Effetti indotti dal PD 128907, potente agonista D3, sulla sequenza di sazietà, nel ratto.

Risultato della ricerca: Articlepeer review

Abstract

The fixed behavioral sequence exhibited by rat in response to food ingestion is called behavioral satietysequence (BSS): cessation of feeding is followed by a period of grooming and activity endings with a period ofresting. This profile of BSS is closely linked to satiety. In different experimental design, BSS has been used toinvestigate whether reduction of food intake, induced by different drugs like D1 and D2 receptor agonist, wasdetermined by an influence on processes underlying satiety or on specific behaviors associated to feeding. Ourrecent data have shown that PD 128907, a D3 receptor agonist, produced a decrease of food intake. In order toassess the mechanism involved in D3 receptors control of feeding, an experiment was performed in which effect ofPD 128907 was analysed on BSS. Male Wistar rats, injected IP with different dosages of PD 128907, were used.Our data show that PD 128907, determined an altered pattern of BSS with significative increases of activity durationand decreases of the resting one. This result suggests that hyperactivity may represent one of the possiblemechanisms of food intake inhibition caused by D3 receptor manipulation.
Lingua originaleItalian
pagine (da-a)49-60
RivistaATTI DELLA ACCADEMIA DI SCIENZE, LETTERE E ARTI DI PALERMO, PARTE PRIMA: SCIENZE
VolumeXXIII
Stato di pubblicazionePublished - 2004

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