Abstract
Experimental studies have highlighted that the administration of
3,5-diiodo-L-thyronine (T2) to rats fed diets rich in lipids induces a
decrease of cholesterol and triglycerides plasma levels and body
weight (BW) without inducing liver steatosis. On the basis of these
observations we carried out some experimental in vivo studies to
assess the effects of multiple high doses of T2 on the pituitary thyroid
axis of rats fed diet rich in lipids. Fifteen male Wistar rats were
divided into three groups of five animals each. The first group (N
group) received standard diet, the second group was fed with a high
fat diet (HFD group), while the third group (HFDT2 group) was additionally
given T2 intraperitoneally at a dose level of 70 mg/100 g of BW
three times a week up to four weeks. At the end of the treatment,
blood sample from each animal was collected, centrifuged and the
serum was stored at -20°C. The serum concentrations of thyroidstimulating
hormone (TSH), triiodothyronine, thyroxine, adrenocorticotropic
hormone, triglycerides, cholesterol, glucose, alanineaminotransferase, aspartate aminotransferase, alkaline phosphatase
were then determined. In addition, liver of rats was examined by histology
in order to assess the presence and degree of steatosis. The
administration of T2 to rats fed with a high fat diet suppressed TSH
secretion (P=0.013) while no steatosis was observed in the liver of
these animals. Our data show that multiple administrations of high
doses of T2 to rats fed diets rich in lipid inhibit TSH secretion and
prevent the onset of liver steatosis in these animals.
Lingua originale | English |
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pagine (da-a) | 4-9 |
Numero di pagine | 6 |
Rivista | JOURNAL OF BIOLOGICAL RESEARCH |
Volume | 89 |
Stato di pubblicazione | Published - 2015 |
All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry, medical
- Plant Science