Equilibrium, structural and biological activity studies on organotin(IV)n+ complexes

Claudia Pellerito, Tiziana Fiore, Michelangelo Scopelliti, Lorenzo Pellerito, Eniko Nagy, Attila Szorcsik, László Nagy

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Abstract

Organotin(IV) compounds are characterized by the presence of at least one covalent C–Sn bond. The compounds contain tetravalent {Sn} centers and are classified as mono-, di-, tri-, and tetraorganotin(IV), depending on the number of alkyl (R) or aryl (Ar) moieties bound. The anions are usually Cl, F, O2, OH,–COO, or –S. It seems that the nature of the anionic group has only secondary importance in biological activity.The rapid rise in the industrial (catalyst in PVC and foam production), agricultural(fungicides and acaricides), and biological applications (wood, stone, and glass preservatives) of organotin(IV) compounds during the last few decades has ledto their accumulation in the environment and, consequently, in biological systems.It is well known that organotin(IV) compounds display strong biologicalactivity. Most organotin(IV) compounds are generally very toxic, even at lowconcentration. The biological activity is essentially determined by the number andnature of the organic groups bound to the central {Sn} atom. The [R3Sn(IV)]+ and[Ar3Sn(IV)]+ derivatives exert powerful toxic action on the central nervoussystem. Within the series of [R3Sn(IV)]+ compounds, the lower homologs (Me, Et)are the most toxic when administrated orally, and the toxicity decreasesprogressively from propyl (Pr) to octyl (Oc), the latter being not toxic at alltowards humans.
Lingua originaleEnglish
Titolo della pubblicazione ospiteAdvances in Organometallic Chemistry
Pagine353-447
Numero di pagine95
Stato di pubblicazionePublished - 2008

Serie di pubblicazioni

NomeAdvances in Organometallic Chemistry

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All Science Journal Classification (ASJC) codes

  • Organic Chemistry

Cita questo

Pellerito, C., Fiore, T., Scopelliti, M., Pellerito, L., Nagy, E., Szorcsik, A., & Nagy, L. (2008). Equilibrium, structural and biological activity studies on organotin(IV)n+ complexes. In Advances in Organometallic Chemistry (pagg. 353-447). (Advances in Organometallic Chemistry).