Abstract
Patients with genotype 1 chronic hepatitis C (G1 CHC) frequently develop steatosis and insulin resistance (IR), caused by metabolic and viral factors. These accelerate the progression of liver disease and reduce the response to therapy. A sustained virologic response (SVR) to therapy in patients with G1 CHC is associated strongly with polymorphisms near the interleukin-28B (IL28B) gene, but the interaction between IL28B genotype and IR, and their combined effects on SVR, have not been defined. We tested the association between the IL28B rs12979860 single-nucleotide polymorphism and metabolic features, including IR, and evaluated their effects on SVR.
| Lingua originale | English |
|---|---|
| pagine (da-a) | 311-317.e1 |
| Numero di pagine | 22 |
| Rivista | Clinical Gastroenterology and Hepatology |
| Volume | 11 |
| Stato di pubblicazione | Published - 2013 |
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All Science Journal Classification (ASJC) codes
- Hepatology
- Gastroenterology
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Camma', C., Grimaudo, S., Craxi, A., Caviglia, P., Booth, D., Rizzetto, M., Gambino, R., Rosso, C., Leung, R., Salomone, F., Bugianesi, E., Abate, M. L., Smedile, A., & George, J. (2013). Effects of IL28B rs12979860 CC genotype on metabolic profile and sustained virologic response in patients with genotype 1 chronic hepatitis C. Clinical Gastroenterology and Hepatology, 11, 311-317.e1.