Electrospun Polyhydroxyethyl-Aspartamide-Polylactic Acid Scaffold for Biliary Duct Repair: A Preliminary In Vivo Evaluation

Vincenzo Davide Palumbo, Fabio Salvatore Palumbo, Attilio Ignazio Lo Monte, Mariano Licciardi, Giovanni Cassata, Calogero Fiorica, Giuseppe Damiano, Giuseppe Buscemi, Salvatore Buscemi, Giuseppe Damiano, Giovanni Cassata, Silvia Ficarella, Angela Maffongelli, Salvatore Fazzotta, Salvatore Fazzotta, Leonardo Gulotta, Attilio Ignazio Lo Monte, Vincenzo Davide Palumbo, Giuseppe Buscemi, Silvia Ficarella

Risultato della ricerca: Articlepeer review

5 Citazioni (Scopus)


Tissue engineering has emerged as a new approach with the potential to overcome the limitations of traditional therapies. The objective of this study was to test whether our polymeric scaffold is able to resist the corrosive action of bile and to support a cell's infiltration and neoangiogenesis with the aim of using it as a biodegradable tissue substitute for serious bile duct injuries. In particular, a resorbable electrospun polyhydroxyethyl-aspartamide-polylactic acid (90 mol% PHEA, 10 mol% PLA)/polycaprolactone (50:50 w/w) plate scaffold was implanted into rabbit gallbladder to assess the in vivo effects of the lytic action of the bile on the scaffold structure and then as a tubular scaffold to create a biliary-digestive anastomosis as well. For the above evaluation, 5 animals were used and killed after 15 days and 5 animals after 3 months. At 15-day and 3-month follow-ups, the fibrillar structure was not digested by lytic action bile. The fibers of the scaffold were organized despite being in contact with bile action. A new epithelial tissue appeared on the scaffold surface suggesting the suitability of this scaffold for future studies of the repair of biliary tract injuries with the use of resorbable copolymer on biliary injuries.
Lingua originaleEnglish
pagine (da-a)711-715
Numero di pagine5
RivistaTransplantation Proceedings
Stato di pubblicazionePublished - 2017

All Science Journal Classification (ASJC) codes

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