends in cancer survival.Data on 681,759 women diagnosed during 1995–2009 with cancer of the ovary, fallopian tube, peritoneum andretroperitonum in 51 countries were included.We categorised ovarian tumours into six histological groups, andexplored the worldwide distribution of histology.Results. During 2005–2009, type II epithelial tumours were the most common. The proportion was muchhigher in Oceania (73.1%), North America (73.0%) and Europe (72.6%) than in Central and South America(65.7%) and Asia (56.1%). By contrast, type I epithelial tumours were more common in Asia (32.5%), comparedwith only 19.4% in North America. From 1995 to 2009, the proportion of type II epithelial tumours increasedfrom 68.6% to 71.1%, while the proportion of type I epithelial tumours fell from 23.8% to 21.2%. The proportionsof germ cell tumours, sex cord-stromal tumours, other specific non-epithelial tumours and tumours of non-specific morphology all remained stable over time.Conclusions. The distribution of ovarian cancer histology varieswidely worldwide. Type I epithelial, germcelland sex cord-stromal tumours are generally associated with higher survival than type II tumours, so the proportion of these tumours may influence survival estimates for all ovarian cancers combined. The distribution of histological groups should be considered when comparing survival between countries and regions.
|Numero di pagine||1|
|Stato di pubblicazione||Published - 2017|
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