Efficacy and Safety of Using High-Flow Nasal Oxygenation in Patients Undergoing Rapid Sequence Intubation.

Santi Maurizio Raineri, Cesare Gregoretti, Antonino Giarratano, Andrea Cortegiani, Claudia Procaccianti, Filippo Vitale, Giuseppe Accurso, Sabrina Caruso

Risultato della ricerca: Article

3 Citazioni (Scopus)

Abstract

Objective: To assess the efficacy and safety of high-flow nasal oxygen (HFNO) therapy in patients undergoing rapid sequence intubation (RSI) for emergency abdominal surgery. Methods: HFNO of 60 L.minâ1at an inspiratory oxygen fraction of 1 was delivered 4 min before laryngoscopy and maintained until the patient was intubated, and correct intubation was verified by the appearance of the end-tidal CO2(EtCO2) waveform. Transcutaneous oxygenation (SpO2), heart rate and non-invasive mean arterial pressure were monitored at baseline (T0), after 4 min on HFNO (T1) and at the time of laryngoscopy (T2) and endotracheal intubation (ETI) (T3). An SpO2of <3% from baseline was recorded at any sampled time. The value of EtCO2at T3 was registered after two mechanical breaths. The apnoea time was defined as the time from the end of propofol injection to ETI. RSI was performed with propofol, fentanyl and rocuronium. Results: Forty-five patients were enrolled. SpO2levels showed a statistically significant increase at T1, T2 and T3 compared with those at T0 (p<0.05); median SpO2% (interquartile range) was 97% (range, 96%-99%) at T0, 99% (range, 99%-100%) at T1, 99% (range, 99%-100%) at T2 and 99% (range, 99%-100%) at T3. Minimal SpO2was 96%; no patient showed an SpO2of <3% from baseline; mean EtCO2at the time of ETI was 36±4 mmHg. Maximum apnoea time was 12 min. Conclusion: HFNO is an effective and safe technique for pre-oxygenation in patients undergoing rapid sequence induction of general anaesthesia for emergency surgery.
Lingua originaleEnglish
pagine (da-a)335-339
Numero di pagine5
RivistaDefault journal
Volume45
Stato di pubblicazionePublished - 2017

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Nose
Intubation
Safety
Intratracheal Intubation
Oxygen
Laryngoscopy
Propofol
Apnea
Emergencies
Fentanyl
General Anesthesia
Arterial Pressure
Heart Rate
Injections

All Science Journal Classification (ASJC) codes

  • Emergency Medicine
  • Anesthesiology and Pain Medicine

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Efficacy and Safety of Using High-Flow Nasal Oxygenation in Patients Undergoing Rapid Sequence Intubation. / Raineri, Santi Maurizio; Gregoretti, Cesare; Giarratano, Antonino; Cortegiani, Andrea; Procaccianti, Claudia; Vitale, Filippo; Accurso, Giuseppe; Caruso, Sabrina.

In: Default journal, Vol. 45, 2017, pag. 335-339.

Risultato della ricerca: Article

@article{a4e5913666584bfabac1b4cc9ac958b7,
title = "Efficacy and Safety of Using High-Flow Nasal Oxygenation in Patients Undergoing Rapid Sequence Intubation.",
abstract = "Objective: To assess the efficacy and safety of high-flow nasal oxygen (HFNO) therapy in patients undergoing rapid sequence intubation (RSI) for emergency abdominal surgery. Methods: HFNO of 60 L.min{\^a}1at an inspiratory oxygen fraction of 1 was delivered 4 min before laryngoscopy and maintained until the patient was intubated, and correct intubation was verified by the appearance of the end-tidal CO2(EtCO2) waveform. Transcutaneous oxygenation (SpO2), heart rate and non-invasive mean arterial pressure were monitored at baseline (T0), after 4 min on HFNO (T1) and at the time of laryngoscopy (T2) and endotracheal intubation (ETI) (T3). An SpO2of <3{\%} from baseline was recorded at any sampled time. The value of EtCO2at T3 was registered after two mechanical breaths. The apnoea time was defined as the time from the end of propofol injection to ETI. RSI was performed with propofol, fentanyl and rocuronium. Results: Forty-five patients were enrolled. SpO2levels showed a statistically significant increase at T1, T2 and T3 compared with those at T0 (p<0.05); median SpO2{\%} (interquartile range) was 97{\%} (range, 96{\%}-99{\%}) at T0, 99{\%} (range, 99{\%}-100{\%}) at T1, 99{\%} (range, 99{\%}-100{\%}) at T2 and 99{\%} (range, 99{\%}-100{\%}) at T3. Minimal SpO2was 96{\%}; no patient showed an SpO2of <3{\%} from baseline; mean EtCO2at the time of ETI was 36{\^A}±4 mmHg. Maximum apnoea time was 12 min. Conclusion: HFNO is an effective and safe technique for pre-oxygenation in patients undergoing rapid sequence induction of general anaesthesia for emergency surgery.",
keywords = "Anesthesiology and Pain Medicine, Emergency Medicine, High-flow nasal oxygen therapy, Pre-oxygenation, Rapid sequence intubation",
author = "Raineri, {Santi Maurizio} and Cesare Gregoretti and Antonino Giarratano and Andrea Cortegiani and Claudia Procaccianti and Filippo Vitale and Giuseppe Accurso and Sabrina Caruso",
year = "2017",
language = "English",
volume = "45",
pages = "335--339",
journal = "Default journal",

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TY - JOUR

T1 - Efficacy and Safety of Using High-Flow Nasal Oxygenation in Patients Undergoing Rapid Sequence Intubation.

AU - Raineri, Santi Maurizio

AU - Gregoretti, Cesare

AU - Giarratano, Antonino

AU - Cortegiani, Andrea

AU - Procaccianti, Claudia

AU - Vitale, Filippo

AU - Accurso, Giuseppe

AU - Caruso, Sabrina

PY - 2017

Y1 - 2017

N2 - Objective: To assess the efficacy and safety of high-flow nasal oxygen (HFNO) therapy in patients undergoing rapid sequence intubation (RSI) for emergency abdominal surgery. Methods: HFNO of 60 L.minâ1at an inspiratory oxygen fraction of 1 was delivered 4 min before laryngoscopy and maintained until the patient was intubated, and correct intubation was verified by the appearance of the end-tidal CO2(EtCO2) waveform. Transcutaneous oxygenation (SpO2), heart rate and non-invasive mean arterial pressure were monitored at baseline (T0), after 4 min on HFNO (T1) and at the time of laryngoscopy (T2) and endotracheal intubation (ETI) (T3). An SpO2of <3% from baseline was recorded at any sampled time. The value of EtCO2at T3 was registered after two mechanical breaths. The apnoea time was defined as the time from the end of propofol injection to ETI. RSI was performed with propofol, fentanyl and rocuronium. Results: Forty-five patients were enrolled. SpO2levels showed a statistically significant increase at T1, T2 and T3 compared with those at T0 (p<0.05); median SpO2% (interquartile range) was 97% (range, 96%-99%) at T0, 99% (range, 99%-100%) at T1, 99% (range, 99%-100%) at T2 and 99% (range, 99%-100%) at T3. Minimal SpO2was 96%; no patient showed an SpO2of <3% from baseline; mean EtCO2at the time of ETI was 36±4 mmHg. Maximum apnoea time was 12 min. Conclusion: HFNO is an effective and safe technique for pre-oxygenation in patients undergoing rapid sequence induction of general anaesthesia for emergency surgery.

AB - Objective: To assess the efficacy and safety of high-flow nasal oxygen (HFNO) therapy in patients undergoing rapid sequence intubation (RSI) for emergency abdominal surgery. Methods: HFNO of 60 L.minâ1at an inspiratory oxygen fraction of 1 was delivered 4 min before laryngoscopy and maintained until the patient was intubated, and correct intubation was verified by the appearance of the end-tidal CO2(EtCO2) waveform. Transcutaneous oxygenation (SpO2), heart rate and non-invasive mean arterial pressure were monitored at baseline (T0), after 4 min on HFNO (T1) and at the time of laryngoscopy (T2) and endotracheal intubation (ETI) (T3). An SpO2of <3% from baseline was recorded at any sampled time. The value of EtCO2at T3 was registered after two mechanical breaths. The apnoea time was defined as the time from the end of propofol injection to ETI. RSI was performed with propofol, fentanyl and rocuronium. Results: Forty-five patients were enrolled. SpO2levels showed a statistically significant increase at T1, T2 and T3 compared with those at T0 (p<0.05); median SpO2% (interquartile range) was 97% (range, 96%-99%) at T0, 99% (range, 99%-100%) at T1, 99% (range, 99%-100%) at T2 and 99% (range, 99%-100%) at T3. Minimal SpO2was 96%; no patient showed an SpO2of <3% from baseline; mean EtCO2at the time of ETI was 36±4 mmHg. Maximum apnoea time was 12 min. Conclusion: HFNO is an effective and safe technique for pre-oxygenation in patients undergoing rapid sequence induction of general anaesthesia for emergency surgery.

KW - Anesthesiology and Pain Medicine

KW - Emergency Medicine

KW - High-flow nasal oxygen therapy

KW - Pre-oxygenation

KW - Rapid sequence intubation

UR - http://hdl.handle.net/10447/272619

UR - http://www.jtaics.org/jvi.aspx

M3 - Article

VL - 45

SP - 335

EP - 339

JO - Default journal

JF - Default journal

ER -