Eight-membered heterocycles with two heteroatoms in a 1,5-relationship of interest in medicinal chemistry

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Abstract

This review deals with 1,5-diheterocines that exhibited biological properties and covers comprehensively the literature from 2007 to the end of February 2019. Among the six possible heterocyclic systems belonging to the eight-membered rings with two heteroatoms, N, O, and S, five had derivatives showing pharmacological activities: 1,5-diazocines, 1,5-oxazocines, 1,5-thiazocines, 1,5-dioxocins, and 1,5-dithiocins. Instead, literature reported no articles dealing with 1,5-oxathiocins of interest in medicinal chemistry. In addition to uncondensed derivatives, 1,5-diheterocines fused to five- and six-membered carbocycles or heterocycles are covered. Bridged 1,5-diheterocines are covered as well.
Lingua originaleEnglish
Titolo della pubblicazione ospiteAdvances in Heterocyclic Chemistry
Pagine135-239
Numero di pagine105
Stato di pubblicazionePublished - 2020

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Organic Chemistry
  • Polymers and Plastics

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