TY - JOUR
T1 - Endothelial progenitor cells: Are they displaying a function in autoimmune disorders?
AU - Guggino, Giuliana
AU - Triolo, Giovanni
AU - Sireci, Guido
AU - Di Liberto, Diana
AU - Balistreri, Carmela Rita
AU - Ferrante, Angelo
AU - Ciccia, Francesco
AU - Giacomelli, Roberto
AU - Cipriani, Paola
PY - 2016
Y1 - 2016
N2 - Endothelial Progenitor Cells (EPCs) are bone marrow derived cells able to differentiate in mature endothelial cells (EC) contributing to the generation of new vessels, connecting to fibronectin, and forming colonies and/or colony forming units.Since circulating EPCs can be actively considered part of endothelial damage in several cardiovascular diseases and autoimmune disorders the possibility to have a measure for endothelium damage should be considered of interest to predict the patient out-come. At the same time the EPCs proliferative and regenerative role could be considered for therapeutic applications.Studies have been performed to elucidate the role of EPCs in Systemic Sclerosis and many review and articles published on this topic.In the present paper we aimed to review the role of EPCs in other autoimmune disorders.
AB - Endothelial Progenitor Cells (EPCs) are bone marrow derived cells able to differentiate in mature endothelial cells (EC) contributing to the generation of new vessels, connecting to fibronectin, and forming colonies and/or colony forming units.Since circulating EPCs can be actively considered part of endothelial damage in several cardiovascular diseases and autoimmune disorders the possibility to have a measure for endothelium damage should be considered of interest to predict the patient out-come. At the same time the EPCs proliferative and regenerative role could be considered for therapeutic applications.Studies have been performed to elucidate the role of EPCs in Systemic Sclerosis and many review and articles published on this topic.In the present paper we aimed to review the role of EPCs in other autoimmune disorders.
UR - http://hdl.handle.net/10447/204275
UR - http://www.elsevier.com/locate/mechagedev
M3 - Article
VL - 159
SP - 44
EP - 48
JO - Mechanisms of Ageing and Development
JF - Mechanisms of Ageing and Development
SN - 0047-6374
ER -