Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs

Giuseppe Montalto, Li V. Yang, Melchiorre Cervello, Alberto M. Martelli, Joanna Dulinska-Litewka, Saverio Candido, Ferdinando Nicoletti, Stefano Ratti, Agnieszka Gizak, Kvin Lertpiriyapong, Aurora Scalisi, Dariusz Rakus, Pedro L. Rosalen, Massimo Libra, Linda S. Steelman, Piotr Laidler, James A. Mccubrey, Luca M. Neri, Paolo Lombardi, Ramiro M. MurataLucio Cocco, Giuseppe Montalto, Steve L. Abrams

Risultato della ricerca: Article

47 Citazioni (Scopus)

Abstract

Natural products or nutraceuticals have been shown to elicit anti-aging, anti-cancer and other health-enhancing effects. A key target of the effects of natural products may be the regulation of microRNA (miR) expression which results in cell death or prevents aging, diabetes, cardiovascular and other diseases. This review will focus on a few natural products, especially on resveratrol (RES), curcumin (CUR) and berberine (BBR). RES is obtained from the skins of grapes and other fruits and berries. RES may extend human lifespan by activating the sirtuins and SIRT1 molecules. CUR is isolated from the root of turmeric (Curcuma longa). CUR is currently used in the tutreatment of many disorders, especially in those involving an inflammatory process. CUR and modified derivatives have been shown to have potent anti-cancer effects, especially on cancer stem cells (CSC). BBR is also isolated from various plants (e.g., Coptis chinensis) and has been used for centuries in traditional medicine to treat diseases such as adult- onset diabetes. Understanding the benefits of these and other nutraceuticals may result in approaches to improve human health.
Lingua originaleEnglish
pagine (da-a)1477-1536
Numero di pagine60
RivistaAging
Volume9
Stato di pubblicazionePublished - 2017

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All Science Journal Classification (ASJC) codes

  • Ageing
  • Cell Biology

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Montalto, G., Yang, L. V., Cervello, M., Martelli, A. M., Dulinska-Litewka, J., Candido, S., Nicoletti, F., Ratti, S., Gizak, A., Lertpiriyapong, K., Scalisi, A., Rakus, D., Rosalen, P. L., Libra, M., Steelman, L. S., Laidler, P., Mccubrey, J. A., Neri, L. M., Lombardi, P., ... Abrams, S. L. (2017). Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs. Aging, 9, 1477-1536.