Epidemiology and clonality of carbapenem-resistant Acinetobacter baumannii from an intensive care unit in Palermo, Italy.

Celestino Bonura, Teresa Maria Assunta Fasciana, Caterina Mammina, Cinzia Cala', Romano Tetamo, Daniela Maria Palma, Andrea Neville Cracchiolo, Maria Antonietta Saporito, Maria Stella Verde, Andrea Neville Cracchiolo, Andrea Neville Cracchiolo, Concetta Sodano, Aurora Aleo

Risultato della ricerca: Articlepeer review

17 Citazioni (Scopus)

Abstract

BACKGROUND: Multidrug-resistant Acinetobacter baumannii, initially considered as having a poor clinical relevance, is frequently isolated from infection cases in intensive care units. We describe the epidemiology of carbapenem resistant A. baumannii (CRAB) in a general ICU in Palermo, Italy, from October 2010 to March 2011.FINDINGS: 58 of 61 isolates exhibited MICs for meropenem or imipenem ≥16 mg/L. Forty-nine carried blaOXA-23 and two blaOXA-58 genes.Five subtype clusters were detected by rep-PCR. Clusters D and E included 10 isolates that tested negative for the carbapenem resistance genes. MLST attributed all isolates, but two, with sequence type (ST)2, whereas the two remaining isolates with ST78.The respiratory tract was the most common site of infection (26 out of 36 cases. 72.2%). A high infection related mortality rate was observed (18 out of 35 patients, 51.4%). Nineteen patients tested positive for other multidrug resistant organisms in addition to CRAB. In eight cases isolates belonging to distinct subtype clusters and/or with distinct carbapenemase profiles were identified.CONCLUSIONS: Carbapenem resistance was prominently driven by the dissemination of CRAB isolates belonging to ST2, carrying the carbapenemase gene blaOXA-23. The colonization/infection of some patients by multiple strains is suggestive of an endemic circulation of CRAB.
Lingua originaleEnglish
pagine (da-a)1-8
Numero di pagine8
RivistaBMC Research Notes
Volume5
Stato di pubblicazionePublished - 2012

All Science Journal Classification (ASJC) codes

  • ???subjectarea.asjc.1300.1300???

Fingerprint Entra nei temi di ricerca di 'Epidemiology and clonality of carbapenem-resistant Acinetobacter baumannii from an intensive care unit in Palermo, Italy.'. Insieme formano una fingerprint unica.

Cita questo