Emergency management in patients with haemophilia A and inhibitors on prophylaxis with emicizumab: AICE practical guidance in collaboration with SIBioC, SIMEU, SIMEUP, SIPMeL and SISET

Sergio Siragusa, Massimo Morfini, Gianna Franca Rivolta, Maria Golato, Chiara Biasoli, Emanuela Marchesini, Vittorio Sargentini, Armando Tripodi, Lucia D. Notarangelo, Anna Chiara, Andrea Fabbri, Sophie Testa, Antonio Coppola, Dorina Cultrera, Renato Marino, Francesco R. Pugliese, Gabriella Gamba, Angelo C. Molinari, Antonella Coluccia, Ezio ZanonFlora Peyvandi, Alberto Catalano, Laura Sciacovelli, Alberto Catalano, Anna Chiara, Alessandra Borchiellini, Lucia Peccarisi, Stefania Zampogna, Berardino Pollio, Laura Sciacovelli, Adele Giampaolo, Maria Golato, Laura Contino, Angiola Rocino, Maria Luisa Serino, Riccardo Lubrano, Alberto Tosetto, Maria Gabriella Mazzucconi, Mario Schiavoni, Elena Santagostino, Cristina Santoro, Annarita Tagliaferri, Giancarlo Castaman, Paolo Gresele, Giovanni Di Minno, Raimondo De Cristofaro, Sergio Bernardini, Matteo Luciani, Rita C. Santoro, Maria Pia Ruggieri, Massimo Franchini, Hamisa J. Hassan, Maria E. Mancuso

Risultato della ricerca: Articlepeer review

15 Citazioni (Scopus)

Abstract

Emicizumab has been approved in several countries for regular prophylaxis in patients with congenital haemophilia A and FVIII inhibitors because it substantially reduces their bleeding risk and improves quality of life. However, although significantly less frequent, some breakthrough bleeds may still occur while on emicizumab, requiring treatment with bypassing or other haemostatic agents. Thrombotic complications have been reported with the associated use of activated prothrombin complex concentrates. In addition, when surgery/invasive procedures are needed while on emicizumab, their management requires multidisciplinary competences and direct supervision by experts in the use of this agent. Given this, and in order to expand the current knowledge on the use of emicizumab and concomitant haemostatic agents, and reduce the risk of complications in this setting, the Italian Association of Haemophilia Centres (AICE) here provides guidance on the management of breakthrough bleeds and surgery in emergency situations in patients with haemophilia A and inhibitors on emicizumab prophylaxis. This paper has been shared with other National Scientific Societies involved in the field.
Lingua originaleEnglish
pagine (da-a)143-151-
Numero di pagine9
RivistaBLOOD TRANSFUSION
Volume18
Stato di pubblicazionePublished - 2020

All Science Journal Classification (ASJC) codes

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