Abstract

There is emerging clinical evidence that amsacrine (m-AMSA) administration may be associated with cardiotoxic effects such as severe, even fatal, ventricular arrhythmias and impairment of the inotropic performance of the heart. Information on the cardiac effects of m-AMSA in animals is scanty. Studies on mice, dogs, and monkeys have not evidenced the cardiotoxicity of the compound. The data presented in this paper show that m-AMSA causes acute ECG alterations in normal rabbits and a dose-related negative inotropic effect on the isolated rabbit heart, suggesting that this species may be a useful model for the study of the cardiac actions of this antiblastic.
Lingua originaleEnglish
pagine (da-a)467-474
Numero di pagine8
RivistaCancer Treatment Reports
Volume67
Stato di pubblicazionePublished - 1983

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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