Electrical characterization of deoxyribonucleic acid hybridization in metal-oxide-semiconductor-like structures

Alessandro Busacca, Aiello, Cannella, Lombardo, Libertino

Risultato della ricerca: Article

4 Citazioni (Scopus)


In this work, metal-oxide-semiconductor (MOS)-like sensors in which deoxyribonucleic acid (DNA) strands are covalently immobilized either on Si oxide or on a gold surface were electrically characterized. Si oxide fabrication process allowed us to have a surface insensitive to the solution pH. A significant shift in the flat band voltage was measured after single strand DNA immobilization (+0.47 ± 0.04 V) and after the complementary strand binding (+0.07 ± 0.02 V). The results show that DNA sensing can be performed using a MOS structure which can be easily integrated in a more complex design, thus avoiding the problems related to the integration of micro-electrochemical cells.
Lingua originaleEnglish
Numero di pagine4
RivistaApplied Physics Letters
Stato di pubblicazionePublished - 2012


All Science Journal Classification (ASJC) codes

  • Physics and Astronomy (miscellaneous)

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