Effects of high-frequency repetitive transcranial magnetic stimulation of primary motor cortex on laser-evoked potentials in migraine.

Brigida Fierro, Filippo Brighina, Claudia Serpino, Eleonora Vecchio, Vito Devito Francesco, Vittorio Sciruicchio, Marina De Tommaso, Paolo Lamberti, Paolo Livrea, Roberto Santostasi

Risultato della ricerca: Articlepeer review

28 Citazioni (Scopus)

Abstract

The aim of this study was to examine the effects of high-frequency (HF) repetitive transcranial magnetic stimulation (rTMS) of the left primary motor cortex (M1) on subjective pain and evoked responses induced by laser stimulation (LEPs) of the contralateral hand and supraorbital zone in a cohort of migraine patients without aura during the inter-critical phase, and to compare the effects with those of non-migraine healthy controls. Thirteen migraine patients and 12 sex- and age-matched controls were evaluated. Each rTMS session consisted of 1,800 stimuli at a frequency of 5 Hz and 90% motor threshold intensity. Sham (control) rTMS was performed at the same stimulation position. The vertex LEP amplitude was reduced at the trigeminal and hand levels in the sham-placebo condition and after rTMS to a greater extent in the migraine patients than in healthy controls, while the laser pain rating was unaffected. These results suggest that HF rTMS of motor cortex and the sham procedure can both modulate pain-related evoked responses in migraine patients.
Lingua originaleEnglish
pagine (da-a)505-512
Numero di pagine8
RivistaTHE JOURNAL OF HEADACHE AND PAIN
Volume11
Stato di pubblicazionePublished - 2010

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Anesthesiology and Pain Medicine

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