Background and Objectives: 1,2,4-Oxadiazoles show a high reactivity and represent starting compounds for the synthesis of several other heterocycles. Some their derivatives can give the so called Boulton-Katritzky Reactions (BKR) which opens the way to the synthesis of several azoles. For this reason we have registered the mass spectra of several 3-aroylamino-5-methyl-1,2,4-oxadiazoles and 3-acetylamino-5-aryl1,2,4-oxadiazoles.Methods and Results: Thus, studying the mass spectra of the isomeric couple 3-benzoylamino-5-methyl-1,2,4-oxadiazole (1A) and 3-acetylamino-5-phenyl-1,2,4-oxadiazoles (1B) we have observed that MIKE and CID MIKE spectra of their molecular ions and of the [M - CH2CO](+). evidence that several fragmentation processes arise from common structure(s).Conclusions: These findings lead to suggest that the BKR could occur also under electron ionization. In order to evidence possible substituent effects the EI-MS spectra of a large series of 3-aroylamino-5-methyl-1,2,4-oxadiazoles (2A-19A) and of the corresponding 3-acetylamino-5-aryl-1,2,4-oxadiazoles (2B-19B) have been examined.
|Numero di pagine||9|
|Rivista||Current Organic Chemistry|
|Stato di pubblicazione||Published - 2017|
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