Effects of hypocaloric diets with different glycemic indexes on endothelialfunction and glycemic variability in overweight and in obese adult patientsat increased cardiovascular risk

Silvio Buscemi, Alessandro Mattina, Giovam Battista Rini, Salvatore Verga, Delia Sprini, Alessandro Mattina, Giuseppe Rosafio, Loretta Cosentino, Manuela Morgana, Giovam Battista Rini, Salvatore Verga, Silvio Buscemi, Giovam Battista Rini

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23 Citazioni (Scopus)

Abstract

Background &amp; aims: The role of glycemic index of the diet in glucose control and cardiovascularprevention is still not clear. The aim of this study was to determine the effects of hypocaloric diets withdifferent glycemic indexes and glycemic loads on endothelial function and glycemic variability innondiabetic participants at increased cardiovascular risk.Methods: Forty nondiabetic obese participants were randomly assigned to a three-month treatment witheither a low glycemic index (LGI; n ¼ 19) or high glycemic index (HGI; n ¼ 21) hypocaloric diet withsimilar macronutrient and fiber content. Endothelial function was measured as flow-mediated dilatation(FMD) of the brachial artery before and after dieting. In addition, 48-h continuous subcutaneous glucosemonitoring was done before and after dieting in a subgroup of 24 participants.Results: The amount of weight loss after dieting was similar in both groups. The glycemic index of the dietsignificantly influenced the FMD (P < 0.005). In particular, the change of FMD was 2.3 2.6% followingthe LGI diet, and 0.9 3.6% after the HGI diet (P < 0.005). The mean 48-h glycemia decreased significantlyafter dietary treatment (P< 0.05), but no significant effect of the glycemic index of the diet onresults was observed. The glycemic index of the diet significantly influenced the 48-h glycemic variabilitymeasured as coefficient of variability (CV%; P< 0.001). The CV% decreased after the LGI diet (from 23.5 to20.0%) and increased after the HGI diet (from 23.6 to 26.6%). The change in percentage of FMD wasinversely correlated with the change in the 48-h glycemic CV% (r¼ 0.45; P < 0.05).Conclusions: Endothelial function and glycemic variability ameliorate in association with the adherenceto an LGI hypocaloric diet in nondiabetic obese persons.Clinical trial registration number: ISRCTN56834511.
Lingua originaleEnglish
Numero di pagine7
RivistaClinical Nutrition
Volume31
Stato di pubblicazionePublished - 2012

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.2700.2706???

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