Natural oligosaccharides inhibitors of heparanase and selectins are emerging as promising drugs forcancer therapy. As an alternative tool to the natural ones, sulfated tri maltose C-C-linked dimers(alfa,alfa alfa,beta and beta,beta STMCs) were prepared by bromo-maltotriose electroreduction on silver cathode,1followed by sulfation. The presence of an interglycosidic C-C bond makes STMCs less vulnerableto metabolic processing then their O-analogues. For this reason, STMCs have been studied as drugcandidates and inhibitors of carbohydrate processing enzymes. Their activity as inhibitor of Pselectinin vivo and in the attenuation of metastasis both on B16-BL6 melanoma cells and on MC-38 carcinoma cells2 prompted to the optimization of their synthetic process. Therefore, theelectrochemical process for the C-C coupling of the model molecule acetobromoglucose has beeninvestigated by changing various reaction conditions such as solvent and arrangement of theelectrolytic cell, aiming at the final scale-up of the reaction.
|Numero di pagine||1|
|Stato di pubblicazione||Published - 2012|