Emerging insights on the biological impact of extracellular vesicle-associated ncRNAs in multiple Myeloma

Riccardo Alessandro, Alice Conigliaro, Stefania Raimondo, Nicola Amodio, Riccardo Alessandro, Lavinia Raimondi, Lavinia Raimondi

Risultato della ricerca: Articlepeer review

3 Citazioni (Scopus)

Abstract

Increasing evidence indicates that extracellular vesicles (EVs) released from both tumor cells and the cells of the bone marrow microenvironment contribute to the pathobiology of multiple myeloma (MM). Recent studies on the mechanisms by which EVs exert their biological activity have indicated that the non-coding RNA (ncRNA) cargo is key in mediating their effect on MM development and progression. In this review, we will first discuss the role of EV-associated ncRNAs in different aspects of MM pathobiology, including proliferation, angiogenesis, bone disease development, and drug resistance. Finally, since ncRNAs carried by MM vesicles have also emerged as a promising tool for early diagnosis and therapy response prediction, we will report evidence of their potential use as clinical biomarkers.
Lingua originaleEnglish
pagine (da-a)1-17
Numero di pagine17
RivistaNon-coding RNA
Volume6
Stato di pubblicazionePublished - 2020

All Science Journal Classification (ASJC) codes

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