Effects of IL28B rs12979860 CC genotype on metabolic profile and sustained virologic response in patients with genotype 1 chronic hepatitis C

Stefania Grimaudo; Calogero Camma'; Antonio Craxi; Paolo Caviglia; David Booth; Mario Rizzetto; Roberto Gambino; Chiara Rosso; Reynold Leung; Federico Salomone; Elisabetta Bugianesi; Maria Lorena Abate; Antonina Smedile; Jacob George

Effects of IL28B rs12979860 CC genotype on metabolic profile and sustained virologic response in patients with genotype 1 chronic hepatitis C

Stefania Grimaudo, Calogero Camma', Antonio Craxi, Paolo Caviglia, David Booth, Mario Rizzetto, Roberto Gambino, Chiara Rosso, Reynold Leung, Federico Salomone, Elisabetta Bugianesi, Maria Lorena Abate, Antonina Smedile, Jacob George

Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza “G. D’Alessandro”

Risultato della ricerca: Article › peer review

26 Citazioni (Scopus)

Abstract

Patients with genotype 1 chronic hepatitis C (G1 CHC) frequently develop steatosis and insulin resistance (IR), caused by metabolic and viral factors. These accelerate the progression of liver disease and reduce the response to therapy. A sustained virologic response (SVR) to therapy in patients with G1 CHC is associated strongly with polymorphisms near the interleukin-28B (IL28B) gene, but the interaction between IL28B genotype and IR, and their combined effects on SVR, have not been defined. We tested the association between the IL28B rs12979860 single-nucleotide polymorphism and metabolic features, including IR, and evaluated their effects on SVR.

Lingua originale	English
pagine (da-a)	311-317.e1
Numero di pagine	22
Rivista	Clinical Gastroenterology and Hepatology
Volume	11
Stato di pubblicazione	Published - 2013

All Science Journal Classification (ASJC) codes

Hepatology
Gastroenterology

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Grimaudo, S., Camma', C., Craxi, A., Caviglia, P., Booth, D., Rizzetto, M., Gambino, R., Rosso, C., Leung, R., Salomone, F., Bugianesi, E., Abate, M. L., Smedile, A., & George, J. (2013). Effects of IL28B rs12979860 CC genotype on metabolic profile and sustained virologic response in patients with genotype 1 chronic hepatitis C. Clinical Gastroenterology and Hepatology, 11, 311-317.e1.

Effects of IL28B rs12979860 CC genotype on metabolic profile and sustained virologic response in patients with genotype 1 chronic hepatitis C. / Grimaudo, Stefania ; Camma', Calogero ; Craxi, Antonio; Caviglia, Paolo; Booth, David; Rizzetto, Mario; Gambino, Roberto; Rosso, Chiara; Leung, Reynold; Salomone, Federico; Bugianesi, Elisabetta; Abate, Maria Lorena; Smedile, Antonina; George, Jacob.

In: Clinical Gastroenterology and Hepatology, Vol. 11, 2013, pag. 311-317.e1.

Risultato della ricerca: Article › peer review

Grimaudo, S , Camma', C , Craxi, A, Caviglia, P, Booth, D, Rizzetto, M, Gambino, R, Rosso, C, Leung, R, Salomone, F, Bugianesi, E, Abate, ML, Smedile, A & George, J 2013, 'Effects of IL28B rs12979860 CC genotype on metabolic profile and sustained virologic response in patients with genotype 1 chronic hepatitis C', Clinical Gastroenterology and Hepatology, vol. 11, pagg. 311-317.e1.

Grimaudo, Stefania ; Camma', Calogero ; Craxi, Antonio ; Caviglia, Paolo ; Booth, David ; Rizzetto, Mario ; Gambino, Roberto ; Rosso, Chiara ; Leung, Reynold ; Salomone, Federico ; Bugianesi, Elisabetta ; Abate, Maria Lorena ; Smedile, Antonina ; George, Jacob. / Effects of IL28B rs12979860 CC genotype on metabolic profile and sustained virologic response in patients with genotype 1 chronic hepatitis C. In: Clinical Gastroenterology and Hepatology. 2013 ; Vol. 11. pagg. 311-317.e1.

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abstract = "Patients with genotype 1 chronic hepatitis C (G1 CHC) frequently develop steatosis and insulin resistance (IR), caused by metabolic and viral factors. These accelerate the progression of liver disease and reduce the response to therapy. A sustained virologic response (SVR) to therapy in patients with G1 CHC is associated strongly with polymorphisms near the interleukin-28B (IL28B) gene, but the interaction between IL28B genotype and IR, and their combined effects on SVR, have not been defined. We tested the association between the IL28B rs12979860 single-nucleotide polymorphism and metabolic features, including IR, and evaluated their effects on SVR.",

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AU - Grimaudo, Stefania

AU - Camma', Calogero

AU - Craxi, Antonio

AU - Caviglia, Paolo

AU - Booth, David

AU - Rizzetto, Mario

AU - Gambino, Roberto

AU - Rosso, Chiara

AU - Leung, Reynold

AU - Salomone, Federico

AU - Bugianesi, Elisabetta

AU - Abate, Maria Lorena

AU - Smedile, Antonina

AU - George, Jacob

PY - 2013

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N2 - Patients with genotype 1 chronic hepatitis C (G1 CHC) frequently develop steatosis and insulin resistance (IR), caused by metabolic and viral factors. These accelerate the progression of liver disease and reduce the response to therapy. A sustained virologic response (SVR) to therapy in patients with G1 CHC is associated strongly with polymorphisms near the interleukin-28B (IL28B) gene, but the interaction between IL28B genotype and IR, and their combined effects on SVR, have not been defined. We tested the association between the IL28B rs12979860 single-nucleotide polymorphism and metabolic features, including IR, and evaluated their effects on SVR.

AB - Patients with genotype 1 chronic hepatitis C (G1 CHC) frequently develop steatosis and insulin resistance (IR), caused by metabolic and viral factors. These accelerate the progression of liver disease and reduce the response to therapy. A sustained virologic response (SVR) to therapy in patients with G1 CHC is associated strongly with polymorphisms near the interleukin-28B (IL28B) gene, but the interaction between IL28B genotype and IR, and their combined effects on SVR, have not been defined. We tested the association between the IL28B rs12979860 single-nucleotide polymorphism and metabolic features, including IR, and evaluated their effects on SVR.

KW - insulin resistance

KW - interleukin-28B

KW - steatosis

KW - sustained virologic response

KW - insulin resistance

KW - interleukin-28B

KW - steatosis

KW - sustained virologic response

UR - http://hdl.handle.net/10447/73825

M3 - Article

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SP - 311-317.e1

JO - Clinical Gastroenterology and Hepatology

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SN - 1542-3565

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