Enhanced tonic GABAA inhibition in typical absence epilepsy

Giuseppe Di Giovanni, Gergely Orban, Magor L. Lrincz, Sarah J. Fyson, Magor L. Lrincz, Gergely Orbán, Giuseppe Di Giovanni, Vincenzo Crunelli, Timothy M. Gould, David W. Cope, David A. Carter, Adam C. Errington

    Risultato della ricerca: Articlepeer review

    266 Citazioni (Scopus)

    Abstract

    The cellular mechanisms underlying typical absence seizures, which characterize various idiopathic generalized epilepsies, are not fully understood, but impaired gamma-aminobutyric acid (GABA)-ergic inhibition remains an attractive hypothesis. In contrast, we show here that extrasynaptic GABA(A) receptor-dependent 'tonic' inhibition is increased in thalamocortical neurons from diverse genetic and pharmacological models of absence seizures. Increased tonic inhibition is due to compromised GABA uptake by the GABA transporter GAT-1 in the genetic models tested, and GAT-1 is crucial in governing seizure genesis. Extrasynaptic GABA(A) receptors are a requirement for seizures in two of the best characterized models of absence epilepsy, and the selective activation of thalamic extrasynaptic GABA(A) receptors is sufficient to elicit both electrographic and behavioral correlates of seizures in normal rats. These results identify an apparently common cellular pathology in typical absence seizures that may have epileptogenic importance and highlight potential therapeutic targets for the treatment of absence epilepsy.
    Lingua originaleEnglish
    pagine (da-a)1392-1398
    Numero di pagine7
    RivistaNature Medicine
    Volume15
    Stato di pubblicazionePublished - 2009

    All Science Journal Classification (ASJC) codes

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