ELF regimen in advanced gastrointestinal malignancies: An analysis of its clinical effectiveness and toxicity

Nicolo' Gebbia, Calogero Cipolla, Carmelo Sciume', Vittorio Gebbia, Fortunato, Nicola Gebbia, Vittorio Gebbia, Pietro Leo, Cusumano, Leo, Curto, Verderame, Valenza, Carmelo Sciume, Cannata, Calogero Cipolla C., Di Gesu, Testa, Giuseppe Di Gesu', Pietro Leo

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A multi-institutional phase II study of the combination of levofolinic acid 100 mg/m2, VP16 120 mg/m2 and 5-fluorouracil 500 mg/m2 for 3 consecutive days was carried out on a series of 73 evaluable patients with low performance status affected by locally advanced and/or metastatic gastrointestinal carcinomas. Site of primary tumor were: stomach 26, large bowel 20, pancreas 16, gall-bladder 5, and liver 6. Among patients with gastric carcinoma, 2 patients (8%) had a complete response with a mean duration of 6.8+ months, for an overall response rate of 43%. Overall response rate was largely unsatisfactory in colorectal carcinoma (20%), pancreatic (12%), gall-bladder and liver carcinomas. The treatment was very well tolerated with no grade 4 toxicity over a total of 267 cycles administered. Grade 3 leukopenia was seen in 25% of cases, and grade 2 thrombocytopenia in 18%. Vomiting never exceeded grade 2. Thus, the ELF regimen is quite active in advanced gastric carcinoma, and may be recommended as palliative treatment of patients who cannot receive intensive chemotherapy. On the other hand, it cannot be considered active in colorectal, pancreatic, gall-bladder and liver carcinomas, and its use should be discouraged in these neoplasms.
Lingua originaleEnglish
pagine (da-a)411-415
Numero di pagine5
RivistaInternational Journal of Oncology
Stato di pubblicazionePublished - 1994

All Science Journal Classification (ASJC) codes

  • ???subjectarea.asjc.2700.2730???
  • ???subjectarea.asjc.1300.1306???


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