Engineering of Nanofibrous Amorphous and Crystalline Solid Dispersions for Oral Drug Delivery

Keating, A.; De Fátima Pina, M.; Raimi-Abraham, B.

Risultato della ricerca: Article

Abstract

Poor aqueous solubility (<0.1 mg/mL) affects a significant number of drugs currently on the market or under development. Several formulation strategies including salt formation, particle size reduction, and solid dispersion approaches have been employed with varied success. In this review, we focus primarily on the emerging trends in the generation of amorphous and micro/nano-crystalline solid dispersions using electrospinning to improve the dissolution rate and in turn the bioavailability of poorly water-soluble drugs. Electrospinning is a simple but versatile process that utilizes electrostatic forces to generate polymeric fibers and has been used for over 100 years to generate synthetic fibers. We discuss the various electrospinning studies and spinneret types that have been used to generate amorphous and crystalline solid dispersions.
Lingua originaleEnglish
pagine (da-a)7-
Numero di pagine10
RivistaPharmaceutics
Volume11
Stato di pubblicazionePublished - 2018

Cita questo

Keating, A.; De Fátima Pina, M.; Raimi-Abraham, B. (2018). Engineering of Nanofibrous Amorphous and Crystalline Solid Dispersions for Oral Drug Delivery. Pharmaceutics, 11, 7-.

Engineering of Nanofibrous Amorphous and Crystalline Solid Dispersions for Oral Drug Delivery. / Keating, A.; De Fátima Pina, M.; Raimi-Abraham, B.

In: Pharmaceutics, Vol. 11, 2018, pag. 7-.

Risultato della ricerca: Article

Keating, A.; De Fátima Pina, M.; Raimi-Abraham, B. 2018, 'Engineering of Nanofibrous Amorphous and Crystalline Solid Dispersions for Oral Drug Delivery', Pharmaceutics, vol. 11, pagg. 7-.
Keating, A.; De Fátima Pina, M.; Raimi-Abraham, B. / Engineering of Nanofibrous Amorphous and Crystalline Solid Dispersions for Oral Drug Delivery. In: Pharmaceutics. 2018 ; Vol. 11. pagg. 7-.
@article{a9781f1da8c64bf1af8f62fd6189341a,
title = "Engineering of Nanofibrous Amorphous and Crystalline Solid Dispersions for Oral Drug Delivery",
abstract = "Poor aqueous solubility (<0.1 mg/mL) affects a significant number of drugs currently on the market or under development. Several formulation strategies including salt formation, particle size reduction, and solid dispersion approaches have been employed with varied success. In this review, we focus primarily on the emerging trends in the generation of amorphous and micro/nano-crystalline solid dispersions using electrospinning to improve the dissolution rate and in turn the bioavailability of poorly water-soluble drugs. Electrospinning is a simple but versatile process that utilizes electrostatic forces to generate polymeric fibers and has been used for over 100 years to generate synthetic fibers. We discuss the various electrospinning studies and spinneret types that have been used to generate amorphous and crystalline solid dispersions.",
author = "{Keating, A.; De F{\'a}tima Pina, M.; Raimi-Abraham, B.} and {Modica De Mohac}, Laura",
year = "2018",
language = "English",
volume = "11",
pages = "7--",
journal = "Pharmaceutics",
issn = "1999-4923",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

}

TY - JOUR

T1 - Engineering of Nanofibrous Amorphous and Crystalline Solid Dispersions for Oral Drug Delivery

AU - Keating, A.; De Fátima Pina, M.; Raimi-Abraham, B.

AU - Modica De Mohac, Laura

PY - 2018

Y1 - 2018

N2 - Poor aqueous solubility (<0.1 mg/mL) affects a significant number of drugs currently on the market or under development. Several formulation strategies including salt formation, particle size reduction, and solid dispersion approaches have been employed with varied success. In this review, we focus primarily on the emerging trends in the generation of amorphous and micro/nano-crystalline solid dispersions using electrospinning to improve the dissolution rate and in turn the bioavailability of poorly water-soluble drugs. Electrospinning is a simple but versatile process that utilizes electrostatic forces to generate polymeric fibers and has been used for over 100 years to generate synthetic fibers. We discuss the various electrospinning studies and spinneret types that have been used to generate amorphous and crystalline solid dispersions.

AB - Poor aqueous solubility (<0.1 mg/mL) affects a significant number of drugs currently on the market or under development. Several formulation strategies including salt formation, particle size reduction, and solid dispersion approaches have been employed with varied success. In this review, we focus primarily on the emerging trends in the generation of amorphous and micro/nano-crystalline solid dispersions using electrospinning to improve the dissolution rate and in turn the bioavailability of poorly water-soluble drugs. Electrospinning is a simple but versatile process that utilizes electrostatic forces to generate polymeric fibers and has been used for over 100 years to generate synthetic fibers. We discuss the various electrospinning studies and spinneret types that have been used to generate amorphous and crystalline solid dispersions.

UR - http://hdl.handle.net/10447/332900

M3 - Article

VL - 11

SP - 7-

JO - Pharmaceutics

JF - Pharmaceutics

SN - 1999-4923

ER -