Hypertriglyceridemia is frequent in diabetic and obese subjects, who are at increased risk for cardiovascular diseases (CVD). Increased triglycerides (TG) are a hallmark of atherogenic dyslipidemia, representing a marker of atherogenic small dense low-density lipoproteins (sdlDL). Importantly, non-fasting/postprandial TG measurements tend to be emphasized in clinical practice for the prediction of CVD, and TG-lowering agents (primarily fibrates) have a beneficial effect on atherogenic dyslipidemia, reducing TG-rich particles and ultimately lowering the production of sdlDL. The combination of omega-3 fatty acids and statins is also recommended, and widely used in clinical practice for subjects with hypertriglyceridemia. However, a consensus on the optimal clinical use of these pharmacological agents is not fully established yet, and additional large clinical studies are needed. It seems that there is a favorable association between fish consumption and mortality from CVD, but it remains to be confirmed by future trials. Finally, there are a number of novel therapies, such as those targeting microsomal transport protein and its inhibitors, which represent new promising option for treating subjects with hypertriglyceridemia.
|Numero di pagine||5|
|Rivista||Expert Opinion on Pharmacotherapy|
|Stato di pubblicazione||Published - 2013|
All Science Journal Classification (ASJC) codes
- Pharmacology (medical)
Nikolic, D., Montalto, G., Rizzo, M., Perez-Martinez, P., Lopez-Miranda, J., & Rizzo, M. (2013). Emerging approaches for the treatment of hypertriglyceridemia. Expert Opinion on Pharmacotherapy, 14, 1869-1873.