ELF regimen in advanced gastrointestinal malignancies: An analysis of its clinical effectiveness and toxicity

Vittorio Gebbia, Calogero Cipolla, Nicolo' Gebbia, Carmelo Sciume', Fortunato, Nicola Gebbia, Vittorio Gebbia, Pietro Leo, Cusumano, Leo, Curto, Verderame, Valenza, Carmelo Sciume, Cannata, Calogero Cipolla C., Di Gesu, Testa, Giuseppe Di Gesu', Pietro Leo

Risultato della ricerca: Article

Abstract

A multi-institutional phase II study of the combination of levofolinic acid 100 mg/m2, VP16 120 mg/m2 and 5-fluorouracil 500 mg/m2 for 3 consecutive days was carried out on a series of 73 evaluable patients with low performance status affected by locally advanced and/or metastatic gastrointestinal carcinomas. Site of primary tumor were: stomach 26, large bowel 20, pancreas 16, gall-bladder 5, and liver 6. Among patients with gastric carcinoma, 2 patients (8%) had a complete response with a mean duration of 6.8+ months, for an overall response rate of 43%. Overall response rate was largely unsatisfactory in colorectal carcinoma (20%), pancreatic (12%), gall-bladder and liver carcinomas. The treatment was very well tolerated with no grade 4 toxicity over a total of 267 cycles administered. Grade 3 leukopenia was seen in 25% of cases, and grade 2 thrombocytopenia in 18%. Vomiting never exceeded grade 2. Thus, the ELF regimen is quite active in advanced gastric carcinoma, and may be recommended as palliative treatment of patients who cannot receive intensive chemotherapy. On the other hand, it cannot be considered active in colorectal, pancreatic, gall-bladder and liver carcinomas, and its use should be discouraged in these neoplasms.
Lingua originaleEnglish
pagine (da-a)411-415
Numero di pagine5
RivistaInternational Journal of Oncology
Volume4
Stato di pubblicazionePublished - 1994

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Carcinoma
Stomach
Urinary Bladder
Neoplasms
Liver
Leukopenia
Palliative Care
Fluorouracil
Vomiting
Pancreas
Colorectal Neoplasms
Drug Therapy
Acids
Therapeutics

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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ELF regimen in advanced gastrointestinal malignancies: An analysis of its clinical effectiveness and toxicity. / Gebbia, Vittorio; Cipolla, Calogero; Gebbia, Nicolo'; Sciume', Carmelo; Fortunato; Gebbia, Nicola; Gebbia, Vittorio; Leo, Pietro; Cusumano; Leo; Curto; Verderame; Valenza; Sciume, Carmelo; Cannata; Cipolla C., Calogero; Di Gesu; Testa; Di Gesu', Giuseppe; Leo, Pietro.

In: International Journal of Oncology, Vol. 4, 1994, pag. 411-415.

Risultato della ricerca: Article

Gebbia, V, Cipolla, C, Gebbia, N, Sciume', C, Fortunato, Gebbia, N, Gebbia, V, Leo, P, Cusumano, Leo, Curto, Verderame, Valenza, Sciume, C, Cannata, Cipolla C., C, Di Gesu, Testa, Di Gesu', G & Leo, P 1994, 'ELF regimen in advanced gastrointestinal malignancies: An analysis of its clinical effectiveness and toxicity', International Journal of Oncology, vol. 4, pagg. 411-415.
Gebbia, Vittorio ; Cipolla, Calogero ; Gebbia, Nicolo' ; Sciume', Carmelo ; Fortunato ; Gebbia, Nicola ; Gebbia, Vittorio ; Leo, Pietro ; Cusumano ; Leo ; Curto ; Verderame ; Valenza ; Sciume, Carmelo ; Cannata ; Cipolla C., Calogero ; Di Gesu ; Testa ; Di Gesu', Giuseppe ; Leo, Pietro. / ELF regimen in advanced gastrointestinal malignancies: An analysis of its clinical effectiveness and toxicity. In: International Journal of Oncology. 1994 ; Vol. 4. pagg. 411-415.
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abstract = "A multi-institutional phase II study of the combination of levofolinic acid 100 mg/m2, VP16 120 mg/m2 and 5-fluorouracil 500 mg/m2 for 3 consecutive days was carried out on a series of 73 evaluable patients with low performance status affected by locally advanced and/or metastatic gastrointestinal carcinomas. Site of primary tumor were: stomach 26, large bowel 20, pancreas 16, gall-bladder 5, and liver 6. Among patients with gastric carcinoma, 2 patients (8{\%}) had a complete response with a mean duration of 6.8+ months, for an overall response rate of 43{\%}. Overall response rate was largely unsatisfactory in colorectal carcinoma (20{\%}), pancreatic (12{\%}), gall-bladder and liver carcinomas. The treatment was very well tolerated with no grade 4 toxicity over a total of 267 cycles administered. Grade 3 leukopenia was seen in 25{\%} of cases, and grade 2 thrombocytopenia in 18{\%}. Vomiting never exceeded grade 2. Thus, the ELF regimen is quite active in advanced gastric carcinoma, and may be recommended as palliative treatment of patients who cannot receive intensive chemotherapy. On the other hand, it cannot be considered active in colorectal, pancreatic, gall-bladder and liver carcinomas, and its use should be discouraged in these neoplasms.",
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AU - Gebbia, Vittorio

AU - Cipolla, Calogero

AU - Gebbia, Nicolo'

AU - Sciume', Carmelo

AU - Fortunato, null

AU - Gebbia, Nicola

AU - Gebbia, Vittorio

AU - Leo, Pietro

AU - Cusumano, null

AU - Leo, null

AU - Curto, null

AU - Verderame, null

AU - Valenza, null

AU - Sciume, Carmelo

AU - Cannata, null

AU - Cipolla C., Calogero

AU - Di Gesu, null

AU - Testa, null

AU - Di Gesu', Giuseppe

AU - Leo, Pietro

PY - 1994

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N2 - A multi-institutional phase II study of the combination of levofolinic acid 100 mg/m2, VP16 120 mg/m2 and 5-fluorouracil 500 mg/m2 for 3 consecutive days was carried out on a series of 73 evaluable patients with low performance status affected by locally advanced and/or metastatic gastrointestinal carcinomas. Site of primary tumor were: stomach 26, large bowel 20, pancreas 16, gall-bladder 5, and liver 6. Among patients with gastric carcinoma, 2 patients (8%) had a complete response with a mean duration of 6.8+ months, for an overall response rate of 43%. Overall response rate was largely unsatisfactory in colorectal carcinoma (20%), pancreatic (12%), gall-bladder and liver carcinomas. The treatment was very well tolerated with no grade 4 toxicity over a total of 267 cycles administered. Grade 3 leukopenia was seen in 25% of cases, and grade 2 thrombocytopenia in 18%. Vomiting never exceeded grade 2. Thus, the ELF regimen is quite active in advanced gastric carcinoma, and may be recommended as palliative treatment of patients who cannot receive intensive chemotherapy. On the other hand, it cannot be considered active in colorectal, pancreatic, gall-bladder and liver carcinomas, and its use should be discouraged in these neoplasms.

AB - A multi-institutional phase II study of the combination of levofolinic acid 100 mg/m2, VP16 120 mg/m2 and 5-fluorouracil 500 mg/m2 for 3 consecutive days was carried out on a series of 73 evaluable patients with low performance status affected by locally advanced and/or metastatic gastrointestinal carcinomas. Site of primary tumor were: stomach 26, large bowel 20, pancreas 16, gall-bladder 5, and liver 6. Among patients with gastric carcinoma, 2 patients (8%) had a complete response with a mean duration of 6.8+ months, for an overall response rate of 43%. Overall response rate was largely unsatisfactory in colorectal carcinoma (20%), pancreatic (12%), gall-bladder and liver carcinomas. The treatment was very well tolerated with no grade 4 toxicity over a total of 267 cycles administered. Grade 3 leukopenia was seen in 25% of cases, and grade 2 thrombocytopenia in 18%. Vomiting never exceeded grade 2. Thus, the ELF regimen is quite active in advanced gastric carcinoma, and may be recommended as palliative treatment of patients who cannot receive intensive chemotherapy. On the other hand, it cannot be considered active in colorectal, pancreatic, gall-bladder and liver carcinomas, and its use should be discouraged in these neoplasms.

KW - Cancer Research

KW - Colorectal cancer

KW - ELF regimen

KW - Etoposide

KW - Fluorouracil

KW - Folinic acid

KW - Gall-bladder cancer

KW - Gastric cancer

KW - Liver cancer

KW - Oncology

KW - Pancreatic cancer

UR - http://hdl.handle.net/10447/220513

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JO - International Journal of Oncology

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