Electrocortical networks in Parkinson's disease patients with Mild Cognitive Impairment. The PaCoS study

Vincenzo Restivo, Roberto Monastero, Antonina Luca, Giovanni Mostile, Valeria Dibilio, Giulia Donzuso, Loretta Giuliano, Calogero Edoardo Cicero, Roberta Terranova, Vito Sofia, Mario Zappia, Alessandra Nicoletti, Roberta Baschi

Risultato della ricerca: Article

1 Citazione (Scopus)

Abstract

Introduction: Parkinson's Disease (PD) is frequently associated with cognitive dysfunction ranging from Mild Cognitive Impairment (PD-MCI) to dementia. Few electrophysiological studies are available evaluating potential pathogenetic mechanisms linked to cognitive impairment in PD since its initial phases. The objective of the study is to analyze electrocortical networks related with cognitive decline in PD-MCI for identifying possible early electrophysiological markers of cognitive impairment in PD. Methods: From the PaCoS (Parkinson's disease Cognitive impairment Study) cohort, a sample of 102 subjects including 46 PD-MCI and 56 PD with normal cognition (PD-NC) was selected based on the presence of a neuropsychological assessment and at least one EEG recording. EEG signal epochs were analysed using Independent Component Analysis LORETA and spectral analysis by computing the Power Spectral Density (PSD) of site-specific signal epochs. Results: LORETA analysis revealed significant differences in PD-MCI patients compared to PD-NC, with a decreased network involving alpha activity over the occipital lobe, an increased network involving beta activity over the frontal lobe associated with a reduction over the parietal lobe, an increased network involving theta and delta activity over the frontal lobe and a reduction of networks involving theta and delta activity in the parietal lobe. Quantitative EEG analysis showed a significant decrease of alpha PSD over the occipital regions and an increase of delta PSD over the left temporal region in PD-MCI as compared to PD-NC. Conclusion: Electrocortical abnormalities detected in PD-MCI patients may represent the instrumental counterpart of early cognitive decline in PD.
Lingua originaleEnglish
pagine (da-a)156-162
Numero di pagine7
RivistaPARKINSONISM & RELATED DISORDERS
Volume64
Stato di pubblicazionePublished - 2019

Fingerprint

Parkinson Disease
Electroencephalography
Occipital Lobe
Parietal Lobe
Frontal Lobe
Cognitive Dysfunction
Temporal Lobe
Cognition
Dementia
Cohort Studies

All Science Journal Classification (ASJC) codes

  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology

Cita questo

Electrocortical networks in Parkinson's disease patients with Mild Cognitive Impairment. The PaCoS study. / Restivo, Vincenzo; Monastero, Roberto; Luca, Antonina; Mostile, Giovanni; Dibilio, Valeria; Donzuso, Giulia; Giuliano, Loretta; Cicero, Calogero Edoardo; Terranova, Roberta; Sofia, Vito; Zappia, Mario; Nicoletti, Alessandra; Baschi, Roberta.

In: PARKINSONISM & RELATED DISORDERS, Vol. 64, 2019, pag. 156-162.

Risultato della ricerca: Article

Restivo, V, Monastero, R, Luca, A, Mostile, G, Dibilio, V, Donzuso, G, Giuliano, L, Cicero, CE, Terranova, R, Sofia, V, Zappia, M, Nicoletti, A & Baschi, R 2019, 'Electrocortical networks in Parkinson's disease patients with Mild Cognitive Impairment. The PaCoS study', PARKINSONISM & RELATED DISORDERS, vol. 64, pagg. 156-162.
Restivo, Vincenzo ; Monastero, Roberto ; Luca, Antonina ; Mostile, Giovanni ; Dibilio, Valeria ; Donzuso, Giulia ; Giuliano, Loretta ; Cicero, Calogero Edoardo ; Terranova, Roberta ; Sofia, Vito ; Zappia, Mario ; Nicoletti, Alessandra ; Baschi, Roberta. / Electrocortical networks in Parkinson's disease patients with Mild Cognitive Impairment. The PaCoS study. In: PARKINSONISM & RELATED DISORDERS. 2019 ; Vol. 64. pagg. 156-162.
@article{91a200fad97e4d7eaa218d6da902c147,
title = "Electrocortical networks in Parkinson's disease patients with Mild Cognitive Impairment. The PaCoS study",
abstract = "Introduction: Parkinson's Disease (PD) is frequently associated with cognitive dysfunction ranging from Mild Cognitive Impairment (PD-MCI) to dementia. Few electrophysiological studies are available evaluating potential pathogenetic mechanisms linked to cognitive impairment in PD since its initial phases. The objective of the study is to analyze electrocortical networks related with cognitive decline in PD-MCI for identifying possible early electrophysiological markers of cognitive impairment in PD. Methods: From the PaCoS (Parkinson's disease Cognitive impairment Study) cohort, a sample of 102 subjects including 46 PD-MCI and 56 PD with normal cognition (PD-NC) was selected based on the presence of a neuropsychological assessment and at least one EEG recording. EEG signal epochs were analysed using Independent Component Analysis LORETA and spectral analysis by computing the Power Spectral Density (PSD) of site-specific signal epochs. Results: LORETA analysis revealed significant differences in PD-MCI patients compared to PD-NC, with a decreased network involving alpha activity over the occipital lobe, an increased network involving beta activity over the frontal lobe associated with a reduction over the parietal lobe, an increased network involving theta and delta activity over the frontal lobe and a reduction of networks involving theta and delta activity in the parietal lobe. Quantitative EEG analysis showed a significant decrease of alpha PSD over the occipital regions and an increase of delta PSD over the left temporal region in PD-MCI as compared to PD-NC. Conclusion: Electrocortical abnormalities detected in PD-MCI patients may represent the instrumental counterpart of early cognitive decline in PD.",
author = "Vincenzo Restivo and Roberto Monastero and Antonina Luca and Giovanni Mostile and Valeria Dibilio and Giulia Donzuso and Loretta Giuliano and Cicero, {Calogero Edoardo} and Roberta Terranova and Vito Sofia and Mario Zappia and Alessandra Nicoletti and Roberta Baschi",
year = "2019",
language = "English",
volume = "64",
pages = "156--162",
journal = "PARKINSONISM & RELATED DISORDERS",
issn = "1353-8020",

}

TY - JOUR

T1 - Electrocortical networks in Parkinson's disease patients with Mild Cognitive Impairment. The PaCoS study

AU - Restivo, Vincenzo

AU - Monastero, Roberto

AU - Luca, Antonina

AU - Mostile, Giovanni

AU - Dibilio, Valeria

AU - Donzuso, Giulia

AU - Giuliano, Loretta

AU - Cicero, Calogero Edoardo

AU - Terranova, Roberta

AU - Sofia, Vito

AU - Zappia, Mario

AU - Nicoletti, Alessandra

AU - Baschi, Roberta

PY - 2019

Y1 - 2019

N2 - Introduction: Parkinson's Disease (PD) is frequently associated with cognitive dysfunction ranging from Mild Cognitive Impairment (PD-MCI) to dementia. Few electrophysiological studies are available evaluating potential pathogenetic mechanisms linked to cognitive impairment in PD since its initial phases. The objective of the study is to analyze electrocortical networks related with cognitive decline in PD-MCI for identifying possible early electrophysiological markers of cognitive impairment in PD. Methods: From the PaCoS (Parkinson's disease Cognitive impairment Study) cohort, a sample of 102 subjects including 46 PD-MCI and 56 PD with normal cognition (PD-NC) was selected based on the presence of a neuropsychological assessment and at least one EEG recording. EEG signal epochs were analysed using Independent Component Analysis LORETA and spectral analysis by computing the Power Spectral Density (PSD) of site-specific signal epochs. Results: LORETA analysis revealed significant differences in PD-MCI patients compared to PD-NC, with a decreased network involving alpha activity over the occipital lobe, an increased network involving beta activity over the frontal lobe associated with a reduction over the parietal lobe, an increased network involving theta and delta activity over the frontal lobe and a reduction of networks involving theta and delta activity in the parietal lobe. Quantitative EEG analysis showed a significant decrease of alpha PSD over the occipital regions and an increase of delta PSD over the left temporal region in PD-MCI as compared to PD-NC. Conclusion: Electrocortical abnormalities detected in PD-MCI patients may represent the instrumental counterpart of early cognitive decline in PD.

AB - Introduction: Parkinson's Disease (PD) is frequently associated with cognitive dysfunction ranging from Mild Cognitive Impairment (PD-MCI) to dementia. Few electrophysiological studies are available evaluating potential pathogenetic mechanisms linked to cognitive impairment in PD since its initial phases. The objective of the study is to analyze electrocortical networks related with cognitive decline in PD-MCI for identifying possible early electrophysiological markers of cognitive impairment in PD. Methods: From the PaCoS (Parkinson's disease Cognitive impairment Study) cohort, a sample of 102 subjects including 46 PD-MCI and 56 PD with normal cognition (PD-NC) was selected based on the presence of a neuropsychological assessment and at least one EEG recording. EEG signal epochs were analysed using Independent Component Analysis LORETA and spectral analysis by computing the Power Spectral Density (PSD) of site-specific signal epochs. Results: LORETA analysis revealed significant differences in PD-MCI patients compared to PD-NC, with a decreased network involving alpha activity over the occipital lobe, an increased network involving beta activity over the frontal lobe associated with a reduction over the parietal lobe, an increased network involving theta and delta activity over the frontal lobe and a reduction of networks involving theta and delta activity in the parietal lobe. Quantitative EEG analysis showed a significant decrease of alpha PSD over the occipital regions and an increase of delta PSD over the left temporal region in PD-MCI as compared to PD-NC. Conclusion: Electrocortical abnormalities detected in PD-MCI patients may represent the instrumental counterpart of early cognitive decline in PD.

UR - http://hdl.handle.net/10447/390486

UR - http://www.elsevier.com/locate/parkreldis

M3 - Article

VL - 64

SP - 156

EP - 162

JO - PARKINSONISM & RELATED DISORDERS

JF - PARKINSONISM & RELATED DISORDERS

SN - 1353-8020

ER -