Enuresis subtypes based on nocturnal hypercalciuria: A multicenter study

Marcello Cimador, Lorenzo Cresta, Gabriella Aceto, Marcello Cimador, Rosa Penza, Maria Laura Chiozza, Paolo Caione, Maria Susanna Coccioli, Fabrizio Palumbo

Risultato della ricerca: Article

42 Citazioni (Scopus)

Abstract

Purpose: Desmopressin may not be effective for nocturnal enuresis associated with polyuria and hypercalciuria. Nighttime hypercalciuria in an enuretic population from 5 centers and its correlation with nighttime polyuria were verified. Materials and Methods: A total of 450 enuretic patients (278 males, 172 females, mean age 9.7 years) were evaluated with 72-hour micturition charts, urinalysis, serum creatinine and osmolarity, diurnal and nocturnal electrolytes with fractional Na+ and K+ urinary excretion, and nocturnal (4 a.m.) plasma vasopressin. Creatinine electrolytes and osmolarity were measured in daytime (8 a.m. to 8 p.m.) and nighttime (8 p.m. to 8 a.m.) urine volumes. Patients were divided into group 1 with nocturnal polyuria and group 2 without nocturnal polyuria. Hypercalciuria was defined as urinary calcium-to-urinary creatinine ratio greater than 0.21. Statistic evaluation was performed using chi-square, Pearson correlation and ANOVA tests. Results: Nighttime polyuria was demonstrated in 292 bedwetters (65% group 1). Nocturnal hypercalciuria was present in 179 of the 450 children (39.7%), including 125 in group 1 (42.8%) and 54 in group 2 (34.2%), which was statistically significant (chi-square p = 0.008, Pearson correlation test r = 0.157). Daytime calciuria was not statistically modified in either group (group 1 p = 0.054, group 2 p = 0.56). Adrenocorticotropic hormone (ADH) was normal in 18.5% and low in 81.5% of enuretics with nocturnal hypercalciuria. ADH levels and nocturnal hypercalciuria significantly correlated (p = 0.003, r = 0.148). Conversely, the group 2 patients had normal ADH levels. Conclusions: Nocturnal hypercalciuria has a pivotal role in nocturnal enuresis, as it is significantly associated with low ADH levels and nocturnal polyuria. A new classification of nocturnal enuresis subtypes based on nighttime calciuria levels is mandatory to address treatment properly.
Lingua originaleEnglish
pagine (da-a)1670-1673
Numero di pagine4
RivistaTHE JOURNAL OF UROLOGY
Volume170
Stato di pubblicazionePublished - 2003

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Enuresis
Hypercalciuria
Polyuria
Multicenter Studies
Nocturnal Enuresis
Adrenocorticotropic Hormone
Creatinine
Osmolar Concentration
Electrolytes
Deamino Arginine Vasopressin
Urinalysis
Urination
Vasopressins
Analysis of Variance
Urine
Calcium
Serum
Population

All Science Journal Classification (ASJC) codes

  • Urology

Cita questo

Cimador, M., Cresta, L., Aceto, G., Cimador, M., Penza, R., Chiozza, M. L., ... Palumbo, F. (2003). Enuresis subtypes based on nocturnal hypercalciuria: A multicenter study. THE JOURNAL OF UROLOGY, 170, 1670-1673.

Enuresis subtypes based on nocturnal hypercalciuria: A multicenter study. / Cimador, Marcello; Cresta, Lorenzo; Aceto, Gabriella; Cimador, Marcello; Penza, Rosa; Chiozza, Maria Laura; Caione, Paolo; Coccioli, Maria Susanna; Palumbo, Fabrizio.

In: THE JOURNAL OF UROLOGY, Vol. 170, 2003, pag. 1670-1673.

Risultato della ricerca: Article

Cimador, M, Cresta, L, Aceto, G, Cimador, M, Penza, R, Chiozza, ML, Caione, P, Coccioli, MS & Palumbo, F 2003, 'Enuresis subtypes based on nocturnal hypercalciuria: A multicenter study', THE JOURNAL OF UROLOGY, vol. 170, pagg. 1670-1673.
Cimador M, Cresta L, Aceto G, Cimador M, Penza R, Chiozza ML e altri. Enuresis subtypes based on nocturnal hypercalciuria: A multicenter study. THE JOURNAL OF UROLOGY. 2003;170:1670-1673.
Cimador, Marcello ; Cresta, Lorenzo ; Aceto, Gabriella ; Cimador, Marcello ; Penza, Rosa ; Chiozza, Maria Laura ; Caione, Paolo ; Coccioli, Maria Susanna ; Palumbo, Fabrizio. / Enuresis subtypes based on nocturnal hypercalciuria: A multicenter study. In: THE JOURNAL OF UROLOGY. 2003 ; Vol. 170. pagg. 1670-1673.
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title = "Enuresis subtypes based on nocturnal hypercalciuria: A multicenter study",
abstract = "Purpose: Desmopressin may not be effective for nocturnal enuresis associated with polyuria and hypercalciuria. Nighttime hypercalciuria in an enuretic population from 5 centers and its correlation with nighttime polyuria were verified. Materials and Methods: A total of 450 enuretic patients (278 males, 172 females, mean age 9.7 years) were evaluated with 72-hour micturition charts, urinalysis, serum creatinine and osmolarity, diurnal and nocturnal electrolytes with fractional Na+ and K+ urinary excretion, and nocturnal (4 a.m.) plasma vasopressin. Creatinine electrolytes and osmolarity were measured in daytime (8 a.m. to 8 p.m.) and nighttime (8 p.m. to 8 a.m.) urine volumes. Patients were divided into group 1 with nocturnal polyuria and group 2 without nocturnal polyuria. Hypercalciuria was defined as urinary calcium-to-urinary creatinine ratio greater than 0.21. Statistic evaluation was performed using chi-square, Pearson correlation and ANOVA tests. Results: Nighttime polyuria was demonstrated in 292 bedwetters (65{\%} group 1). Nocturnal hypercalciuria was present in 179 of the 450 children (39.7{\%}), including 125 in group 1 (42.8{\%}) and 54 in group 2 (34.2{\%}), which was statistically significant (chi-square p = 0.008, Pearson correlation test r = 0.157). Daytime calciuria was not statistically modified in either group (group 1 p = 0.054, group 2 p = 0.56). Adrenocorticotropic hormone (ADH) was normal in 18.5{\%} and low in 81.5{\%} of enuretics with nocturnal hypercalciuria. ADH levels and nocturnal hypercalciuria significantly correlated (p = 0.003, r = 0.148). Conversely, the group 2 patients had normal ADH levels. Conclusions: Nocturnal hypercalciuria has a pivotal role in nocturnal enuresis, as it is significantly associated with low ADH levels and nocturnal polyuria. A new classification of nocturnal enuresis subtypes based on nighttime calciuria levels is mandatory to address treatment properly.",
author = "Marcello Cimador and Lorenzo Cresta and Gabriella Aceto and Marcello Cimador and Rosa Penza and Chiozza, {Maria Laura} and Paolo Caione and Coccioli, {Maria Susanna} and Fabrizio Palumbo",
year = "2003",
language = "English",
volume = "170",
pages = "1670--1673",
journal = "Journal of Urology",
issn = "0022-5347",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Enuresis subtypes based on nocturnal hypercalciuria: A multicenter study

AU - Cimador, Marcello

AU - Cresta, Lorenzo

AU - Aceto, Gabriella

AU - Cimador, Marcello

AU - Penza, Rosa

AU - Chiozza, Maria Laura

AU - Caione, Paolo

AU - Coccioli, Maria Susanna

AU - Palumbo, Fabrizio

PY - 2003

Y1 - 2003

N2 - Purpose: Desmopressin may not be effective for nocturnal enuresis associated with polyuria and hypercalciuria. Nighttime hypercalciuria in an enuretic population from 5 centers and its correlation with nighttime polyuria were verified. Materials and Methods: A total of 450 enuretic patients (278 males, 172 females, mean age 9.7 years) were evaluated with 72-hour micturition charts, urinalysis, serum creatinine and osmolarity, diurnal and nocturnal electrolytes with fractional Na+ and K+ urinary excretion, and nocturnal (4 a.m.) plasma vasopressin. Creatinine electrolytes and osmolarity were measured in daytime (8 a.m. to 8 p.m.) and nighttime (8 p.m. to 8 a.m.) urine volumes. Patients were divided into group 1 with nocturnal polyuria and group 2 without nocturnal polyuria. Hypercalciuria was defined as urinary calcium-to-urinary creatinine ratio greater than 0.21. Statistic evaluation was performed using chi-square, Pearson correlation and ANOVA tests. Results: Nighttime polyuria was demonstrated in 292 bedwetters (65% group 1). Nocturnal hypercalciuria was present in 179 of the 450 children (39.7%), including 125 in group 1 (42.8%) and 54 in group 2 (34.2%), which was statistically significant (chi-square p = 0.008, Pearson correlation test r = 0.157). Daytime calciuria was not statistically modified in either group (group 1 p = 0.054, group 2 p = 0.56). Adrenocorticotropic hormone (ADH) was normal in 18.5% and low in 81.5% of enuretics with nocturnal hypercalciuria. ADH levels and nocturnal hypercalciuria significantly correlated (p = 0.003, r = 0.148). Conversely, the group 2 patients had normal ADH levels. Conclusions: Nocturnal hypercalciuria has a pivotal role in nocturnal enuresis, as it is significantly associated with low ADH levels and nocturnal polyuria. A new classification of nocturnal enuresis subtypes based on nighttime calciuria levels is mandatory to address treatment properly.

AB - Purpose: Desmopressin may not be effective for nocturnal enuresis associated with polyuria and hypercalciuria. Nighttime hypercalciuria in an enuretic population from 5 centers and its correlation with nighttime polyuria were verified. Materials and Methods: A total of 450 enuretic patients (278 males, 172 females, mean age 9.7 years) were evaluated with 72-hour micturition charts, urinalysis, serum creatinine and osmolarity, diurnal and nocturnal electrolytes with fractional Na+ and K+ urinary excretion, and nocturnal (4 a.m.) plasma vasopressin. Creatinine electrolytes and osmolarity were measured in daytime (8 a.m. to 8 p.m.) and nighttime (8 p.m. to 8 a.m.) urine volumes. Patients were divided into group 1 with nocturnal polyuria and group 2 without nocturnal polyuria. Hypercalciuria was defined as urinary calcium-to-urinary creatinine ratio greater than 0.21. Statistic evaluation was performed using chi-square, Pearson correlation and ANOVA tests. Results: Nighttime polyuria was demonstrated in 292 bedwetters (65% group 1). Nocturnal hypercalciuria was present in 179 of the 450 children (39.7%), including 125 in group 1 (42.8%) and 54 in group 2 (34.2%), which was statistically significant (chi-square p = 0.008, Pearson correlation test r = 0.157). Daytime calciuria was not statistically modified in either group (group 1 p = 0.054, group 2 p = 0.56). Adrenocorticotropic hormone (ADH) was normal in 18.5% and low in 81.5% of enuretics with nocturnal hypercalciuria. ADH levels and nocturnal hypercalciuria significantly correlated (p = 0.003, r = 0.148). Conversely, the group 2 patients had normal ADH levels. Conclusions: Nocturnal hypercalciuria has a pivotal role in nocturnal enuresis, as it is significantly associated with low ADH levels and nocturnal polyuria. A new classification of nocturnal enuresis subtypes based on nighttime calciuria levels is mandatory to address treatment properly.

UR - http://hdl.handle.net/10447/197164

M3 - Article

VL - 170

SP - 1670

EP - 1673

JO - Journal of Urology

JF - Journal of Urology

SN - 0022-5347

ER -